Perspectives of Silicone Elastomere Implants Use in Preventing Postoperative Complications in Pelvic Exenteration for Advanced Cancers

Jinescu, George; Bacalbasa, Nicolae; Evtodiev, Andra; Marin, Iulia-Adelina; Chiulan, Ioana; Radu, Elena-Ruxandra; Frone, Adriana Nicoleta; Costea, Ruxandra; Raita, Stefania

George Jinescu, Nicolae Bacalbasa, Andra Evtodiev, Iulia-Adelina Marin, Ioana Chiulan, Elena-Ruxandra Radu, Adriana Nicoleta Frone, Ruxandra Costea, Stefania Raita

Perspectives of Silicone Elastomere Implants Use in Preventing Postoperative Complications in Pelvic Exenteration for Advanced Cancers

Abstract:

In this work, silicone elastomer films with potential to be used as implantable pelvic prosthesis were prepared and their bioactivity was studied both in vitro and in vivo environment. Tensile tests, hardness measurement and compression analysis revealed no significant decrease of the mechanical performance after in vitro hydrolytic degradation in simulated body fluids. The in vivo biocompatibility of films was assessed by implanting them subcutaneously in swine model, for 30 days. Their mechanical characteristics were similar to those of samples immersed in simulated body fluids, for the same time interval. No sign of fibrosis or necrosis were detected from the histological analysis performed on the tissue surrounding the films. In combination, these results indicate that this material has a very good resistance to mechanical and chemical fatigue, do not release any toxic degradation products and, therefore, has great potential as to be used further for preparation of pelvic prosthesis.

Keywords:
pelvic exenteration; silicone elastomer; biocompatibility; in vivo; intestinal obstruction

Issue: 2020, Volume 71, Issue 1

Pages: 45-50

Publication date: 2020/2/7

https://doi.org/10.37358/RC.20.1.7809

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
JINESCU, G., BACALBASA, N., EVTODIEV, A., MARIN, I., CHIULAN, I., RADU, E., FRONE, A.N., COSTEA, R., RAITA, S., Perspectives of Silicone Elastomere Implants Use in Preventing Postoperative Complications in Pelvic Exenteration for Advanced Cancers, Rev. Chim., 71(1), 2020, 45-50.

Vancouver
Jinescu G, Bacalbasa N, Evtodiev A, Marin I, Chiulan I, Radu E, Frone AN, Costea R, Raita S. Perspectives of Silicone Elastomere Implants Use in Preventing Postoperative Complications in Pelvic Exenteration for Advanced Cancers. Rev. Chim.[internet]. 2020 Jan;71(1):45-50. Available from: https://doi.org/10.37358/RC.20.1.7809

APA 6th edition
Jinescu, G., Bacalbasa, N., Evtodiev, A., Marin, I., Chiulan, I., Radu, E.,... Raita, S. (2020). Perspectives of Silicone Elastomere Implants Use in Preventing Postoperative Complications in Pelvic Exenteration for Advanced Cancers. Revista de Chimie, 71(1), 45-50. https://doi.org/10.37358/RC.20.1.7809

Harvard
Jinescu, G., Bacalbasa, N., Evtodiev, A., Marin, I., Chiulan, I., Radu, E., Frone, A.N., Costea, R., Raita, S. (2020). 'Perspectives of Silicone Elastomere Implants Use in Preventing Postoperative Complications in Pelvic Exenteration for Advanced Cancers', Revista de Chimie, 71(1), pp. 45-50. https://doi.org/10.37358/RC.20.1.7809

IEEE
G. Jinescu, N. Bacalbasa, A. Evtodiev, I. Marin, I. Chiulan, E. Radu, A.N. Frone, R. Costea, S. Raita, "Perspectives of Silicone Elastomere Implants Use in Preventing Postoperative Complications in Pelvic Exenteration for Advanced Cancers". Revista de Chimie, vol. 71, no. 1, pp. 45-50, 2020. [online]. https://doi.org/10.37358/RC.20.1.7809

Text
George Jinescu, Nicolae Bacalbasa, Andra Evtodiev, Iulia-Adelina Marin, Ioana Chiulan, Elena-Ruxandra Radu, Adriana Nicoleta Frone, Ruxandra Costea, Stefania Raita,
Perspectives of Silicone Elastomere Implants Use in Preventing Postoperative Complications in Pelvic Exenteration for Advanced Cancers,
Revista de Chimie,
Volume 71, Issue 1,
2020,
Pages 45-50,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.1.7809.
(https://revistadechimie.ro/Articles.asp?ID=7809)
Keywords: pelvic exenteration; silicone elastomer; biocompatibility; in vivo; intestinal obstruction

RIS
TY - JOUR
T1 - Perspectives of Silicone Elastomere Implants Use in Preventing Postoperative Complications in Pelvic Exenteration for Advanced Cancers
A1 - Jinescu, George
A2 - Bacalbasa, Nicolae
A3 - Evtodiev, Andra
A4 - Marin, Iulia-Adelina
A5 - Chiulan, Ioana
A6 - Radu, Elena-Ruxandra
A7 - Frone, Adriana Nicoleta
A8 - Costea, Ruxandra
A9 - Raita, Stefania
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 1
SP - 45
EP - 50
UR - https://doi.org/10.37358/RC.20.1.7809
KW - pelvic exenteration
KW - silicone elastomer
KW - biocompatibility
KW - in vivo
KW - intestinal obstruction
ER -

BibTex
@article{RevCh2020P45,
author = {Jinescu George and Bacalbasa Nicolae and Evtodiev Andra and Marin Iulia-Adelina and Chiulan Ioana and Radu Elena-Ruxandra and Frone Adriana Nicoleta and Costea Ruxandra and Raita Stefania},
title = {Perspectives of Silicone Elastomere Implants Use in Preventing Postoperative Complications in Pelvic Exenteration for Advanced Cancers},
journal = {Revista de Chimie},
volume = {71},
number = {1},
pages = {45-50},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.1.7809},
url = {https://revistadechimie.ro/Articles.asp?ID=7809}
}

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