An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line

Minda, Daliana; Avram, Stefana; Pavel, Ioana Zinuca; Kis, Brigitta; Ghitu, Alexandra; Zupko, Istvan; Dehelean, Cristina; Buda, Valentina; Diaconeasa, Zorita; Scurtu, Alexandra; Vlad, Alexa; Danciu, Corina

Daliana Minda, Stefana Avram, Ioana Zinuca Pavel, Brigitta Kis, Alexandra Ghitu, Istvan Zupko, Cristina Dehelean, Valentina Buda, Zorita Diaconeasa, Alexandra Scurtu, Alexa Vlad, Corina Danciu

An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line

Abstract:

pigenin (API) is a phytocompound belonging to the subclass of flavones that can be found in both functional foods as well as medicinal plants. Recent studies have assigned API antioxidant, anti-inflammatory, anti-spasmodic, anti-viral, anti-thrombotic, anti-angiogenic and chemopreventive potential in vitro on various cell lines and/or in experimental animal models. Apigenin-7-O-glucoside (API-7) is one of its main glycosides and can be commonly found in chamomile flowers, parsley, celery. The aim of this study was to evaluate the in vitro anti-proliferative and pro-apoptotic effects of API and its glycoside (apigenin-7-O-glucoside) against HeLa human cervical cancer cells. Results have shown that in the set experimental conditions both the aglycone as well as the heteroside elicit antiproliferative and pro-apoptotic potential against the screened cell line, the aglycone being more active than the heteroside.

Keywords:
apigenin ; apigenin-7-O-glucoside; HeLa cells; proliferation; apoptosis

Issue: 2020, Volume 71, Issue 2

Pages: 140-144

Publication date: 2020/3/3

https://doi.org/10.37358/RC.20.2.7906

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MINDA, D., AVRAM, S., PAVEL, I.Z., KIS, B., GHITU, A., ZUPKO, I., DEHELEAN, C., BUDA, V., DIACONEASA, Z., SCURTU, A., VLAD, A., DANCIU, C., An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line, Rev. Chim., 71(2), 2020, 140-144.

Vancouver
Minda D, Avram S, Pavel IZ, Kis B, Ghitu A, Zupko I, Dehelean C, Buda V, Diaconeasa Z, Scurtu A, Vlad A, Danciu C. An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line. Rev. Chim.[internet]. 2020 Feb;71(2):140-144. Available from: https://doi.org/10.37358/RC.20.2.7906

APA 6th edition
Minda, D., Avram, S., Pavel, I.Z., Kis, B., Ghitu, A., Zupko, I.,... Danciu, C. (2020). An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line. Revista de Chimie, 71(2), 140-144. https://doi.org/10.37358/RC.20.2.7906

Harvard
Minda, D., Avram, S., Pavel, I.Z., Kis, B., Ghitu, A., Zupko, I., Dehelean, C., Buda, V., Diaconeasa, Z., Scurtu, A., Vlad, A., Danciu, C. (2020). 'An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line', Revista de Chimie, 71(2), pp. 140-144. https://doi.org/10.37358/RC.20.2.7906

IEEE
D. Minda, S. Avram, I.Z. Pavel, B. Kis, A. Ghitu, I. Zupko, C. Dehelean, V. Buda, Z. Diaconeasa, A. Scurtu, A. Vlad, C. Danciu, "An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line". Revista de Chimie, vol. 71, no. 2, pp. 140-144, 2020. [online]. https://doi.org/10.37358/RC.20.2.7906

Text
Daliana Minda, Stefana Avram, Ioana Zinuca Pavel, Brigitta Kis, Alexandra Ghitu, Istvan Zupko, Cristina Dehelean, Valentina Buda, Zorita Diaconeasa, Alexandra Scurtu, Alexa Vlad, Corina Danciu,
An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line,
Revista de Chimie,
Volume 71, Issue 2,
2020,
Pages 140-144,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.2.7906.
(https://revistadechimie.ro/Articles.asp?ID=7906)
Keywords: apigenin ; apigenin-7-O-glucoside; HeLa cells; proliferation; apoptosis

RIS
TY - JOUR
T1 - An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line
A1 - Minda, Daliana
A2 - Avram, Stefana
A3 - Pavel, Ioana Zinuca
A4 - Kis, Brigitta
A5 - Ghitu, Alexandra
A6 - Zupko, Istvan
A7 - Dehelean, Cristina
A8 - Buda, Valentina
A9 - Diaconeasa, Zorita
A10 - Scurtu, Alexandra
A11 - Vlad, Alexa
A12 - Danciu, Corina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 2
SP - 140
EP - 144
UR - https://doi.org/10.37358/RC.20.2.7906
KW - apigenin
KW - apigenin-7-O-glucoside
KW - HeLa cells
KW - proliferation
KW - apoptosis
ER -

BibTex
@article{RevCh2020P140,
author = {Minda Daliana and Avram Stefana and Pavel Ioana Zinuca and Kis Brigitta and Ghitu Alexandra and Zupko Istvan and Dehelean Cristina and Buda Valentina and Diaconeasa Zorita and Scurtu Alexandra and Vlad Alexa and Danciu Corina},
title = {An in vitro Evaluation of Apigenin and Apigenin-7-O-glucoside Against HeLa Human Cervical Cancer Cell Line},
journal = {Revista de Chimie},
volume = {71},
number = {2},
pages = {140-144},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.2.7906},
url = {https://revistadechimie.ro/Articles.asp?ID=7906}
}

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