The Corelation Between Serum Estradiol (C23H32O3) Impact on Selected Biomarkers and Outcome of Fresh Embryo Transfer in Comparison with Freeze All Strategy in in vitro Fertilisation Patients

Albu, Dragos; Albu, Alice; Sima, Romina Marina; Poenaru, Mircea Octavian; Neacsu, Adrian; Toader, Oana; Chicea, Radu; Ples, Liana

Dragos Albu, Alice Albu, Romina Marina Sima, Mircea Octavian Poenaru, Adrian Neacsu, Oana Toader, Radu Chicea, Liana Ples

The Corelation Between Serum Estradiol (C23H32O3) Impact on Selected Biomarkers and Outcome of Fresh Embryo Transfer in Comparison with Freeze All Strategy in in vitro Fertilisation Patients

Abstract:

In stimulated cycles the endometrium could be more advanced than the embryos, with a possible negative impact on their implantation capacity. Therefore, there is an ongoing debate regarding the best transfer strategy: freeze-all versus fresh embryos transfer. Our study aimed to analyse if the frozen only embryos-transfer strategy for in vitro fertilisation (IVF) has higher clinical pregnancy rate (CPR) than the traditionally fresh transfer. We performed a retrospective study in a private centre of reproductive medicine. We included only patients who performed fresh embryo transfers (n=245) and patients with all the embryos frozen and then transferred into a non-stimulated cycle (n=117). The reasons for delayed transfer were an increased risk of ovarian hyperstimulation syndrome or the increase of late follicular phase serum progesterone level. The mean age of the study group was 34.33+-b4.28 years and mean AMH was 3.68+-b3.56 ng/mL. Patients with fresh transfer were significantly older (p[0.0001) and obtained significantly lower number of oocytes at egg retrieval (p[0.0001) and lower zygotes number (p[0.0001) in comparison with patients with frozen transfer. After adjustment for confounders, CPR was significantly higher in patients with fresh transfer in comparison with those with frozen transfer in total group (OR 2.7, p=0.001) and in patients with cleavage stage embryo transfer (OR 6, p=0.008), but not in patients with blastocyst transfer. Similarly, the implantation rate was significantly higher in total group and in both subgroups (p[0.0001). Our study shows that the freeze all strategy should not be performed in all the patients, being inferior to fresh transfer in the total study group and cleavage stage embryo transfers. The decision to transfer frozen embryos should take into account the availability of blastocysts for transfer and the risk benefit profile.

Keywords:
CRYOTOP; IVF; implantation rate; fresh embryo transfer; clinical pregnancy rate

Issue: 2020, Volume 71, Issue 7

Pages: 419-424

Publication date: 2020/8/4

https://doi.org/10.37358/RC.20.7.8259

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ALBU, D., ALBU, A., SIMA, R.M., POENARU, M.O., NEACSU, A., TOADER, O., CHICEA, R., PLES, L., The Corelation Between Serum Estradiol (C23H32O3) Impact on Selected Biomarkers and Outcome of Fresh Embryo Transfer in Comparison with Freeze All Strategy in in vitro Fertilisation Patients, Rev. Chim., 71(7), 2020, 419-424.

Vancouver
Albu D, Albu A, Sima RM, Poenaru MO, Neacsu A, Toader O, Chicea R, Ples L. The Corelation Between Serum Estradiol (C23H32O3) Impact on Selected Biomarkers and Outcome of Fresh Embryo Transfer in Comparison with Freeze All Strategy in in vitro Fertilisation Patients. Rev. Chim.[internet]. 2020 Jul;71(7):419-424. Available from: https://doi.org/10.37358/RC.20.7.8259

APA 6th edition
Albu, D., Albu, A., Sima, R.M., Poenaru, M.O., Neacsu, A., Toader, O., Chicea, R. & Ples, L. (2020). The Corelation Between Serum Estradiol (C23H32O3) Impact on Selected Biomarkers and Outcome of Fresh Embryo Transfer in Comparison with Freeze All Strategy in in vitro Fertilisation Patients. Revista de Chimie, 71(7), 419-424. https://doi.org/10.37358/RC.20.7.8259

Harvard
Albu, D., Albu, A., Sima, R.M., Poenaru, M.O., Neacsu, A., Toader, O., Chicea, R., Ples, L. (2020). 'The Corelation Between Serum Estradiol (C23H32O3) Impact on Selected Biomarkers and Outcome of Fresh Embryo Transfer in Comparison with Freeze All Strategy in in vitro Fertilisation Patients', Revista de Chimie, 71(7), pp. 419-424. https://doi.org/10.37358/RC.20.7.8259

IEEE
D. Albu, A. Albu, R.M. Sima, M.O. Poenaru, A. Neacsu, O. Toader, R. Chicea, L. Ples, "The Corelation Between Serum Estradiol (C23H32O3) Impact on Selected Biomarkers and Outcome of Fresh Embryo Transfer in Comparison with Freeze All Strategy in in vitro Fertilisation Patients". Revista de Chimie, vol. 71, no. 7, pp. 419-424, 2020. [online]. https://doi.org/10.37358/RC.20.7.8259

Text
Dragos Albu, Alice Albu, Romina Marina Sima, Mircea Octavian Poenaru, Adrian Neacsu, Oana Toader, Radu Chicea, Liana Ples,
The Corelation Between Serum Estradiol (C23H32O3) Impact on Selected Biomarkers and Outcome of Fresh Embryo Transfer in Comparison with Freeze All Strategy in in vitro Fertilisation Patients,
Revista de Chimie,
Volume 71, Issue 7,
2020,
Pages 419-424,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.7.8259.
(https://revistadechimie.ro/Articles.asp?ID=8259)
Keywords: CRYOTOP; IVF; implantation rate; fresh embryo transfer; clinical pregnancy rate

RIS
TY - JOUR
T1 - The Corelation Between Serum Estradiol (C23H32O3) Impact on Selected Biomarkers and Outcome of Fresh Embryo Transfer in Comparison with Freeze All Strategy in in vitro Fertilisation Patients
A1 - Albu, Dragos
A2 - Albu, Alice
A3 - Sima, Romina Marina
A4 - Poenaru, Mircea Octavian
A5 - Neacsu, Adrian
A6 - Toader, Oana
A7 - Chicea, Radu
A8 - Ples, Liana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 7
SP - 419
EP - 424
UR - https://doi.org/10.37358/RC.20.7.8259
KW - CRYOTOP
KW - IVF; implantation rate; fresh embryo transfer
KW - clinical pregnancy rate
ER -

BibTex
@article{RevCh2020P419,
author = {Albu Dragos and Albu Alice and Sima Romina Marina and Poenaru Mircea Octavian and Neacsu Adrian and Toader Oana and Chicea Radu and Ples Liana},
title = {The Corelation Between Serum Estradiol (C23H32O3) Impact on Selected Biomarkers and Outcome of Fresh Embryo Transfer in Comparison with Freeze All Strategy in in vitro Fertilisation Patients},
journal = {Revista de Chimie},
volume = {71},
number = {7},
pages = {419-424},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.7.8259},
url = {https://revistadechimie.ro/Articles.asp?ID=8259}
}

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