Immunohistochemistry and Biochemistry Features of Interstitial Mesenchymal Cells in Ischemic Cardiac Diseases

Ceausu, Zenaida; Socea, Bogdan; Dimitriu, Mihai; Gheorghiu, Diana; Pacu, Irina; Bacalbasa, Nicolae; Serban, Dragos; Costache, Mariana; Ceausu, Mihai

Zenaida Ceausu, Bogdan Socea, Mihai Dimitriu, Diana Gheorghiu, Irina Pacu, Nicolae Bacalbasa, Dragos Serban, Mariana Costache, Mihai Ceausu

Immunohistochemistry and Biochemistry Features of Interstitial Mesenchymal Cells in Ischemic Cardiac Diseases

Abstract:

In the cardiac remodelling game, the casting is represented by certain players in form of four mesenchymal cells: one main player, represented by the fibroblast /and three secondary players, represented by the endothelial cell, vascular smooth muscle cell and the cardiac stem cell. The fibroblast plays a role in recruiting inflammatory cells (PMN, macrophages) in the primary secretory phase and another role in extracellular matrix remodelling in the secondary proliferative phase. Myofibroblasts are mesenchymal cells that, due to their phenotype, are often described as a bridge between fibroblasts and smooth muscle. The endothelial cells and vascular smooth muscle cells are involved in vascular remodelling, while the cardiac stem cells are involved in cardiogenesis, but at a slow rate. Last, but not least, there are transient players, in the very first moments of the game, represented by the inflammatory cells (PMN, macrophages), which clean the injured (necrobiotic) area, paving the way for the myofibroblast to cardiac remodelling. Ischemic lesions, as well as cardiac tumours produce a large variety of symptoms and changes in extracellular matrix composition.

Keywords:
extracellular matrix; mesenchymal cells; fibroblast; cardiac disease

Issue: 2020, Volume 71, Issue 7

Pages: 436-443

Publication date: 2020/8/4

https://doi.org/10.37358/RC.20.7.8261

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CEAUSU, Z., SOCEA, B., DIMITRIU, M., GHEORGHIU, D., PACU, I., BACALBASA, N., SERBAN, D., COSTACHE, M., CEAUSU, M., Immunohistochemistry and Biochemistry Features of Interstitial Mesenchymal Cells in Ischemic Cardiac Diseases, Rev. Chim., 71(7), 2020, 436-443.

Vancouver
Ceausu Z, Socea B, Dimitriu M, Gheorghiu D, Pacu I, Bacalbasa N, Serban D, Costache M, Ceausu M. Immunohistochemistry and Biochemistry Features of Interstitial Mesenchymal Cells in Ischemic Cardiac Diseases. Rev. Chim.[internet]. 2020 Jul;71(7):436-443. Available from: https://doi.org/10.37358/RC.20.7.8261

APA 6th edition
Ceausu, Z., Socea, B., Dimitriu, M., Gheorghiu, D., Pacu, I., Bacalbasa, N.,... Ceausu, M. (2020). Immunohistochemistry and Biochemistry Features of Interstitial Mesenchymal Cells in Ischemic Cardiac Diseases. Revista de Chimie, 71(7), 436-443. https://doi.org/10.37358/RC.20.7.8261

Harvard
Ceausu, Z., Socea, B., Dimitriu, M., Gheorghiu, D., Pacu, I., Bacalbasa, N., Serban, D., Costache, M., Ceausu, M. (2020). 'Immunohistochemistry and Biochemistry Features of Interstitial Mesenchymal Cells in Ischemic Cardiac Diseases', Revista de Chimie, 71(7), pp. 436-443. https://doi.org/10.37358/RC.20.7.8261

IEEE
Z. Ceausu, B. Socea, M. Dimitriu, D. Gheorghiu, I. Pacu, N. Bacalbasa, D. Serban, M. Costache, M. Ceausu, "Immunohistochemistry and Biochemistry Features of Interstitial Mesenchymal Cells in Ischemic Cardiac Diseases". Revista de Chimie, vol. 71, no. 7, pp. 436-443, 2020. [online]. https://doi.org/10.37358/RC.20.7.8261

Text
Zenaida Ceausu, Bogdan Socea, Mihai Dimitriu, Diana Gheorghiu, Irina Pacu, Nicolae Bacalbasa, Dragos Serban, Mariana Costache, Mihai Ceausu,
Immunohistochemistry and Biochemistry Features of Interstitial Mesenchymal Cells in Ischemic Cardiac Diseases,
Revista de Chimie,
Volume 71, Issue 7,
2020,
Pages 436-443,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.7.8261.
(https://revistadechimie.ro/Articles.asp?ID=8261)
Keywords: extracellular matrix; mesenchymal cells; fibroblast; cardiac disease

RIS
TY - JOUR
T1 - Immunohistochemistry and Biochemistry Features of Interstitial Mesenchymal Cells in Ischemic Cardiac Diseases
A1 - Ceausu, Zenaida
A2 - Socea, Bogdan
A3 - Dimitriu, Mihai
A4 - Gheorghiu, Diana
A5 - Pacu, Irina
A6 - Bacalbasa, Nicolae
A7 - Serban, Dragos
A8 - Costache, Mariana
A9 - Ceausu, Mihai
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 7
SP - 436
EP - 443
UR - https://doi.org/10.37358/RC.20.7.8261
KW - extracellular matrix
KW - mesenchymal cells
KW - fibroblast
KW - cardiac disease
ER -

BibTex
@article{RevCh2020P436,
author = {Ceausu Zenaida and Socea Bogdan and Dimitriu Mihai and Gheorghiu Diana and Pacu Irina and Bacalbasa Nicolae and Serban Dragos and Costache Mariana and Ceausu Mihai},
title = {Immunohistochemistry and Biochemistry Features of Interstitial Mesenchymal Cells in Ischemic Cardiac Diseases},
journal = {Revista de Chimie},
volume = {71},
number = {7},
pages = {436-443},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.7.8261},
url = {https://revistadechimie.ro/Articles.asp?ID=8261}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)