Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease

Cristache, Corina Marilena; Totu, Eugenia Eftimie; Burlibasa, Mihai; Tanase, Gabriela; Iorgulescu, Gabriela; Burlibasa, Liliana

Corina Marilena Cristache, Eugenia Eftimie Totu, Mihai Burlibasa, Gabriela Tanase, Gabriela Iorgulescu, Liliana Burlibasa

Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease

Abstract:

The aim of the present study was to assess the genotoxicity of three different antibacterial, antioxidant and anti-inflammatory mixtures: tetracycline (T) with metronidazole (MZ), melatonin (MEL) with hyaluronic acid (HA), and T+MZ+MEL+HA, in order to choose the best formulation to be used as topic treatment for periodontal disease. In vitro Micronucleus Test was performed (MTvit) according to Organization for Economic Cooperation and Development (OECD) 487 recommendations, in a blind mode, without knowing the composition of the powders evaluated. The highest cytotoxicity and incidence of MN was observed in T+MZ mixture and the mixed compounds T+MZ+MEL+HA, 1 mg/mL in the cell culture, registered the lowest incidence of micronuclei, meaning the lowest cytotoxicity, comparable to the negative control sample. Based on the present findings and previously published results, it can be concluded that the complex mixture T, MZ, MEL and HA showed excellent cytotoxicity profiles, with lower rate of chromosomal damage risk, and therefore, is recommended for safe use as topical treatment in periodontal disease.

Keywords:
cytotoxicity; melatonin; hyaluronic acid; tetracycline; metronidazole; periodontal disease

Issue: 2020, Volume 71, Issue 2

Pages: 145-150

Publication date: 2020/3/3

https://doi.org/10.37358/RC.20.2.7907

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CRISTACHE, C.M., TOTU, E.E., BURLIBASA, M., TANASE, G., IORGULESCU, G., BURLIBASA, L., Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease, Rev. Chim., 71(2), 2020, 145-150.

Vancouver
Cristache CM, Totu EE, Burlibasa M, Tanase G, Iorgulescu G, Burlibasa L. Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease. Rev. Chim.[internet]. 2020 Feb;71(2):145-150. Available from: https://doi.org/10.37358/RC.20.2.7907

APA 6th edition
Cristache, C.M., Totu, E.E., Burlibasa, M., Tanase, G., Iorgulescu, G. & Burlibasa, L. (2020). Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease. Revista de Chimie, 71(2), 145-150. https://doi.org/10.37358/RC.20.2.7907

Harvard
Cristache, C.M., Totu, E.E., Burlibasa, M., Tanase, G., Iorgulescu, G., Burlibasa, L. (2020). 'Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease', Revista de Chimie, 71(2), pp. 145-150. https://doi.org/10.37358/RC.20.2.7907

IEEE
C.M. Cristache, E.E. Totu, M. Burlibasa, G. Tanase, G. Iorgulescu, L. Burlibasa, "Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease". Revista de Chimie, vol. 71, no. 2, pp. 145-150, 2020. [online]. https://doi.org/10.37358/RC.20.2.7907

Text
Corina Marilena Cristache, Eugenia Eftimie Totu, Mihai Burlibasa, Gabriela Tanase, Gabriela Iorgulescu, Liliana Burlibasa,
Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease,
Revista de Chimie,
Volume 71, Issue 2,
2020,
Pages 145-150,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.2.7907.
(https://revistadechimie.ro/Articles.asp?ID=7907)
Keywords: cytotoxicity; melatonin; hyaluronic acid; tetracycline; metronidazole; periodontal disease

RIS
TY - JOUR
T1 - Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease
A1 - Cristache, Corina Marilena
A2 - Totu, Eugenia Eftimie
A3 - Burlibasa, Mihai
A4 - Tanase, Gabriela
A5 - Iorgulescu, Gabriela
A6 - Burlibasa, Liliana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 2
SP - 145
EP - 150
UR - https://doi.org/10.37358/RC.20.2.7907
KW - cytotoxicity
KW - melatonin
KW - hyaluronic acid
KW - tetracycline
KW - metronidazole
KW - periodontal disease
ER -

BibTex
@article{RevCh2020P145,
author = {Cristache Corina Marilena and Totu Eugenia Eftimie and Burlibasa Mihai and Tanase Gabriela and Iorgulescu Gabriela and Burlibasa Liliana},
title = {Preliminary Study on Genotoxicity Assessment of an Innovative Topical Treatment for Periodontal Disease},
journal = {Revista de Chimie},
volume = {71},
number = {2},
pages = {145-150},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.2.7907},
url = {https://revistadechimie.ro/Articles.asp?ID=7907}
}

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