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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 3, 116-125

https://doi.org/10.37358/RC.20.3.7979

Norina Basa, Daniela Lazar, Remus Cornea, Sorina Taban, Melania Ardelean, Alexandra Faur, Anca Tudor, Robert Barna, Adrian Goldis, Amadeus Dobrescu, Ramona Goldis, Marioara Cornianu

Expression of β-Catenin in Hepatocellular Carcinoma

Abstract:

Alteration of β-catenin expression is involved in the development and evolution of hepatocellular carcinoma (HCC); β-catenin is able to influence tumor cell proliferation. We analyzed the immunohistochemical (IHC) expression of β-catenin on a group of 32 patients diagnosed with HCC using the anti-β-catenin monoclonal antibody (clone E247). We correlated the expression of β-catenin with the proliferation index of Ki-67 (PI Ki-67), the mitotic index (MI) and other clinical and pathological features. We observed an altered β-catenin expression in 58.38% of all HCC cases. This expression was insignificantly correlated with tumor size (]5 cm) (p = 0.683), histological grade G1-G2 (p = 0.307), vascular invasion (p = 0.299) and advanced pT stage (p = 0.453); we obtained a significantly higher MI in HCC with altered β-catenin expression (p = 0.018), as compared to HCC without overexpression (1.66 ± 1.37) (p = 0.038) and a PI Ki-67 of 22.49 ± 20.1 and 28.24 ± 18.2, respectively in tumors with altered β-catenin expression with insignificant differences compared to HCC without overexpression (25.95 ± 15.2) (p = 0.682 and p = 0.731, respectively). According to the results we obtained, aberrant β-catenin expression in HCC was correlated with a high mitotic index, therefore playing an important role in tumor progression by stimulating tumor cell proliferation; non-nuclear β-catenin overexpression can have a pathological significance in HCC, especially in cases of HCC associated with hepatitis B virus (HBV) infection.
Keywords:
hepatocellular carcinoma; β-catenin; immunohistochemistry; PI Ki-67; mitotic index

Issue: 2020, Volume 71, Issue 3
Pages: 116-125
Publication date: 2020/4/3
https://doi.org/10.37358/RC.20.3.7979
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BASA, N., LAZAR, D., CORNEA, R., TABAN, S., ARDELEAN, M., FAUR, A., TUDOR, A., BARNA, R., GOLDIS, A., DOBRESCU, A., GOLDIS, R., CORNIANU, M., Expression of β-Catenin in Hepatocellular Carcinoma, Rev. Chim., 71(3), 2020, 116-125.

Vancouver
Basa N, Lazar D, Cornea R, Taban S, Ardelean M, Faur A, Tudor A, Barna R, Goldis A, Dobrescu A, Goldis R, Cornianu M. Expression of β-Catenin in Hepatocellular Carcinoma. Rev. Chim.[internet]. 2020 Mar;71(3):116-125. Available from: https://doi.org/10.37358/RC.20.3.7979


APA 6th edition
Basa, N., Lazar, D., Cornea, R., Taban, S., Ardelean, M., Faur, A.,... Cornianu, M. (2020). Expression of β-Catenin in Hepatocellular Carcinoma. Revista de Chimie, 71(3), 116-125. https://doi.org/10.37358/RC.20.3.7979


Harvard
Basa, N., Lazar, D., Cornea, R., Taban, S., Ardelean, M., Faur, A., Tudor, A., Barna, R., Goldis, A., Dobrescu, A., Goldis, R., Cornianu, M. (2020). 'Expression of β-Catenin in Hepatocellular Carcinoma', Revista de Chimie, 71(3), pp. 116-125. https://doi.org/10.37358/RC.20.3.7979


IEEE
N. Basa, D. Lazar, R. Cornea, S. Taban, M. Ardelean, A. Faur, A. Tudor, R. Barna, A. Goldis, A. Dobrescu, R. Goldis, M. Cornianu, "Expression of β-Catenin in Hepatocellular Carcinoma". Revista de Chimie, vol. 71, no. 3, pp. 116-125, 2020. [online]. https://doi.org/10.37358/RC.20.3.7979


Text
Norina Basa, Daniela Lazar, Remus Cornea, Sorina Taban, Melania Ardelean, Alexandra Faur, Anca Tudor, Robert Barna, Adrian Goldis, Amadeus Dobrescu, Ramona Goldis, Marioara Cornianu,
Expression of β-Catenin in Hepatocellular Carcinoma,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 116-125,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.7979.
(https://revistadechimie.ro/Articles.asp?ID=7979)
Keywords: hepatocellular carcinoma; β-catenin; immunohistochemistry; PI Ki-67; mitotic index


RIS
TY - JOUR
T1 - Expression of β-Catenin in Hepatocellular Carcinoma
A1 - Basa, Norina
A2 - Lazar, Daniela
A3 - Cornea, Remus
A4 - Taban, Sorina
A5 - Ardelean, Melania
A6 - Faur, Alexandra
A7 - Tudor, Anca
A8 - Barna, Robert
A9 - Goldis, Adrian
A10 - Dobrescu, Amadeus
A11 - Goldis, Ramona
A12 - Cornianu, Marioara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 116
EP - 125
UR - https://doi.org/10.37358/RC.20.3.7979
KW - hepatocellular carcinoma
KW - β-catenin
KW - immunohistochemistry
KW - PI Ki-67
KW - mitotic index
ER -


BibTex
@article{RevCh2020P116,
author = {Basa Norina and Lazar Daniela and Cornea Remus and Taban Sorina and Ardelean Melania and Faur Alexandra and Tudor Anca and Barna Robert and Goldis Adrian and Dobrescu Amadeus and Goldis Ramona and Cornianu Marioara},
title = {Expression of β-Catenin in Hepatocellular Carcinoma},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {116-125},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.7979},
url = {https://revistadechimie.ro/Articles.asp?ID=7979}
}
 
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