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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 7, 444-454

https://doi.org/10.37358/RC.20.7.8262

Dragos Serban, Cristian Mihai Branescu, Daniel Alin Cristian, Ana Maria Dascalu

Bilirubin, Interleukin 6 (IL 6) and Lipopolysaccharide -Binding Protein (LBP) - Biomarkers of Sepsis in Appendicular Peritonitis

Abstract:

Peritonitis remains, despite the diagnostic and therapeutic developments, a serious condition, the main cause of septic shock with lethal potential in abdominal surgery Identifying and characterizing the dynamics of early biomarkers of the inflammatory response in abdominal sepsis is important to better follow-up evolution and postoperative infectious complications. The paper aims to study the dynamics of serum concentration of biomarkers LBP, IL6 and bilirubin in patients with acute peritonitis of appendicular cause, in the pre and postoperative stage and the correlation with the clinical evolution of inflammatory syndrome. A prospective 6-month study was performed, including patients for appendicular peritonitis. LBP, IL6, bilirubin, leukocytes were sampled preoperatively, then postoperatively at 72 h, and repeated at 72 h until values returned to normal. Clinical evolution and leukocytes were correlated with biochemical parameters. The mean preoperative values for the studied biochemical parameters were for Il6 of 14.81 +/- 4,047 pg / mL, for LBP of 33,826 +/- 5.5.02 microgram / mL and for bilirubin of 1.77 +/- 0.55mg / mL. The postoperative values decreased in all cases, but remained above normal limits in cases with septic complications. LBP, Il 6 and bilirubin are biomarkers useful in the pre- and postoperative evaluation of sepsis in appendicular peritonitis, correlating more accurately with the evolution of the inflammatory response than leukocytosis. Bilirubin is useful in monitoring intraperitoneal infection, but is not influenced by the existence of extraperitoneal infection. The dynamics of LBP is the most accurate description of bacterial infectious factor exposure.
Keywords:
Lipopolysaccharide - Binding Protein (LBP); Interleukin 6 (Il 6); Bilirubin; biomarker; peritonitis

Issue: 2020, Volume 71, Issue 7
Pages: 444-454
Publication date: 2020/8/4
https://doi.org/10.37358/RC.20.7.8262
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
SERBAN, D., BRANESCU, C.M., CRISTIAN, D.A., DASCALU, A.M., Bilirubin, Interleukin 6 (IL 6) and Lipopolysaccharide -Binding Protein (LBP) - Biomarkers of Sepsis in Appendicular Peritonitis, Rev. Chim., 71(7), 2020, 444-454.

Vancouver
Serban D, Branescu CM, Cristian DA, Dascalu AM. Bilirubin, Interleukin 6 (IL 6) and Lipopolysaccharide -Binding Protein (LBP) - Biomarkers of Sepsis in Appendicular Peritonitis. Rev. Chim.[internet]. 2020 Jul;71(7):444-454. Available from: https://doi.org/10.37358/RC.20.7.8262


APA 6th edition
Serban, D., Branescu, C.M., Cristian, D.A. & Dascalu, A.M. (2020). Bilirubin, Interleukin 6 (IL 6) and Lipopolysaccharide -Binding Protein (LBP) - Biomarkers of Sepsis in Appendicular Peritonitis. Revista de Chimie, 71(7), 444-454. https://doi.org/10.37358/RC.20.7.8262


Harvard
Serban, D., Branescu, C.M., Cristian, D.A., Dascalu, A.M. (2020). 'Bilirubin, Interleukin 6 (IL 6) and Lipopolysaccharide -Binding Protein (LBP) - Biomarkers of Sepsis in Appendicular Peritonitis', Revista de Chimie, 71(7), pp. 444-454. https://doi.org/10.37358/RC.20.7.8262


IEEE
D. Serban, C.M. Branescu, D.A. Cristian, A.M. Dascalu, "Bilirubin, Interleukin 6 (IL 6) and Lipopolysaccharide -Binding Protein (LBP) - Biomarkers of Sepsis in Appendicular Peritonitis". Revista de Chimie, vol. 71, no. 7, pp. 444-454, 2020. [online]. https://doi.org/10.37358/RC.20.7.8262


Text
Dragos Serban, Cristian Mihai Branescu, Daniel Alin Cristian, Ana Maria Dascalu,
Bilirubin, Interleukin 6 (IL 6) and Lipopolysaccharide -Binding Protein (LBP) - Biomarkers of Sepsis in Appendicular Peritonitis,
Revista de Chimie,
Volume 71, Issue 7,
2020,
Pages 444-454,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.7.8262.
(https://revistadechimie.ro/Articles.asp?ID=8262)
Keywords: Lipopolysaccharide - Binding Protein (LBP); Interleukin 6 (Il 6); Bilirubin; biomarker; peritonitis


RIS
TY - JOUR
T1 - Bilirubin, Interleukin 6 (IL 6) and Lipopolysaccharide -Binding Protein (LBP) - Biomarkers of Sepsis in Appendicular Peritonitis
A1 - Serban, Dragos
A2 - Branescu, Cristian Mihai
A3 - Cristian, Daniel Alin
A4 - Dascalu, Ana Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 7
SP - 444
EP - 454
UR - https://doi.org/10.37358/RC.20.7.8262
KW - Lipopolysaccharide - Binding Protein (LBP)
KW - Interleukin 6 (Il 6)
KW - Bilirubin
KW - biomarker
KW - peritonitis
ER -


BibTex
@article{RevCh2020P444,
author = {Serban Dragos and Branescu Cristian Mihai and Cristian Daniel Alin and Dascalu Ana Maria},
title = {Bilirubin, Interleukin 6 (IL 6) and Lipopolysaccharide -Binding Protein (LBP) - Biomarkers of Sepsis in Appendicular Peritonitis},
journal = {Revista de Chimie},
volume = {71},
number = {7},
pages = {444-454},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.7.8262},
url = {https://revistadechimie.ro/Articles.asp?ID=8262}
}
 
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