Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy

Simon, Catalin Petru; Bratu, Dana Cristina; Motoc, Andrei Gheorghe Marius; Popa, George; Pop, Izabella Silvia; Mederle, Ovidiu Alexandru

Catalin Petru Simon, Dana Cristina Bratu, Andrei Gheorghe Marius Motoc, George Popa, Izabella Silvia Pop, Ovidiu Alexandru Mederle

Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy

Abstract:

Our study started from the hypothesis that the gingival volume growth associated with fixed orthodontic treatment appeared during the use of leveling and aligning archwires, without any inflammatory signs, as a result of the mechanical stress and periodontal remodeling during the orthodontic dental movement.We selected and included in the study 35 patients (13 females and 12 males) between 12 and 38 years of age, all suffering from gingival overgrowth, diagnosed during the active treatment with fixed orthodontic appliances (braces). For each patient, two tissue samples were taken: one in the early stages of the lesion, coinciding with the use of leveling and aligning archwires and another in the late stages of the lesion, coinciding with the use of finishing archwires. The samples were taken from the same site in the oral cavity. Out of 35 gingival biopsies taken from patients, 8 cases showed no significant changes in the gingiva, while in the remaining 27 cases, significant changes were found after the histopathological exam.Out of 27 gingival biopsies, 16 cases presented a significantly greater number of T cells. In addition, a greater number of B cells were observed in the granulation tissues than in the gingiva. The relative number of B cells (CD20), T cells and dendritic cells (CD8) has been expressed, both in the early and the late stages of the gingival lesions. Our results revealed that the proportion of T lymphocytes and dendritic cells was greater in the early stages rather than at the late stages. The B cells showed a higher count in the late stages.

Keywords:
immunohistochemistry; histopathology; gingival overgrowth; fixed orthodontic treatment

Issue: 2020, Volume 71, Issue 2

Pages: 302-306

Publication date: 2020/3/3

https://doi.org/10.37358/RC.20.2.7929

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SIMON, C.P., BRATU, D.C., MOTOC, A.G.M., POPA, G., POP, I.S., MEDERLE, O.A., Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy, Rev. Chim., 71(2), 2020, 302-306.

Vancouver
Simon CP, Bratu DC, Motoc AGM, Popa G, Pop IS, Mederle OA. Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy. Rev. Chim.[internet]. 2020 Feb;71(2):302-306. Available from: https://doi.org/10.37358/RC.20.2.7929

APA 6th edition
Simon, C.P., Bratu, D.C., Motoc, A.G.M., Popa, G., Pop, I.S. & Mederle, O.A. (2020). Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy. Revista de Chimie, 71(2), 302-306. https://doi.org/10.37358/RC.20.2.7929

Harvard
Simon, C.P., Bratu, D.C., Motoc, A.G.M., Popa, G., Pop, I.S., Mederle, O.A. (2020). 'Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy', Revista de Chimie, 71(2), pp. 302-306. https://doi.org/10.37358/RC.20.2.7929

IEEE
C.P. Simon, D.C. Bratu, A.G.M. Motoc, G. Popa, I.S. Pop, O.A. Mederle, "Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy". Revista de Chimie, vol. 71, no. 2, pp. 302-306, 2020. [online]. https://doi.org/10.37358/RC.20.2.7929

Text
Catalin Petru Simon, Dana Cristina Bratu, Andrei Gheorghe Marius Motoc, George Popa, Izabella Silvia Pop, Ovidiu Alexandru Mederle,
Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy,
Revista de Chimie,
Volume 71, Issue 2,
2020,
Pages 302-306,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.2.7929.
(https://revistadechimie.ro/Articles.asp?ID=7929)
Keywords: immunohistochemistry; histopathology; gingival overgrowth; fixed orthodontic treatment

RIS
TY - JOUR
T1 - Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy
A1 - Simon, Catalin Petru
A2 - Bratu, Dana Cristina
A3 - Motoc, Andrei Gheorghe Marius
A4 - Popa, George
A5 - Pop, Izabella Silvia
A6 - Mederle, Ovidiu Alexandru
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 2
SP - 302
EP - 306
UR - https://doi.org/10.37358/RC.20.2.7929
KW - immunohistochemistry
KW - histopathology
KW - gingival overgrowth
KW - fixed orthodontic treatment
ER -

BibTex
@article{RevCh2020P302,
author = {Simon Catalin Petru and Bratu Dana Cristina and Motoc Andrei Gheorghe Marius and Popa George and Pop Izabella Silvia and Mederle Ovidiu Alexandru},
title = {Immunohistochemical Analysis of Gingival Proliferative Processes Associated with Fixed Orthodontic Therapy},
journal = {Revista de Chimie},
volume = {71},
number = {2},
pages = {302-306},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.2.7929},
url = {https://revistadechimie.ro/Articles.asp?ID=7929}
}

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