Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets

Moisa, Corina; Tit, Delia Mirela; Uivarosan, Diana; Cadar, Oana; Moleriu, Lavinia Cristina; Cioca, Gabriela; Mosteanu, Danut-Eugeniu; Aleya, Lotfi; Bungau, Simona

Corina Moisa, Delia Mirela Tit, Diana Uivarosan, Oana Cadar, Lavinia Cristina Moleriu, Gabriela Cioca, Danut-Eugeniu Mosteanu, Lotfi Aleya, Simona Bungau

Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets

Abstract:

Modern lifestyle, excessive chemicalization of agricultural products, excessive processing and refining of food, cause a decrease in daily intake of magnesium, cation with an extremely important role in prevention and treatment of many diseases. As a result, there arises the need for extra magnesium intake in the form of dietary supplements. In this study were evaluated the physical and chemical stability of magnesium-containing tablets, depending on the active compound and the excipients used. Magnesium tablets in the form of orotate, lactate, citrate, oxide and hydroxide were taken into study and physical and chemical stability were observed over the validity period, at 6 and at 12 months after expiry date. There were no changes in physical and chemical stability during the validity period of the studied tablets. At 6 months after the expiry date, were observed variations in chemical composition with decrease in magnesium concentration to 98% of the declared value, only in the case of tablets containing magnesium lactate. At 12 months, the magnesium concentration decreased in all analysed samples, with no statistically significant differences (p[0.05) between the types of magnesium compounds - 95% for the orotate, 93% for the lactate, 90% for the oxide and hydroxide, respectively 85% for citrate. The results of this study indicate the therapeutically safety for using these tablets 6 months after the expiry date.

Keywords:
tablets; magnesium compounds; physicochemical stability; validity period

Issue: 2020, Volume 71, Issue 2

Pages: 22-29

Publication date: 2020/3/3

https://doi.org/10.37358/RC.20.2.7886

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MOISA, C., TIT, D.M., UIVAROSAN, D., CADAR, O., MOLERIU, L.C., CIOCA, G., MOSTEANU, D., ALEYA, L., BUNGAU, S., Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets, Rev. Chim., 71(2), 2020, 22-29.

Vancouver
Moisa C, Tit DM, Uivarosan D, Cadar O, Moleriu LC, Cioca G, Mosteanu D, Aleya L, Bungau S. Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets. Rev. Chim.[internet]. 2020 Feb;71(2):22-29. Available from: https://doi.org/10.37358/RC.20.2.7886

APA 6th edition
Moisa, C., Tit, D.M., Uivarosan, D., Cadar, O., Moleriu, L.C., Cioca, G.,... Bungau, S. (2020). Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets. Revista de Chimie, 71(2), 22-29. https://doi.org/10.37358/RC.20.2.7886

Harvard
Moisa, C., Tit, D.M., Uivarosan, D., Cadar, O., Moleriu, L.C., Cioca, G., Mosteanu, D., Aleya, L., Bungau, S. (2020). 'Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets', Revista de Chimie, 71(2), pp. 22-29. https://doi.org/10.37358/RC.20.2.7886

IEEE
C. Moisa, D.M. Tit, D. Uivarosan, O. Cadar, L.C. Moleriu, G. Cioca, D. Mosteanu, L. Aleya, S. Bungau, "Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets". Revista de Chimie, vol. 71, no. 2, pp. 22-29, 2020. [online]. https://doi.org/10.37358/RC.20.2.7886

Text
Corina Moisa, Delia Mirela Tit, Diana Uivarosan, Oana Cadar, Lavinia Cristina Moleriu, Gabriela Cioca, Danut-Eugeniu Mosteanu, Lotfi Aleya, Simona Bungau,
Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets,
Revista de Chimie,
Volume 71, Issue 2,
2020,
Pages 22-29,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.2.7886.
(https://revistadechimie.ro/Articles.asp?ID=7886)
Keywords: tablets; magnesium compounds; physicochemical stability; validity period

RIS
TY - JOUR
T1 - Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets
A1 - Moisa, Corina
A2 - Tit, Delia Mirela
A3 - Uivarosan, Diana
A4 - Cadar, Oana
A5 - Moleriu, Lavinia Cristina
A6 - Cioca, Gabriela
A7 - Mosteanu, Danut-Eugeniu
A8 - Aleya, Lotfi
A9 - Bungau, Simona
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 2
SP - 22
EP - 29
UR - https://doi.org/10.37358/RC.20.2.7886
KW - tablets
KW - magnesium compounds
KW - physicochemical stability
KW - validity period
ER -

BibTex
@article{RevCh2020P22,
author = {Moisa Corina and Tit Delia Mirela and Uivarosan Diana and Cadar Oana and Moleriu Lavinia Cristina and Cioca Gabriela and Mosteanu Danut-Eugeniu and Aleya Lotfi and Bungau Simona},
title = {Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets},
journal = {Revista de Chimie},
volume = {71},
number = {2},
pages = {22-29},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.2.7886},
url = {https://revistadechimie.ro/Articles.asp?ID=7886}
}

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