The Importance of Neutrophil to Lymphocyte Ratio and  Platelet to Lymphocyte Ratio in Predicting the Appearance of the Rectal Stenosis or Rectal Obstruction in Patients with Rectal Adenocarcinomas

Halmaciu, Ioana; Suciu, Bogdan Andrei; Vunvulea, Vlad; Muresan, Mircea Gabriel; Scarlat, Florentina Cristina; Molnar, Calin; Bacalbasa, Nicolae; Brinzaniuc, Klara; Voidazan, Septimiu

Ioana Halmaciu, Bogdan Andrei Suciu, Vlad Vunvulea, Mircea Gabriel Muresan, Florentina Cristina Scarlat, Calin Molnar, Nicolae Bacalbasa, Klara Brinzaniuc, Septimiu Voidazan

The Importance of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting the Appearance of the Rectal Stenosis or Rectal Obstruction in Patients with Rectal Adenocarcinomas

Abstract:

The purpose of this study was to establish a correlation between markers of inflammation and the risk of rectal stenosis or obstruction, in patients with rectal adenocarcinomas. We performed a retrospective observational study on 188 patients diagnosed with rectal adenocarcinomas. We attempted to establish a correlation between the neutrophils to lymphocyte ratio(NLR), platelet to lymphocyte ratio(PLR) levels and the presence of rectal stenosis or rectal obstruction. From 188 patients included in the study, 65 patients had stenotic tumors (34.57% of cases) and 10 patients had occlusive tumors (5.31% of cases). We obtained a statistically significant correlation between the blood levels of neutrophils, lymphocytes, platelets, and the existence of rectal stenosis. (p[0.05). The cutoff value of NLR that correlates with the presence of rectal stenosis was 2.5 (95% CI: 0.426-0.574, AUC: 0.500). As for PLR, the cutoff value correlated with the presence of rectal stenosis was 106,522 (95%CI: 0.428-0.575, AUC: 0.502). We established a statistically significant correlation between NLR, PLR and rectal obstruction (p[0.05). The cutoff value of the NLR that correlates with the presence of rectal obstruction was 4.633 (95%CI: 0.614-0.751, AUC: 0.685). As for PLR, the cutoff value correlated with the presence of rectal stenosis was 345.05 (95% CI: 0.673-0.803, AUC: 0.742). Our study shows that there is a statistically significant correlation between NLR and PLR and the risk of rectal obstruction in patients with adenocarcinomas. It is still necessary to conduct prospective studies on much larger lots of patients to determine the NLR and PLR values that can predict rectal stenosis as well as rectal obstruction.

Keywords:
neutrophil to lymphocyte ratio; platelet to lymphocyte ratio; rectal adenocarcinoma

Issue: 2020, Volume 71, Issue 2

Pages: 239-247

Publication date: 2020/3/3

https://doi.org/10.37358/RC.20.2.7921

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
HALMACIU, I., SUCIU, B.A., VUNVULEA, V., MURESAN, M.G., SCARLAT, F.C., MOLNAR, C., BACALBASA, N., BRINZANIUC, K., VOIDAZAN, S., The Importance of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting the Appearance of the Rectal Stenosis or Rectal Obstruction in Patients with Rectal Adenocarcinomas, Rev. Chim., 71(2), 2020, 239-247.

Vancouver
Halmaciu I, Suciu BA, Vunvulea V, Muresan MG, Scarlat FC, Molnar C, Bacalbasa N, Brinzaniuc K, Voidazan S. The Importance of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting the Appearance of the Rectal Stenosis or Rectal Obstruction in Patients with Rectal Adenocarcinomas. Rev. Chim.[internet]. 2020 Feb;71(2):239-247. Available from: https://doi.org/10.37358/RC.20.2.7921

APA 6th edition
Halmaciu, I., Suciu, B.A., Vunvulea, V., Muresan, M.G., Scarlat, F.C., Molnar, C.,... Voidazan, S. (2020). The Importance of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting the Appearance of the Rectal Stenosis or Rectal Obstruction in Patients with Rectal Adenocarcinomas. Revista de Chimie, 71(2), 239-247. https://doi.org/10.37358/RC.20.2.7921

Harvard
Halmaciu, I., Suciu, B.A., Vunvulea, V., Muresan, M.G., Scarlat, F.C., Molnar, C., Bacalbasa, N., Brinzaniuc, K., Voidazan, S. (2020). 'The Importance of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting the Appearance of the Rectal Stenosis or Rectal Obstruction in Patients with Rectal Adenocarcinomas', Revista de Chimie, 71(2), pp. 239-247. https://doi.org/10.37358/RC.20.2.7921

IEEE
I. Halmaciu, B.A. Suciu, V. Vunvulea, M.G. Muresan, F.C. Scarlat, C. Molnar, N. Bacalbasa, K. Brinzaniuc, S. Voidazan, "The Importance of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting the Appearance of the Rectal Stenosis or Rectal Obstruction in Patients with Rectal Adenocarcinomas". Revista de Chimie, vol. 71, no. 2, pp. 239-247, 2020. [online]. https://doi.org/10.37358/RC.20.2.7921

Text
Ioana Halmaciu, Bogdan Andrei Suciu, Vlad Vunvulea, Mircea Gabriel Muresan, Florentina Cristina Scarlat, Calin Molnar, Nicolae Bacalbasa, Klara Brinzaniuc, Septimiu Voidazan,
The Importance of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting the Appearance of the Rectal Stenosis or Rectal Obstruction in Patients with Rectal Adenocarcinomas,
Revista de Chimie,
Volume 71, Issue 2,
2020,
Pages 239-247,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.2.7921.
(https://revistadechimie.ro/Articles.asp?ID=7921)
Keywords: neutrophil to lymphocyte ratio; platelet to lymphocyte ratio; rectal adenocarcinoma

RIS
TY - JOUR
T1 - The Importance of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting the Appearance of the Rectal Stenosis or Rectal Obstruction in Patients with Rectal Adenocarcinomas
A1 - Halmaciu, Ioana
A2 - Suciu, Bogdan Andrei
A3 - Vunvulea, Vlad
A4 - Muresan, Mircea Gabriel
A5 - Scarlat, Florentina Cristina
A6 - Molnar, Calin
A7 - Bacalbasa, Nicolae
A8 - Brinzaniuc, Klara
A9 - Voidazan, Septimiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 2
SP - 239
EP - 247
UR - https://doi.org/10.37358/RC.20.2.7921
KW - neutrophil to lymphocyte ratio
KW - platelet to lymphocyte ratio
KW - rectal adenocarcinoma
ER -

BibTex
@article{RevCh2020P239,
author = {Halmaciu Ioana and Suciu Bogdan Andrei and Vunvulea Vlad and Muresan Mircea Gabriel and Scarlat Florentina Cristina and Molnar Calin and Bacalbasa Nicolae and Brinzaniuc Klara and Voidazan Septimiu},
title = {The Importance of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting the Appearance of the Rectal Stenosis or Rectal Obstruction in Patients with Rectal Adenocarcinomas},
journal = {Revista de Chimie},
volume = {71},
number = {2},
pages = {239-247},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.2.7921},
url = {https://revistadechimie.ro/Articles.asp?ID=7921}
}

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