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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 3, 287-293

https://doi.org/10.37358/RC.20.3.7999

Cristina Al Matarneh, Catalina-Ionica Ciobanu, Violeta Mangalagiu, Gheorghita Zbancioc, Ramona Danac

Microwave Assisted Synthesis of Six Member Ring Azaheterocycles and Their Antimycobacterial and Anticancer Evaluation

Abstract:

We report herein a comparative study concerning the influence of microwave (MW) irradiation comparative with conventional thermal heating (TH) in the reaction of six member ring azaheterocycles (derived from phenanthroline, quinoline, isoquinoline and phthalazine) with ethyl cyanoformate, and their anticancer and antimycobacterial activity. Under MW irradiation the reactions have some undeniable advantages: the reaction times decrease dramatically (from hours to minutes), the yields are higher, the reactions became selective in some cases (4,7-phenanthrolinium and phthalazinium ylides). The decreasing of reaction time+ from hours to minutes corroborated with the fact that in majority of cases the yield are higher and the selectivity is better, allow us to say that these reactions could be considered as eco-friendly. As far for biological activity, three of the compounds exhibited a significant antitumor activity against some cancer cell lines including prostate cancer, leukemia, renal cancer, lung cancer and breast cancer. The best potency in terms of growth inhibition of tumor cells (~45%) was shown by compound 4a against renal cancer A498 and ovarian cancer SK-OV-3 cells. The tested compounds have not shown any antimycobacterial activity against Mycobacterium tuberculosis.
Keywords:
microwave irradiation; anticancer; antimycobacterial; eco-friendly.

Issue: 2020, Volume 71, Issue 3
Pages: 287-293
Publication date: 2020/4/3
https://doi.org/10.37358/RC.20.3.7999
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MATARNEH, C.A., CIOBANU, C., MANGALAGIU, V., ZBANCIOC, G., DANAC, R., Microwave Assisted Synthesis of Six Member Ring Azaheterocycles and Their Antimycobacterial and Anticancer Evaluation, Rev. Chim., 71(3), 2020, 287-293.

Vancouver
Matarneh CA, Ciobanu C, Mangalagiu V, Zbancioc G, Danac R. Microwave Assisted Synthesis of Six Member Ring Azaheterocycles and Their Antimycobacterial and Anticancer Evaluation. Rev. Chim.[internet]. 2020 Mar;71(3):287-293. Available from: https://doi.org/10.37358/RC.20.3.7999


APA 6th edition
Matarneh, C.A., Ciobanu, C., Mangalagiu, V., Zbancioc, G. & Danac, R. (2020). Microwave Assisted Synthesis of Six Member Ring Azaheterocycles and Their Antimycobacterial and Anticancer Evaluation. Revista de Chimie, 71(3), 287-293. https://doi.org/10.37358/RC.20.3.7999


Harvard
Matarneh, C.A., Ciobanu, C., Mangalagiu, V., Zbancioc, G., Danac, R. (2020). 'Microwave Assisted Synthesis of Six Member Ring Azaheterocycles and Their Antimycobacterial and Anticancer Evaluation', Revista de Chimie, 71(3), pp. 287-293. https://doi.org/10.37358/RC.20.3.7999


IEEE
C.A. Matarneh, C. Ciobanu, V. Mangalagiu, G. Zbancioc, R. Danac, "Microwave Assisted Synthesis of Six Member Ring Azaheterocycles and Their Antimycobacterial and Anticancer Evaluation". Revista de Chimie, vol. 71, no. 3, pp. 287-293, 2020. [online]. https://doi.org/10.37358/RC.20.3.7999


Text
Cristina Al Matarneh, Catalina-Ionica Ciobanu, Violeta Mangalagiu, Gheorghita Zbancioc, Ramona Danac,
Microwave Assisted Synthesis of Six Member Ring Azaheterocycles and Their Antimycobacterial and Anticancer Evaluation,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 287-293,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.7999.
(https://revistadechimie.ro/Articles.asp?ID=7999)
Keywords: microwave irradiation; anticancer; antimycobacterial; eco-friendly.


RIS
TY - JOUR
T1 - Microwave Assisted Synthesis of Six Member Ring Azaheterocycles and Their Antimycobacterial and Anticancer Evaluation
A1 - Matarneh, Cristina Al
A2 - Ciobanu, Catalina-Ionica
A3 - Mangalagiu, Violeta
A4 - Zbancioc, Gheorghita
A5 - Danac, Ramona
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 287
EP - 293
UR - https://doi.org/10.37358/RC.20.3.7999
KW - microwave irradiation; anticancer; antimycobacterial; eco-friendly.
ER -


BibTex
@article{RevCh2020P287,
author = {Matarneh Cristina Al and Ciobanu Catalina-Ionica and Mangalagiu Violeta and Zbancioc Gheorghita and Danac Ramona},
title = {Microwave Assisted Synthesis of Six Member Ring Azaheterocycles and Their Antimycobacterial and Anticancer Evaluation},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {287-293},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.7999},
url = {https://revistadechimie.ro/Articles.asp?ID=7999}
}
 
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