First Quarter Screening for Aneuploidy

Osvar, Florina Nela; Ratiu, Adrian; Voita-Mekeres, Florica; Mekeres, Gabriel Mihai; Voita, Florin Gheorghe; Abu-Awwad, Ahmed; Bembea, Marius

Florina Nela Osvar, Adrian Ratiu, Florica Voita-Mekeres, Gabriel Mihai Mekeres, Florin Gheorghe Voita, Ahmed Abu-Awwad, Marius Bembea

First Quarter Screening for Aneuploidy

Abstract:

The objective of this paper is to evaluate the rate of detection of chromosomal abnormalities through the non-invasive prenatal test (NIPT) and its contribution to reducing the number of invasive tests. We conducted a prospective study on a batch of 3,000 single-pregnancy pregnancies highlighted in the first trimester. The patients were divided into two study groups, the first group, which we will call the TPNI (Non-Invasive Prenatal Test) group. First trimester screening was performed by non-invasive prenatal test at 10 weeks, and ultrasound between 11-13 +/- 6 days according to the criteria of the Fetal Medicine Foundation (FMF. London, UK). The sensitivity, specificity and accuracy of the two screening methods are almost similar, using NITP screening we obtain a rate of approximately 20% lower false-positive results, and we also perform a smaller number of invasive tests.

Keywords:
aneuploidy; combined screening; non-invasive prenatal test

Issue: 2020, Volume 71, Issue 1

Pages: 313-319

Publication date: 2020/2/7

https://doi.org/10.37358/RC.20.1.7851

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
OSVAR, F.N., RATIU, A., VOITA-MEKERES, F., MEKERES, G.M., VOITA, F.G., ABU-AWWAD, A., BEMBEA, M., First Quarter Screening for Aneuploidy, Rev. Chim., 71(1), 2020, 313-319.

Vancouver
Osvar FN, Ratiu A, Voita-Mekeres F, Mekeres GM, Voita FG, Abu-Awwad A, Bembea M. First Quarter Screening for Aneuploidy. Rev. Chim.[internet]. 2020 Jan;71(1):313-319. Available from: https://doi.org/10.37358/RC.20.1.7851

APA 6th edition
Osvar, F.N., Ratiu, A., Voita-Mekeres, F., Mekeres, G.M., Voita, F.G., Abu-Awwad, A. & Bembea, M. (2020). First Quarter Screening for Aneuploidy. Revista de Chimie, 71(1), 313-319. https://doi.org/10.37358/RC.20.1.7851

Harvard
Osvar, F.N., Ratiu, A., Voita-Mekeres, F., Mekeres, G.M., Voita, F.G., Abu-Awwad, A., Bembea, M. (2020). 'First Quarter Screening for Aneuploidy', Revista de Chimie, 71(1), pp. 313-319. https://doi.org/10.37358/RC.20.1.7851

IEEE
F.N. Osvar, A. Ratiu, F. Voita-Mekeres, G.M. Mekeres, F.G. Voita, A. Abu-Awwad, M. Bembea, "First Quarter Screening for Aneuploidy". Revista de Chimie, vol. 71, no. 1, pp. 313-319, 2020. [online]. https://doi.org/10.37358/RC.20.1.7851

Text
Florina Nela Osvar, Adrian Ratiu, Florica Voita-Mekeres, Gabriel Mihai Mekeres, Florin Gheorghe Voita, Ahmed Abu-Awwad, Marius Bembea,
First Quarter Screening for Aneuploidy,
Revista de Chimie,
Volume 71, Issue 1,
2020,
Pages 313-319,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.1.7851.
(https://revistadechimie.ro/Articles.asp?ID=7851)
Keywords: aneuploidy; combined screening; non-invasive prenatal test

RIS
TY - JOUR
T1 - First Quarter Screening for Aneuploidy
A1 - Osvar, Florina Nela
A2 - Ratiu, Adrian
A3 - Voita-Mekeres, Florica
A4 - Mekeres, Gabriel Mihai
A5 - Voita, Florin Gheorghe
A6 - Abu-Awwad, Ahmed
A7 - Bembea, Marius
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 1
SP - 313
EP - 319
UR - https://doi.org/10.37358/RC.20.1.7851
KW - aneuploidy
KW - combined screening
KW - non-invasive prenatal test
ER -

BibTex
@article{RevCh2020P313,
author = {Osvar Florina Nela and Ratiu Adrian and Voita-Mekeres Florica and Mekeres Gabriel Mihai and Voita Florin Gheorghe and Abu-Awwad Ahmed and Bembea Marius},
title = {First Quarter Screening for Aneuploidy},
journal = {Revista de Chimie},
volume = {71},
number = {1},
pages = {313-319},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.1.7851},
url = {https://revistadechimie.ro/Articles.asp?ID=7851}
}

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