Experimental Study on Biochemical Markers of Mandibular Bone Tissue Metabolism in Rats following the Implantation of PAW-1 and Geistlich Bio-OSS Collagen

Chetrus, Viorica; Sarbu, Dumitru; Gorea, Corneliu; Chetrus, Iulian

Viorica Chetrus, Dumitru Sarbu, Corneliu Gorea, Iulian Chetrus

Experimental Study on Biochemical Markers of Mandibular Bone Tissue Metabolism in Rats following the Implantation of PAW-1 and Geistlich Bio-OSS Collagen

Abstract:

The study is based on the analysis of experimental results and determination of the bone metabolism markers by histochemical and biochemical methods performed on animals. The animals were implanted biovitroceramics PAW-1 in the mandible in the form of spongy matrix composed of fluorhydroxyapatite and microcrystallized wollastonite in a glass matrix, elaborated by the company PONETI (Romania) and Geistlich Bio-Oss-Collagen in the form of block (a mixture of granules, 0.25-1mm in size) and 10% fibers of porcine collagen. Geistlich Bio-Oss Collagen is a natural mineral bone of bovine origin, comparable both chemically and structurally to the mineralized human bone. It has a spongy consistency that allows simple modeling, and collagen facilitates the adaptation of the material on the defect site.The biochemical blood analysis showed an increased activity of bone thermolabile alkaline phosphatase over 30 days, the maximum being reached over 60 days + 20% (p[0.05) from the beginning of the experiment. The activity of tartrate-resistant bone acid phosphatase, on the contrary, decreased veridically by 22% over 60 days after implantation. Over 30 days after the beginning of the experiment under the action of the implanted material, the level of average molecules (AM) increased by 35% (p [0.05), while nucleotide substances (NS) increased by 51% (p [0.05). Within 60 days after implantation, the values of these indices showed a decreasing tendency. The fact mentioned above denotes that their osteoregenerative action increases under the influence of implanted materials.

Keywords:
Thermolabile alkaline phosphatase; tartrate-resistant acid phosphatase; average molecules; nucleotide substances

Issue: 2019, Volume 70, Issue 9

Pages: 3416-3418

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7561

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Citation Styles

Cite this article as:
CHETRUS, V., SARBU, D., GOREA, C., CHETRUS, I., Experimental Study on Biochemical Markers of Mandibular Bone Tissue Metabolism in Rats following the Implantation of PAW-1 and Geistlich Bio-OSS Collagen, Rev. Chim., 70(9), 2019, 3416-3418.

Vancouver
Chetrus V, Sarbu D, Gorea C, Chetrus I. Experimental Study on Biochemical Markers of Mandibular Bone Tissue Metabolism in Rats following the Implantation of PAW-1 and Geistlich Bio-OSS Collagen. Rev. Chim.[internet]. 2019 Sep;70(9):3416-3418. Available from: https://doi.org/10.37358/RC.19.9.7561

APA 6th edition
Chetrus, V., Sarbu, D., Gorea, C. & Chetrus, I. (2019). Experimental Study on Biochemical Markers of Mandibular Bone Tissue Metabolism in Rats following the Implantation of PAW-1 and Geistlich Bio-OSS Collagen. Revista de Chimie, 70(9), 3416-3418. https://doi.org/10.37358/RC.19.9.7561

Harvard
Chetrus, V., Sarbu, D., Gorea, C., Chetrus, I. (2019). 'Experimental Study on Biochemical Markers of Mandibular Bone Tissue Metabolism in Rats following the Implantation of PAW-1 and Geistlich Bio-OSS Collagen', Revista de Chimie, 70(9), pp. 3416-3418. https://doi.org/10.37358/RC.19.9.7561

IEEE
V. Chetrus, D. Sarbu, C. Gorea, I. Chetrus, "Experimental Study on Biochemical Markers of Mandibular Bone Tissue Metabolism in Rats following the Implantation of PAW-1 and Geistlich Bio-OSS Collagen". Revista de Chimie, vol. 70, no. 9, pp. 3416-3418, 2019. [online]. https://doi.org/10.37358/RC.19.9.7561

Text
Viorica Chetrus, Dumitru Sarbu, Corneliu Gorea, Iulian Chetrus,
Experimental Study on Biochemical Markers of Mandibular Bone Tissue Metabolism in Rats following the Implantation of PAW-1 and Geistlich Bio-OSS Collagen,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3416-3418,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7561.
(https://revistadechimie.ro/Articles.asp?ID=7561)
Keywords: Thermolabile alkaline phosphatase; tartrate-resistant acid phosphatase; average molecules; nucleotide substances

RIS
TY - JOUR
T1 - Experimental Study on Biochemical Markers of Mandibular Bone Tissue Metabolism in Rats following the Implantation of PAW-1 and Geistlich Bio-OSS Collagen
A1 - Chetrus, Viorica
A2 - Sarbu, Dumitru
A3 - Gorea, Corneliu
A4 - Chetrus, Iulian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3416
EP - 3418
UR - https://doi.org/10.37358/RC.19.9.7561
KW - Thermolabile alkaline phosphatase
KW - tartrate-resistant acid phosphatase
KW - average molecules
KW - nucleotide substances
ER -

BibTex
@article{RevCh2019P3416,
author = {Chetrus Viorica and Sarbu Dumitru and Gorea Corneliu and Chetrus Iulian},
title = {Experimental Study on Biochemical Markers of Mandibular Bone Tissue Metabolism in Rats following the Implantation of PAW-1 and Geistlich Bio-OSS Collagen},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3416-3418},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7561},
url = {https://revistadechimie.ro/Articles.asp?ID=7561}
}

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