Matrix Gla Protein in Meningiomas: An Immunohistochemical Study

Gheorghe, Simona Roxana; Tataranu, Ligia Gabriela; Dricu, Anica; Silaghi, Ciprian Nicolae; Vermeer, Cees; Craciun, Alexandra Marioara

Simona Roxana Gheorghe, Ligia Gabriela Tataranu, Anica Dricu, Ciprian Nicolae Silaghi, Cees Vermeer, Alexandra Marioara Craciun

Matrix Gla Protein in Meningiomas: An Immunohistochemical Study

Abstract:

Calcified meningiomas have a slower growth rate and a better outcome than non-calcified meningiomas. Matrix Gla Protein (MGP) acts as an inhibitor of soft tissue calcification. Depending on its carboxylation status MGP may occur in two conformations: uncarboxylated (ucMGP) or carboxylated (cMGP). Low levels of serum ucMGP have been described to be a sign of tissue calcification. In calcified tumoral tissue samples we identified both ucMGP (r = 0.957, p[0.001) and cMGP (r = 1, p[0.001), while non-calcified tumors were negative for both MGP conformation deposits. The concentration of serum t-ucMGP in patients with calcified and non-calcified meningiomas were not significantly different (3499±1388 vs. 3882±2558).

Keywords:
calcification; uncarboxylated matrix gla protein; carboxylated matrix gla protein; immunohistochemistry

Issue: 2020, Volume 71, Issue 3

Pages: 425-432

Publication date: 2020/4/3

https://doi.org/10.37358/RC.20.3.8016

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GHEORGHE, S.R., TATARANU, L.G., DRICU, A., SILAGHI, C.N., VERMEER, C., CRACIUN, A.M., Matrix Gla Protein in Meningiomas: An Immunohistochemical Study, Rev. Chim., 71(3), 2020, 425-432.

Vancouver
Gheorghe SR, Tataranu LG, Dricu A, Silaghi CN, Vermeer C, Craciun AM. Matrix Gla Protein in Meningiomas: An Immunohistochemical Study. Rev. Chim.[internet]. 2020 Mar;71(3):425-432. Available from: https://doi.org/10.37358/RC.20.3.8016

APA 6th edition
Gheorghe, S.R., Tataranu, L.G., Dricu, A., Silaghi, C.N., Vermeer, C. & Craciun, A.M. (2020). Matrix Gla Protein in Meningiomas: An Immunohistochemical Study. Revista de Chimie, 71(3), 425-432. https://doi.org/10.37358/RC.20.3.8016

Harvard
Gheorghe, S.R., Tataranu, L.G., Dricu, A., Silaghi, C.N., Vermeer, C., Craciun, A.M. (2020). 'Matrix Gla Protein in Meningiomas: An Immunohistochemical Study', Revista de Chimie, 71(3), pp. 425-432. https://doi.org/10.37358/RC.20.3.8016

IEEE
S.R. Gheorghe, L.G. Tataranu, A. Dricu, C.N. Silaghi, C. Vermeer, A.M. Craciun, "Matrix Gla Protein in Meningiomas: An Immunohistochemical Study". Revista de Chimie, vol. 71, no. 3, pp. 425-432, 2020. [online]. https://doi.org/10.37358/RC.20.3.8016

Text
Simona Roxana Gheorghe, Ligia Gabriela Tataranu, Anica Dricu, Ciprian Nicolae Silaghi, Cees Vermeer, Alexandra Marioara Craciun,
Matrix Gla Protein in Meningiomas: An Immunohistochemical Study,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 425-432,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.8016.
(https://revistadechimie.ro/Articles.asp?ID=8016)
Keywords: calcification; uncarboxylated matrix gla protein; carboxylated matrix gla protein; immunohistochemistry

RIS
TY - JOUR
T1 - Matrix Gla Protein in Meningiomas: An Immunohistochemical Study
A1 - Gheorghe, Simona Roxana
A2 - Tataranu, Ligia Gabriela
A3 - Dricu, Anica
A4 - Silaghi, Ciprian Nicolae
A5 - Vermeer, Cees
A6 - Craciun, Alexandra Marioara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 425
EP - 432
UR - https://doi.org/10.37358/RC.20.3.8016
KW - calcification
KW - uncarboxylated matrix gla protein
KW - carboxylated matrix gla protein
KW - immunohistochemistry
ER -

BibTex
@article{RevCh2020P425,
author = {Gheorghe Simona Roxana and Tataranu Ligia Gabriela and Dricu Anica and Silaghi Ciprian Nicolae and Vermeer Cees and Craciun Alexandra Marioara},
title = {Matrix Gla Protein in Meningiomas: An Immunohistochemical Study},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {425-432},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.8016},
url = {https://revistadechimie.ro/Articles.asp?ID=8016}
}

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