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Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 3, 185-191

https://doi.org/10.37358/RC.20.3.7987

Amadeus Dobrescu, Cristi Tarta, Marioara Cornianu, Codruta Lazureanu, Ioana Golu, Sonia Tanasescu, Mihaela Iacob, Dan Brebu, Alexandru Isaic, Robert Barna, Fulger Lazar

Thyroid Transcription Factor - 1 (TTF-1) Immunoexpression in Thyroid Carcinoma with Follicular Origin

Abstract:

Differentiated thyroid carcinomas are heterogeneous diseases with clinical and morphological features insufficient to predict their clinical behavior. The expression of tissue-specific transcription factors that control differentiated phenotype can be an additional method in evaluating the aggressiveness of a tumor, when differentiation markers and malignant phenotype of tumor cells are inconclusive. The expression of thyroid transcription factor-1 (TTF-1) is limited to thyroid follicular cells; it is a nuclear protein expressed in the epithelial cells of the thyroid, lungs and diencephalon. Using the monoclonal mouse antibody, clone 8G7G3/1, we examined the immunohistochemical expression of TTF-1 protein in 26 thyroid carcinomas (22 papillary carcinomas - PTC, 2 follicular carcinomas - FTC, 2 anaplastic carcinomas - AC), 4 follicular adenomas - FA, 10 benign thyroid lesions as underlying diseases (multinodular goiter - 3, Hashimoto thyroiditis - 3, Graves Basedow disease - 4) and sections of normal thyroid tissue, assessing the possible correlations with clinical and morphological features, as well as patient outcomes.TTF-1 nuclear expression was identified in 75% of benign thyroid lesions and 18/26 (69.23%) carcinomas. We noted TTF-1 nuclear expression in 68.18% of PTC (10% being associated with recurrent disease) and the absence of immunoreaction in 31.82% of PTC without recurrent disease. In patients with PTC, the risk of recurrence was significantly associated with the presence of nuclear TTF-1 expression in the primary tumor (p[0.001), but was not influenced by the type of surgery performed (p]0.05) or patients’ age. TTF-1 nuclear expression did not correlate with patients’ gender, tumor size, extent of disease at the moment of diagnosis and multifocal tumors (p]0.05). TTF-1 nuclear reactivity can be elevated in differentiated thyroid tumors (PTC and FTC) with aggressive clinical behavior that will develop recurrent or persistent disease. In anaplastic thyroid carcinomas with fast growth rate, immunoreactivity for TTF-1 and Ki-67 can offer useful information for tumor cell differentiation, while in the case of a mixed thyroid tumor it helps in distinguishing between well differentiated and undifferentiated/anaplastic areas.
Keywords:
thyroid carcinoma; thyroid transcription factor (TTF-1); immunohistochemistry

Issue: 2020, Volume 71, Issue 3
Pages: 185-191
Publication date: 2020/4/3
https://doi.org/10.37358/RC.20.3.7987
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
DOBRESCU, A., TARTA, C., CORNIANU, M., LAZUREANU, C., GOLU, I., TANASESCU, S., IACOB, M., BREBU, D., ISAIC, A., BARNA, R., LAZAR, F., Thyroid Transcription Factor - 1 (TTF-1) Immunoexpression in Thyroid Carcinoma with Follicular Origin, Rev. Chim., 71(3), 2020, 185-191.

Vancouver
Dobrescu A, Tarta C, Cornianu M, Lazureanu C, Golu I, Tanasescu S, Iacob M, Brebu D, Isaic A, Barna R, Lazar F. Thyroid Transcription Factor - 1 (TTF-1) Immunoexpression in Thyroid Carcinoma with Follicular Origin. Rev. Chim.[internet]. 2020 Mar;71(3):185-191. Available from: https://doi.org/10.37358/RC.20.3.7987


APA 6th edition
Dobrescu, A., Tarta, C., Cornianu, M., Lazureanu, C., Golu, I., Tanasescu, S.,... Lazar, F. (2020). Thyroid Transcription Factor - 1 (TTF-1) Immunoexpression in Thyroid Carcinoma with Follicular Origin. Revista de Chimie, 71(3), 185-191. https://doi.org/10.37358/RC.20.3.7987


Harvard
Dobrescu, A., Tarta, C., Cornianu, M., Lazureanu, C., Golu, I., Tanasescu, S., Iacob, M., Brebu, D., Isaic, A., Barna, R., Lazar, F. (2020). 'Thyroid Transcription Factor - 1 (TTF-1) Immunoexpression in Thyroid Carcinoma with Follicular Origin', Revista de Chimie, 71(3), pp. 185-191. https://doi.org/10.37358/RC.20.3.7987


IEEE
A. Dobrescu, C. Tarta, M. Cornianu, C. Lazureanu, I. Golu, S. Tanasescu, M. Iacob, D. Brebu, A. Isaic, R. Barna, F. Lazar, "Thyroid Transcription Factor - 1 (TTF-1) Immunoexpression in Thyroid Carcinoma with Follicular Origin". Revista de Chimie, vol. 71, no. 3, pp. 185-191, 2020. [online]. https://doi.org/10.37358/RC.20.3.7987


Text
Amadeus Dobrescu, Cristi Tarta, Marioara Cornianu, Codruta Lazureanu, Ioana Golu, Sonia Tanasescu, Mihaela Iacob, Dan Brebu, Alexandru Isaic, Robert Barna, Fulger Lazar,
Thyroid Transcription Factor - 1 (TTF-1) Immunoexpression in Thyroid Carcinoma with Follicular Origin,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 185-191,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.7987.
(https://revistadechimie.ro/Articles.asp?ID=7987)
Keywords: thyroid carcinoma; thyroid transcription factor (TTF-1); immunohistochemistry


RIS
TY - JOUR
T1 - Thyroid Transcription Factor - 1 (TTF-1) Immunoexpression in Thyroid Carcinoma with Follicular Origin
A1 - Dobrescu, Amadeus
A2 - Tarta, Cristi
A3 - Cornianu, Marioara
A4 - Lazureanu, Codruta
A5 - Golu, Ioana
A6 - Tanasescu, Sonia
A7 - Iacob, Mihaela
A8 - Brebu, Dan
A9 - Isaic, Alexandru
A10 - Barna, Robert
A11 - Lazar, Fulger
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 185
EP - 191
UR - https://doi.org/10.37358/RC.20.3.7987
KW - thyroid carcinoma
KW - thyroid transcription factor (TTF-1)
KW - immunohistochemistry
ER -


BibTex
@article{RevCh2020P185,
author = {Dobrescu Amadeus and Tarta Cristi and Cornianu Marioara and Lazureanu Codruta and Golu Ioana and Tanasescu Sonia and Iacob Mihaela and Brebu Dan and Isaic Alexandru and Barna Robert and Lazar Fulger},
title = {Thyroid Transcription Factor - 1 (TTF-1) Immunoexpression in Thyroid Carcinoma with Follicular Origin},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {185-191},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.7987},
url = {https://revistadechimie.ro/Articles.asp?ID=7987}
}
 
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