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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 3, 335-341

https://doi.org/10.37358/RC.20.3.8006

Paul Tutac, Noemi Meszaros, Nicoleta Andreescu, Simona Farcas, Andreea Iulia Dobrescu, Daniela Amzar, Maria Puiu

Vascular Endothelial Growth Factor Gene Polymorphisms in Women who Experienced Repeated Pregnancy Losses

Abstract:

The well accepted causes of pregnancy loss are chromosomal anomalies, uterine anomalies, thrombophilic and immune disorders and endocrine dysfunction. During early gestation, VEGF is essential for the maturation of oocytes, the proliferation of trophoblasts, the implantation and development of the embryo, the angiogenesis of the placenta, and the growth of maternal and fetal blood vessels in the uterus. The aim of this study is to establish the incidence of -634G/C VEGF polymorphism in our study lot that included women with recurrent miscarriages as well a comparation with the incidence of the same polymorphism in a control lot of subjects with no reproduction faillure history. The study lot included 35 women with multiple pregnancies losses, aged between 18 and 41 years old. The control lot consists of 59 healthy individuals that had no experience of reproductive failure. Genotyping of -634G/C VEGF was done for both study and control lots. We found a significant statistic difference of the alleles frequencies between the two tested cohorts, the study lot and the control lot. Further studies should focus on testing VEGF variants in women that experience repeated pregnancy losses in order to establish an association among VEGF polymorphisms, endometrial VEGF expression and plasma VEGF levels in RPL patients.
Keywords:
VEGF; pregnancy loss; regulator; rs2010963; Real-Time PCR; protein

Issue: 2020, Volume 71, Issue 3
Pages: 335-341
Publication date: 2020/4/3
https://doi.org/10.37358/RC.20.3.8006
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
TUTAC, P., MESZAROS, N., ANDREESCU, N., FARCAS, S., DOBRESCU, A.I., AMZAR, D., PUIU, M., Vascular Endothelial Growth Factor Gene Polymorphisms in Women who Experienced Repeated Pregnancy Losses, Rev. Chim., 71(3), 2020, 335-341.

Vancouver
Tutac P, Meszaros N, Andreescu N, Farcas S, Dobrescu AI, Amzar D, Puiu M. Vascular Endothelial Growth Factor Gene Polymorphisms in Women who Experienced Repeated Pregnancy Losses. Rev. Chim.[internet]. 2020 Mar;71(3):335-341. Available from: https://doi.org/10.37358/RC.20.3.8006


APA 6th edition
Tutac, P., Meszaros, N., Andreescu, N., Farcas, S., Dobrescu, A.I., Amzar, D. & Puiu, M. (2020). Vascular Endothelial Growth Factor Gene Polymorphisms in Women who Experienced Repeated Pregnancy Losses. Revista de Chimie, 71(3), 335-341. https://doi.org/10.37358/RC.20.3.8006


Harvard
Tutac, P., Meszaros, N., Andreescu, N., Farcas, S., Dobrescu, A.I., Amzar, D., Puiu, M. (2020). 'Vascular Endothelial Growth Factor Gene Polymorphisms in Women who Experienced Repeated Pregnancy Losses', Revista de Chimie, 71(3), pp. 335-341. https://doi.org/10.37358/RC.20.3.8006


IEEE
P. Tutac, N. Meszaros, N. Andreescu, S. Farcas, A.I. Dobrescu, D. Amzar, M. Puiu, "Vascular Endothelial Growth Factor Gene Polymorphisms in Women who Experienced Repeated Pregnancy Losses". Revista de Chimie, vol. 71, no. 3, pp. 335-341, 2020. [online]. https://doi.org/10.37358/RC.20.3.8006


Text
Paul Tutac, Noemi Meszaros, Nicoleta Andreescu, Simona Farcas, Andreea Iulia Dobrescu, Daniela Amzar, Maria Puiu,
Vascular Endothelial Growth Factor Gene Polymorphisms in Women who Experienced Repeated Pregnancy Losses,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 335-341,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.8006.
(https://revistadechimie.ro/Articles.asp?ID=8006)
Keywords: VEGF; pregnancy loss; regulator; rs2010963; Real-Time PCR; protein


RIS
TY - JOUR
T1 - Vascular Endothelial Growth Factor Gene Polymorphisms in Women who Experienced Repeated Pregnancy Losses
A1 - Tutac, Paul
A2 - Meszaros, Noemi
A3 - Andreescu, Nicoleta
A4 - Farcas, Simona
A5 - Dobrescu, Andreea Iulia
A6 - Amzar, Daniela
A7 - Puiu, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 335
EP - 341
UR - https://doi.org/10.37358/RC.20.3.8006
KW - VEGF
KW - pregnancy loss
KW - regulator
KW - rs2010963
KW - Real-Time PCR
KW - protein
ER -


BibTex
@article{RevCh2020P335,
author = {Tutac Paul and Meszaros Noemi and Andreescu Nicoleta and Farcas Simona and Dobrescu Andreea Iulia and Amzar Daniela and Puiu Maria},
title = {Vascular Endothelial Growth Factor Gene Polymorphisms in Women who Experienced Repeated Pregnancy Losses},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {335-341},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.8006},
url = {https://revistadechimie.ro/Articles.asp?ID=8006}
}
 
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