Clinical Biochemistry of Cushing Syndrome in Dogs

Boghian, Vasile

Vasile Boghian

Clinical Biochemistry of Cushing Syndrome in Dogs

Abstract:

The aim of the study is to determine clinical and paraclinical elements useful in the diagnosis of hyperadrenocorticism, given that the symptoms are varied and often similar to dermatitis or liver disease. Clinical signs in dogs with hyperadrenocorticism were especially of dermatological nature (bilateral alopecia, thin skin along with elastosis and hyperpigmentation, calcinosis cutis and muscle weakness and abdominal enlargement - „potbelly”), accompanied by polyuria and polydipsia. Blood tests performed on 14 dogs of different breed, age and gender revealed moderate hyperglycemia (143.4±3.3 mg/dl), hypercholesterolemia (332±2.9 mg/dl), increased serum alkaline phosphatase (378±3.8 UI/L), alanine aminotransferase (ALT=93.26±2.6 UI/L), aspartate aminotransferase (AST=89.72±2.3 UI/L) and abnormal plasma cortisol (50±3.5 ng/dl). Thorough ultrasonography revealed hypertrophy of the adrenal glands (2.92x1.43 cm). The histopathologic lesions include active metabolic cells (big, rich colored and strong-cored), containing lipid structures (steroids’ precursors) and metabolic inactive cells (small, dark colored, pyknotic cored or rich in heterochromatin). Hyperglycemia, polyuria / polydipsia or elevated serum alkaline phosphatase without a significant increase in serum transaminases (AST and ALT) raises suspicion of Cushing's syndrome. If these biochemical diagnostic elements evolve along with dermatological signs (bilateral alopecia, hyperpigmentation, muscle weakness), the diagnosis of Cushing's syndrome is more likely.

Keywords:
dog; hyperadrenocorticism; clinical biochemistry

Issue: 2020, Volume 71, Issue 3

Pages: 320-324

Publication date: 2020/4/3

https://doi.org/10.37358/RC.20.3.8004

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BOGHIAN, V., Clinical Biochemistry of Cushing Syndrome in Dogs, Rev. Chim., 71(3), 2020, 320-324.

Vancouver
Boghian V. Clinical Biochemistry of Cushing Syndrome in Dogs. Rev. Chim.[internet]. 2020 Mar;71(3):320-324. Available from: https://doi.org/10.37358/RC.20.3.8004

APA 6th edition
Boghian, V., (2020). Clinical Biochemistry of Cushing Syndrome in Dogs. Revista de Chimie, 71(3), 320-324. https://doi.org/10.37358/RC.20.3.8004

Harvard
Boghian, V., (2020). 'Clinical Biochemistry of Cushing Syndrome in Dogs', Revista de Chimie, 71(3), pp. 320-324. https://doi.org/10.37358/RC.20.3.8004

IEEE
V. Boghian, "Clinical Biochemistry of Cushing Syndrome in Dogs". Revista de Chimie, vol. 71, no. 3, pp. 320-324, 2020. [online]. https://doi.org/10.37358/RC.20.3.8004

Text
Vasile Boghian,
Clinical Biochemistry of Cushing Syndrome in Dogs,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 320-324,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.8004.
(https://revistadechimie.ro/Articles.asp?ID=8004)
Keywords: dog; hyperadrenocorticism; clinical biochemistry

RIS
TY - JOUR
T1 - Clinical Biochemistry of Cushing Syndrome in Dogs
A1 - Boghian, Vasile
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 320
EP - 324
UR - https://doi.org/10.37358/RC.20.3.8004
KW - dog
KW - hyperadrenocorticism
KW - clinical biochemistry
ER -

BibTex
@article{RevCh2020P320,
author = {Boghian Vasile},
title = {Clinical Biochemistry of Cushing Syndrome in Dogs},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {320-324},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.8004},
url = {https://revistadechimie.ro/Articles.asp?ID=8004}
}

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