Development and Validation of Hplc-Dad Method for Diclofenac Sodium Assay from New Orodispersible Tablets with Co-Processed Excipients

Rosca, Adrian Cosmin; Roncea, Florentina Nicoleta; Iancu, Valeriu; Stoicescu, Iuliana; Cazacincu, Radu; Iancu, Irina; Miresan, Horatiu

Adrian Cosmin Rosca, Florentina Nicoleta Roncea, Valeriu Iancu, Iuliana Stoicescu, Radu Cazacincu, Irina Iancu, Horatiu Miresan

Development and Validation of Hplc-Dad Method for Diclofenac Sodium Assay from New Orodispersible Tablets with Co-Processed Excipients

Abstract:

The aim of this study is to develop and validate a reliable, fast, and precise High-performance liquid chromatography (HPLC) method for the assay of diclofenac sodium (DIC) from previously optimized new orodispersible tablets (ODTs) developed with co-processed excipients.The method was conducted on an HPLC Agilent 1200, Zorbax C18 column, mobile phase of orthophosphoric acid solutions 0.1%, acetonitrile and methanol in the ratio (40:50:10 v/v/v) with a flow rate of 1.5 mL/min with isocratic elution and a total run time of 5 min. Detection of diclofenac sodium was carried out at 276 nm. The method was validated for linearity, precision, accuracy, robustness as per international guidelines. The developed method was found to be accurate, precise, fast, without interference from the co-processed excipients and can be useful for routine quality control analysis of diclofenac sodium in ODTs.

Keywords:
HPLC-DAD; validation; diclofenac sodium; co-processed excipients; orodispersible tablets

Issue: 2020, Volume 71, Issue 2

Pages: 335-342

Publication date: 2020/3/3

https://doi.org/10.37358/RC.20.2.7934

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ROSCA, A.C., RONCEA, F.N., IANCU, V., STOICESCU, I., CAZACINCU, R., IANCU, I., MIRESAN, H., Development and Validation of Hplc-Dad Method for Diclofenac Sodium Assay from New Orodispersible Tablets with Co-Processed Excipients, Rev. Chim., 71(2), 2020, 335-342.

Vancouver
Rosca AC, Roncea FN, Iancu V, Stoicescu I, Cazacincu R, Iancu I, Miresan H. Development and Validation of Hplc-Dad Method for Diclofenac Sodium Assay from New Orodispersible Tablets with Co-Processed Excipients. Rev. Chim.[internet]. 2020 Feb;71(2):335-342. Available from: https://doi.org/10.37358/RC.20.2.7934

APA 6th edition
Rosca, A.C., Roncea, F.N., Iancu, V., Stoicescu, I., Cazacincu, R., Iancu, I. & Miresan, H. (2020). Development and Validation of Hplc-Dad Method for Diclofenac Sodium Assay from New Orodispersible Tablets with Co-Processed Excipients. Revista de Chimie, 71(2), 335-342. https://doi.org/10.37358/RC.20.2.7934

Harvard
Rosca, A.C., Roncea, F.N., Iancu, V., Stoicescu, I., Cazacincu, R., Iancu, I., Miresan, H. (2020). 'Development and Validation of Hplc-Dad Method for Diclofenac Sodium Assay from New Orodispersible Tablets with Co-Processed Excipients', Revista de Chimie, 71(2), pp. 335-342. https://doi.org/10.37358/RC.20.2.7934

IEEE
A.C. Rosca, F.N. Roncea, V. Iancu, I. Stoicescu, R. Cazacincu, I. Iancu, H. Miresan, "Development and Validation of Hplc-Dad Method for Diclofenac Sodium Assay from New Orodispersible Tablets with Co-Processed Excipients". Revista de Chimie, vol. 71, no. 2, pp. 335-342, 2020. [online]. https://doi.org/10.37358/RC.20.2.7934

Text
Adrian Cosmin Rosca, Florentina Nicoleta Roncea, Valeriu Iancu, Iuliana Stoicescu, Radu Cazacincu, Irina Iancu, Horatiu Miresan,
Development and Validation of Hplc-Dad Method for Diclofenac Sodium Assay from New Orodispersible Tablets with Co-Processed Excipients,
Revista de Chimie,
Volume 71, Issue 2,
2020,
Pages 335-342,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.2.7934.
(https://revistadechimie.ro/Articles.asp?ID=7934)
Keywords: HPLC-DAD; validation; diclofenac sodium; co-processed excipients; orodispersible tablets

RIS
TY - JOUR
T1 - Development and Validation of Hplc-Dad Method for Diclofenac Sodium Assay from New Orodispersible Tablets with Co-Processed Excipients
A1 - Rosca, Adrian Cosmin
A2 - Roncea, Florentina Nicoleta
A3 - Iancu, Valeriu
A4 - Stoicescu, Iuliana
A5 - Cazacincu, Radu
A6 - Iancu, Irina
A7 - Miresan, Horatiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 2
SP - 335
EP - 342
UR - https://doi.org/10.37358/RC.20.2.7934
KW - HPLC-DAD
KW - validation
KW - diclofenac sodium
KW - co-processed excipients
KW - orodispersible tablets
ER -

BibTex
@article{RevCh2020P335,
author = {Rosca Adrian Cosmin and Roncea Florentina Nicoleta and Iancu Valeriu and Stoicescu Iuliana and Cazacincu Radu and Iancu Irina and Miresan Horatiu},
title = {Development and Validation of Hplc-Dad Method for Diclofenac Sodium Assay from New Orodispersible Tablets with Co-Processed Excipients},
journal = {Revista de Chimie},
volume = {71},
number = {2},
pages = {335-342},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.2.7934},
url = {https://revistadechimie.ro/Articles.asp?ID=7934}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)