The Protective Effect of IL-6 Blockade on Glucose and Cardiovascular Risk in Patients with Active Rheumatoid Arthritis

Jitaru, Alexandra; Mastaleru, Alexandra; Oancea, Andra; Zota, Madalina; Abdulan, Irina-Mihaela; Pomirleanu, Cristina; Ancuta, Codrina; Mitu, Florin

Alexandra Jitaru, Alexandra Mastaleru, Andra Oancea, Madalina Zota, Irina-Mihaela Abdulan, Cristina Pomirleanu, Codrina Ancuta, Florin Mitu

The Protective Effect of IL-6 Blockade on Glucose and Cardiovascular Risk in Patients with Active Rheumatoid Arthritis

Abstract:

Considering the multivalent role of interleukin-6 (IL-6) both in rheumatoid arthritis (RA) and in the metabolic processes, we aimed to evaluate the positive effect of subcutaneous tocilizumab (TCZ) on the probability of developing diabetes mellitus (DM). We recruited 56 consecutive patients with definite and active RA and assessed demographics, RA-related parameters and metabolic biomarkers, including the Homeostasis Model Assessment for insulin resistance (HOMA-IR) and the Quantitative Insulin Sensitivity Check Index (QUICKI). After 52 weeks of treatment, most of the patients showed a statistically significant reduction of HOMA-IR (3.61 ± 1.21 at baseline vs. 2.45 ± 1.46 at the end of the study, p[0.001), while QUICKI registered only a slight increase (0.32 ± 0.01 at baseline vs. 0.33 ± 0.01 at final evaluation, p[0.001). Our results strongly suggest that long-term IL-6 blockade has a beneficial effect in slowing the atherosclerotic process and reducing CV risk in active RA.

Keywords:
cardiovascular risk; insulin resistance; tocilizumab; metabolic parameters

Issue: 2020, Volume 71, Issue 3

Pages: 234-242

Publication date: 2020/4/3

https://doi.org/10.37358/RC.20.3.7992

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
JITARU, A., MASTALERU, A., OANCEA, A., ZOTA, M., ABDULAN, I., POMIRLEANU, C., ANCUTA, C., MITU, F., The Protective Effect of IL-6 Blockade on Glucose and Cardiovascular Risk in Patients with Active Rheumatoid Arthritis, Rev. Chim., 71(3), 2020, 234-242.

Vancouver
Jitaru A, Mastaleru A, Oancea A, Zota M, Abdulan I, Pomirleanu C, Ancuta C, Mitu F. The Protective Effect of IL-6 Blockade on Glucose and Cardiovascular Risk in Patients with Active Rheumatoid Arthritis. Rev. Chim.[internet]. 2020 Mar;71(3):234-242. Available from: https://doi.org/10.37358/RC.20.3.7992

APA 6th edition
Jitaru, A., Mastaleru, A., Oancea, A., Zota, M., Abdulan, I., Pomirleanu, C., Ancuta, C. & Mitu, F. (2020). The Protective Effect of IL-6 Blockade on Glucose and Cardiovascular Risk in Patients with Active Rheumatoid Arthritis. Revista de Chimie, 71(3), 234-242. https://doi.org/10.37358/RC.20.3.7992

Harvard
Jitaru, A., Mastaleru, A., Oancea, A., Zota, M., Abdulan, I., Pomirleanu, C., Ancuta, C., Mitu, F. (2020). 'The Protective Effect of IL-6 Blockade on Glucose and Cardiovascular Risk in Patients with Active Rheumatoid Arthritis', Revista de Chimie, 71(3), pp. 234-242. https://doi.org/10.37358/RC.20.3.7992

IEEE
A. Jitaru, A. Mastaleru, A. Oancea, M. Zota, I. Abdulan, C. Pomirleanu, C. Ancuta, F. Mitu, "The Protective Effect of IL-6 Blockade on Glucose and Cardiovascular Risk in Patients with Active Rheumatoid Arthritis". Revista de Chimie, vol. 71, no. 3, pp. 234-242, 2020. [online]. https://doi.org/10.37358/RC.20.3.7992

Text
Alexandra Jitaru, Alexandra Mastaleru, Andra Oancea, Madalina Zota, Irina-Mihaela Abdulan, Cristina Pomirleanu, Codrina Ancuta, Florin Mitu,
The Protective Effect of IL-6 Blockade on Glucose and Cardiovascular Risk in Patients with Active Rheumatoid Arthritis,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 234-242,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.7992.
(https://revistadechimie.ro/Articles.asp?ID=7992)
Keywords: cardiovascular risk; insulin resistance; tocilizumab; metabolic parameters

RIS
TY - JOUR
T1 - The Protective Effect of IL-6 Blockade on Glucose and Cardiovascular Risk in Patients with Active Rheumatoid Arthritis
A1 - Jitaru, Alexandra
A2 - Mastaleru, Alexandra
A3 - Oancea, Andra
A4 - Zota, Madalina
A5 - Abdulan, Irina-Mihaela
A6 - Pomirleanu, Cristina
A7 - Ancuta, Codrina
A8 - Mitu, Florin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 234
EP - 242
UR - https://doi.org/10.37358/RC.20.3.7992
KW - cardiovascular risk
KW - insulin resistance
KW - tocilizumab
KW - metabolic parameters
ER -

BibTex
@article{RevCh2020P234,
author = {Jitaru Alexandra and Mastaleru Alexandra and Oancea Andra and Zota Madalina and Abdulan Irina-Mihaela and Pomirleanu Cristina and Ancuta Codrina and Mitu Florin},
title = {The Protective Effect of IL-6 Blockade on Glucose and Cardiovascular Risk in Patients with Active Rheumatoid Arthritis},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {234-242},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.7992},
url = {https://revistadechimie.ro/Articles.asp?ID=7992}
}

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