Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems

Ene, Vladimir Lucian; Neacsu, Ionela Andreea; Oprea, Ovidiu; Surdu, Vasile Adrian; Trusca, Roxana Doina; Ficai, Anton; Andronescu, Ecaterina

Vladimir Lucian Ene, Ionela Andreea Neacsu, Ovidiu Oprea, Vasile Adrian Surdu, Roxana Doina Trusca, Anton Ficai, Ecaterina Andronescu

Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems

Abstract:

This paper aims to improve medical strategies regarding cancer treatment, by developing new targeted cancer therapy nanostructured systems, based on magnetite and natural catabolism products as coating agents (glutamic acid, tartaric acid), with induced cellular internalization. In order to create hydrophilic, biocompatible systems, suitable for targeted cancer therapy, and minimize the negative side effects of current approaches, a one-pot synthesis by co-precipitation technique, starting from Fe2+ and Fe3+ inorganic precursors and multifunctional organic compounds, carefully controlling the reaction parameters (concentration of precursors, pH, temperature etc.) was performed. The obtained Fe3O4 stabilised nanoparticles were subjected to morphological and structural characterization. The formation of inorganic-organic hybrid systems was evaluated using FTIR spectroscopy and complex thermal analysis (TG / DSC) for determining the content of the organic component, while X-ray Diffractometry and Scanning and Transmission Electron Microscopy were used to characterize the crystallinity and particle dimensions and distribution. The magnetic properties at room temperature were also evaluated, recording the magnetic susceptibility relative to the applied magnetic field.

Keywords:
magnetite; glutamic acid; tartaric acid; stabilised magnetic nanoparticles

Issue: 2020, Volume 71, Issue 2

Pages: 230-238

Publication date: 2020/3/3

https://doi.org/10.37358/RC.20.2.7920

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ENE, V.L., NEACSU, I.A., OPREA, O., SURDU, V.A., TRUSCA, R.D., FICAI, A., ANDRONESCU, E., Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems, Rev. Chim., 71(2), 2020, 230-238.

Vancouver
Ene VL, Neacsu IA, Oprea O, Surdu VA, Trusca RD, Ficai A, Andronescu E. Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems. Rev. Chim.[internet]. 2020 Feb;71(2):230-238. Available from: https://doi.org/10.37358/RC.20.2.7920

APA 6th edition
Ene, V.L., Neacsu, I.A., Oprea, O., Surdu, V.A., Trusca, R.D., Ficai, A. & Andronescu, E. (2020). Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems. Revista de Chimie, 71(2), 230-238. https://doi.org/10.37358/RC.20.2.7920

Harvard
Ene, V.L., Neacsu, I.A., Oprea, O., Surdu, V.A., Trusca, R.D., Ficai, A., Andronescu, E. (2020). 'Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems', Revista de Chimie, 71(2), pp. 230-238. https://doi.org/10.37358/RC.20.2.7920

IEEE
V.L. Ene, I.A. Neacsu, O. Oprea, V.A. Surdu, R.D. Trusca, A. Ficai, E. Andronescu, "Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems". Revista de Chimie, vol. 71, no. 2, pp. 230-238, 2020. [online]. https://doi.org/10.37358/RC.20.2.7920

Text
Vladimir Lucian Ene, Ionela Andreea Neacsu, Ovidiu Oprea, Vasile Adrian Surdu, Roxana Doina Trusca, Anton Ficai, Ecaterina Andronescu,
Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems,
Revista de Chimie,
Volume 71, Issue 2,
2020,
Pages 230-238,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.2.7920.
(https://revistadechimie.ro/Articles.asp?ID=7920)
Keywords: magnetite; glutamic acid; tartaric acid; stabilised magnetic nanoparticles

RIS
TY - JOUR
T1 - Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems
A1 - Ene, Vladimir Lucian
A2 - Neacsu, Ionela Andreea
A3 - Oprea, Ovidiu
A4 - Surdu, Vasile Adrian
A5 - Trusca, Roxana Doina
A6 - Ficai, Anton
A7 - Andronescu, Ecaterina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 2
SP - 230
EP - 238
UR - https://doi.org/10.37358/RC.20.2.7920
KW - magnetite
KW - glutamic acid
KW - tartaric acid; stabilised magnetic nanoparticles
ER -

BibTex
@article{RevCh2020P230,
author = {Ene Vladimir Lucian and Neacsu Ionela Andreea and Oprea Ovidiu and Surdu Vasile Adrian and Trusca Roxana Doina and Ficai Anton and Andronescu Ecaterina},
title = {Single Step Synthesis of Glutamic/tartaric Acid-stabilised Fe3O4 Nanoparticles for Targeted Delivery Systems},
journal = {Revista de Chimie},
volume = {71},
number = {2},
pages = {230-238},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.2.7920},
url = {https://revistadechimie.ro/Articles.asp?ID=7920}
}

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