The Influence of the Structure of Several New ortho-Hydroxy-Ketone Derived bis-Schiff Bases on Their Antibacterial and Anti-Inflammatory Activity

Tantaru, Gladiola; Apostu, Mihai; Ghiciuc, Cristina Mihaela; Poiata, Antonia; Stefanache, Alina; Vieriu, Madalina

Gladiola Tantaru, Mihai Apostu, Cristina Mihaela Ghiciuc, Antonia Poiata, Alina Stefanache, Madalina Vieriu

The Influence of the Structure of Several New ortho-Hydroxy-Ketone Derived bis-Schiff Bases on Their Antibacterial and Anti-Inflammatory Activity

Abstract:

The article presents some bis-Schiff bases - halogenated derivatives of ortho-hydroxy-ketones - with great potential for antimicrobial and antiinflammatory activity. The antimicrobial activities of the Schiff bases were tested in comparison with Chloramphenicol, Nystatin, and Ampicillin upon the following strains: Staphylococcus aureus (ATCC 25923), Sarcina lutea (ATCC 9341), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans (ATCC 1023), Candida glabrata, two Staphylococcus aureus strains, and several clinical isolates (Proteus mirabilis, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae). Those compounds were found to be active against Gram-positive or Gram-negative bacteria, and had an anti-inflammatory effect comparable to that of Indomethacin.

Keywords:
Bis-Schiff base; anti-inflammatory effect; antimicrobial effect; experimental pharmacology

Issue: 2020, Volume 71, Issue 1

Pages: 244-248

Publication date: 2020/2/7

https://doi.org/10.37358/RC.20.1.7840

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TANTARU, G., APOSTU, M., GHICIUC, C.M., POIATA, A., STEFANACHE, A., VIERIU, M., The Influence of the Structure of Several New ortho-Hydroxy-Ketone Derived bis-Schiff Bases on Their Antibacterial and Anti-Inflammatory Activity, Rev. Chim., 71(1), 2020, 244-248.

Vancouver
Tantaru G, Apostu M, Ghiciuc CM, Poiata A, Stefanache A, Vieriu M. The Influence of the Structure of Several New ortho-Hydroxy-Ketone Derived bis-Schiff Bases on Their Antibacterial and Anti-Inflammatory Activity. Rev. Chim.[internet]. 2020 Jan;71(1):244-248. Available from: https://doi.org/10.37358/RC.20.1.7840

APA 6th edition
Tantaru, G., Apostu, M., Ghiciuc, C.M., Poiata, A., Stefanache, A. & Vieriu, M. (2020). The Influence of the Structure of Several New ortho-Hydroxy-Ketone Derived bis-Schiff Bases on Their Antibacterial and Anti-Inflammatory Activity. Revista de Chimie, 71(1), 244-248. https://doi.org/10.37358/RC.20.1.7840

Harvard
Tantaru, G., Apostu, M., Ghiciuc, C.M., Poiata, A., Stefanache, A., Vieriu, M. (2020). 'The Influence of the Structure of Several New ortho-Hydroxy-Ketone Derived bis-Schiff Bases on Their Antibacterial and Anti-Inflammatory Activity', Revista de Chimie, 71(1), pp. 244-248. https://doi.org/10.37358/RC.20.1.7840

IEEE
G. Tantaru, M. Apostu, C.M. Ghiciuc, A. Poiata, A. Stefanache, M. Vieriu, "The Influence of the Structure of Several New ortho-Hydroxy-Ketone Derived bis-Schiff Bases on Their Antibacterial and Anti-Inflammatory Activity". Revista de Chimie, vol. 71, no. 1, pp. 244-248, 2020. [online]. https://doi.org/10.37358/RC.20.1.7840

Text
Gladiola Tantaru, Mihai Apostu, Cristina Mihaela Ghiciuc, Antonia Poiata, Alina Stefanache, Madalina Vieriu,
The Influence of the Structure of Several New ortho-Hydroxy-Ketone Derived bis-Schiff Bases on Their Antibacterial and Anti-Inflammatory Activity,
Revista de Chimie,
Volume 71, Issue 1,
2020,
Pages 244-248,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.1.7840.
(https://revistadechimie.ro/Articles.asp?ID=7840)
Keywords: Bis-Schiff base; anti-inflammatory effect; antimicrobial effect; experimental pharmacology

RIS
TY - JOUR
T1 - The Influence of the Structure of Several New ortho-Hydroxy-Ketone Derived bis-Schiff Bases on Their Antibacterial and Anti-Inflammatory Activity
A1 - Tantaru, Gladiola
A2 - Apostu, Mihai
A3 - Ghiciuc, Cristina Mihaela
A4 - Poiata, Antonia
A5 - Stefanache, Alina
A6 - Vieriu, Madalina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 1
SP - 244
EP - 248
UR - https://doi.org/10.37358/RC.20.1.7840
KW - Bis-Schiff base
KW - anti-inflammatory effect
KW - antimicrobial effect
KW - experimental pharmacology
ER -

BibTex
@article{RevCh2020P244,
author = {Tantaru Gladiola and Apostu Mihai and Ghiciuc Cristina Mihaela and Poiata Antonia and Stefanache Alina and Vieriu Madalina},
title = {The Influence of the Structure of Several New ortho-Hydroxy-Ketone Derived bis-Schiff Bases on Their Antibacterial and Anti-Inflammatory Activity},
journal = {Revista de Chimie},
volume = {71},
number = {1},
pages = {244-248},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.1.7840},
url = {https://revistadechimie.ro/Articles.asp?ID=7840}
}

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