Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment

Eva, Lucian; Duceac, Letitia Doina; Stafie, Liviu; Marcu, Constantin; Mitrea, Geta; Goroftei, Elena Roxana Bogdan; Hanganu, Elena; Ciomaga, Irina Mihaela; Iordache, Alin Constantin; Luca, Alina Costina; Anton-Paduraru, Dana-Teodora; Ciuhodaru, Madalina Irina

Lucian Eva, Letitia Doina Duceac, Liviu Stafie, Constantin Marcu, Geta Mitrea, Elena Roxana Bogdan Goroftei, Elena Hanganu, Irina Mihaela Ciomaga, Alin Constantin Iordache, Alina Costina Luca, Dana-Teodora Anton-Paduraru, Madalina Irina Ciuhodaru

Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment

Abstract:

The fourth generation cephalosporin antibacterial agent, cefepime, was loaded into layered double hydroxides for enhancing antibiotic efficiency, reducing side effects, as well as achieving the sustained release property. The intercalation of antibiotic into the inter-gallery of ZnAl-layered double hydroxide (LDH) was carried out using ion exchange method, by this constituting a nano-sized organic-inorganic hybrid material for a controlled release novel formulation. Although cefepime is a broad spectrum antibiotic, it has various adverse effects and a significant degradation rate. Thus, the preparation and physico-chemical characterization of nanomaterials able to intercalate this drug is an important study for medical and pharmaceutical field. The antibiotic inclusion into LDHs nanostructure was confirmed by advanced characterization techniques and the release profile of cefepime was analysed with the respect to pH of the simulated media.

Keywords:
nanomaterials; cephalosporin; epidemiology; neurosurgery; paediatrics surgery/pediatric disorders; pulmonology; obstetrics/gynaecology. drug release

Issue: 2020, Volume 71, Issue 3

Pages: 342-349

Publication date: 2020/4/3

https://doi.org/10.37358/RC.20.3.8007

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
EVA, L., DUCEAC, L.D., STAFIE, L., MARCU, C., MITREA, G., GOROFTEI, E.R.B., HANGANU, E., CIOMAGA, I.M., IORDACHE, A.C., LUCA, A.C., ANTON-PADURARU, D., CIUHODARU, M.I., Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment, Rev. Chim., 71(3), 2020, 342-349.

Vancouver
Eva L, Duceac LD, Stafie L, Marcu C, Mitrea G, Goroftei ERB, Hanganu E, Ciomaga IM, Iordache AC, Luca AC, Anton-Paduraru D, Ciuhodaru MI. Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment. Rev. Chim.[internet]. 2020 Mar;71(3):342-349. Available from: https://doi.org/10.37358/RC.20.3.8007

APA 6th edition
Eva, L., Duceac, L.D., Stafie, L., Marcu, C., Mitrea, G., Goroftei, E.R.B.,... Ciuhodaru, M.I. (2020). Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment. Revista de Chimie, 71(3), 342-349. https://doi.org/10.37358/RC.20.3.8007

Harvard
Eva, L., Duceac, L.D., Stafie, L., Marcu, C., Mitrea, G., Goroftei, E.R.B., Hanganu, E., Ciomaga, I.M., Iordache, A.C., Luca, A.C., Anton-Paduraru, D., Ciuhodaru, M.I. (2020). 'Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment', Revista de Chimie, 71(3), pp. 342-349. https://doi.org/10.37358/RC.20.3.8007

IEEE
L. Eva, L.D. Duceac, L. Stafie, C. Marcu, G. Mitrea, E.R.B. Goroftei, E. Hanganu, I.M. Ciomaga, A.C. Iordache, A.C. Luca, D. Anton-Paduraru, M.I. Ciuhodaru, "Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment". Revista de Chimie, vol. 71, no. 3, pp. 342-349, 2020. [online]. https://doi.org/10.37358/RC.20.3.8007

Text
Lucian Eva, Letitia Doina Duceac, Liviu Stafie, Constantin Marcu, Geta Mitrea, Elena Roxana Bogdan Goroftei, Elena Hanganu, Irina Mihaela Ciomaga, Alin Constantin Iordache, Alina Costina Luca, Dana-Teodora Anton-Paduraru, Madalina Irina Ciuhodaru,
Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 342-349,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.8007.
(https://revistadechimie.ro/Articles.asp?ID=8007)
Keywords: nanomaterials; cephalosporin; epidemiology; neurosurgery; paediatrics surgery/pediatric disorders; pulmonology; obstetrics/gynaecology. drug release

RIS
TY - JOUR
T1 - Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment
A1 - Eva, Lucian
A2 - Duceac, Letitia Doina
A3 - Stafie, Liviu
A4 - Marcu, Constantin
A5 - Mitrea, Geta
A6 - Goroftei, Elena Roxana Bogdan
A7 - Hanganu, Elena
A8 - Ciomaga, Irina Mihaela
A9 - Iordache, Alin Constantin
A10 - Luca, Alina Costina
A11 - Anton-Paduraru, Dana-Teodora
A12 - Ciuhodaru, Madalina Irina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 342
EP - 349
UR - https://doi.org/10.37358/RC.20.3.8007
KW - nanomaterials
KW - cephalosporin
KW - epidemiology
KW - neurosurgery
KW - paediatrics surgery/pediatric disorders
KW - pulmonology
KW - obstetrics/gynaecology. drug release
ER -

BibTex
@article{RevCh2020P342,
author = {Eva Lucian and Duceac Letitia Doina and Stafie Liviu and Marcu Constantin and Mitrea Geta and Goroftei Elena Roxana Bogdan and Hanganu Elena and Ciomaga Irina Mihaela and Iordache Alin Constantin and Luca Alina Costina and Anton-Paduraru Dana-Teodora and Ciuhodaru Madalina Irina},
title = {Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {342-349},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.8007},
url = {https://revistadechimie.ro/Articles.asp?ID=8007}
}

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