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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 7, 504-512

https://doi.org/10.37358/RC.20.7.8270

Monica Pescaru, Cristina Potre-Oncu, Adina-Ioana Bucur, Bogdan Niculescu, Stela Iurciuc, Virgil Radu Enatescu, Hortensia Ionita, Madalina Veronica Boruga, Ovidiu Potre-Oncu

The Impact of Complex Treatment, Doxorubicin C27H29NO11, Bleomycin C55H84N17O21S3, Vinblastine C46H58N4O9 and Dacarbazine C6H10N6O Correlated with Haematological Parameters on Hodgkin’s Lymphoma Survival Prognostic

Abstract:

Many prognostic factors for HL have been proposed in the past and some of these were included in several prognostic scores. Tumor stage and spread, age, gender and various biological parameters are considered to have an effect on disease evolution, with the prognostic scores stratifying patients into risk groups and guiding the course of treatment. In the present study we have enrolled 54 patients with Hodgkin’s lymphoma admitted in the Hematology Department within the City Emergency Clinical Hospital Timisoara over a 4-year period. We aimed to see if a statistically significant correlation can be made between hemoglobin, white blood cell, lymphocyte, eosinophil, monocyte and platelet levels at the time of diagnosis on the one hand, and response to treatment and patients’ survival, on the other hand. Patients’ response to treatment was evaluated according to Cheson criteria, with best response to the combination of ABVD(doxorubicin C27H29NO11, bleomycin C55H84N17O21S3, vinblastine C46H58N4O9, dacarbazine C6H10N6O) and radiation therapy. Response to treatment was also influenced by eosinophil levels at diagnosis and this has effects on survival. Finally, lymphocyte and platelet levels at diagnosis correlated with survival times in our study group. Therefore, eosinophil, lymphocyte and platelet levels at diagnosis could be considered as prognostic factors for HL, although further studies are needed to validate our findings.
Keywords:
Hodgkin lymphoma; treatment; prognostic factors

Issue: 2020, Volume 71, Issue 7
Pages: 504-512
Publication date: 2020/8/4
https://doi.org/10.37358/RC.20.7.8270
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This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
PESCARU, M., POTRE-ONCU, C., BUCUR, A., NICULESCU, B., IURCIUC, S., ENATESCU, V.R., IONITA, H., BORUGA, M.V., POTRE-ONCU, O., The Impact of Complex Treatment, Doxorubicin C27H29NO11, Bleomycin C55H84N17O21S3, Vinblastine C46H58N4O9 and Dacarbazine C6H10N6O Correlated with Haematological Parameters on Hodgkin’s Lymphoma Survival Prognostic, Rev. Chim., 71(7), 2020, 504-512.

Vancouver
Pescaru M, Potre-Oncu C, Bucur A, Niculescu B, Iurciuc S, Enatescu VR, Ionita H, Boruga MV, Potre-Oncu O. The Impact of Complex Treatment, Doxorubicin C27H29NO11, Bleomycin C55H84N17O21S3, Vinblastine C46H58N4O9 and Dacarbazine C6H10N6O Correlated with Haematological Parameters on Hodgkin’s Lymphoma Survival Prognostic. Rev. Chim.[internet]. 2020 Jul;71(7):504-512. Available from: https://doi.org/10.37358/RC.20.7.8270


APA 6th edition
Pescaru, M., Potre-Oncu, C., Bucur, A., Niculescu, B., Iurciuc, S., Enatescu, V.R.,... Potre-Oncu, O. (2020). The Impact of Complex Treatment, Doxorubicin C27H29NO11, Bleomycin C55H84N17O21S3, Vinblastine C46H58N4O9 and Dacarbazine C6H10N6O Correlated with Haematological Parameters on Hodgkin’s Lymphoma Survival Prognostic. Revista de Chimie, 71(7), 504-512. https://doi.org/10.37358/RC.20.7.8270


Harvard
Pescaru, M., Potre-Oncu, C., Bucur, A., Niculescu, B., Iurciuc, S., Enatescu, V.R., Ionita, H., Boruga, M.V., Potre-Oncu, O. (2020). 'The Impact of Complex Treatment, Doxorubicin C27H29NO11, Bleomycin C55H84N17O21S3, Vinblastine C46H58N4O9 and Dacarbazine C6H10N6O Correlated with Haematological Parameters on Hodgkin’s Lymphoma Survival Prognostic', Revista de Chimie, 71(7), pp. 504-512. https://doi.org/10.37358/RC.20.7.8270


IEEE
M. Pescaru, C. Potre-Oncu, A. Bucur, B. Niculescu, S. Iurciuc, V.R. Enatescu, H. Ionita, M.V. Boruga, O. Potre-Oncu, "The Impact of Complex Treatment, Doxorubicin C27H29NO11, Bleomycin C55H84N17O21S3, Vinblastine C46H58N4O9 and Dacarbazine C6H10N6O Correlated with Haematological Parameters on Hodgkin’s Lymphoma Survival Prognostic". Revista de Chimie, vol. 71, no. 7, pp. 504-512, 2020. [online]. https://doi.org/10.37358/RC.20.7.8270


Text
Monica Pescaru, Cristina Potre-Oncu, Adina-Ioana Bucur, Bogdan Niculescu, Stela Iurciuc, Virgil Radu Enatescu, Hortensia Ionita, Madalina Veronica Boruga, Ovidiu Potre-Oncu,
The Impact of Complex Treatment, Doxorubicin C27H29NO11, Bleomycin C55H84N17O21S3, Vinblastine C46H58N4O9 and Dacarbazine C6H10N6O Correlated with Haematological Parameters on Hodgkin’s Lymphoma Survival Prognostic,
Revista de Chimie,
Volume 71, Issue 7,
2020,
Pages 504-512,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.7.8270.
(https://revistadechimie.ro/Articles.asp?ID=8270)
Keywords: Hodgkin lymphoma; treatment; prognostic factors


RIS
TY - JOUR
T1 - The Impact of Complex Treatment, Doxorubicin C27H29NO11, Bleomycin C55H84N17O21S3, Vinblastine C46H58N4O9 and Dacarbazine C6H10N6O Correlated with Haematological Parameters on Hodgkin’s Lymphoma Survival Prognostic
A1 - Pescaru, Monica
A2 - Potre-Oncu, Cristina
A3 - Bucur, Adina-Ioana
A4 - Niculescu, Bogdan
A5 - Iurciuc, Stela
A6 - Enatescu, Virgil Radu
A7 - Ionita, Hortensia
A8 - Boruga, Madalina Veronica
A9 - Potre-Oncu, Ovidiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 7
SP - 504
EP - 512
UR - https://doi.org/10.37358/RC.20.7.8270
KW - Hodgkin lymphoma
KW - treatment
KW - prognostic factors
ER -


BibTex
@article{RevCh2020P504,
author = {Pescaru Monica and Potre-Oncu Cristina and Bucur Adina-Ioana and Niculescu Bogdan and Iurciuc Stela and Enatescu Virgil Radu and Ionita Hortensia and Boruga Madalina Veronica and Potre-Oncu Ovidiu},
title = {The Impact of Complex Treatment, Doxorubicin C27H29NO11, Bleomycin C55H84N17O21S3, Vinblastine C46H58N4O9 and Dacarbazine C6H10N6O Correlated with Haematological Parameters on Hodgkin’s Lymphoma Survival Prognostic},
journal = {Revista de Chimie},
volume = {71},
number = {7},
pages = {504-512},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.7.8270},
url = {https://revistadechimie.ro/Articles.asp?ID=8270}
}
 
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