Evaluation of the Biocompatibility and Graft Integration Following Ligamentoplasty or Augmentation. Experimental study on rabbits

Chitea, Claudiu; Tomoaia, Gheorghe; Toader, Oana D.; Milea, Claudia; Trante, Octavian; Earar, Kamel; Saceleanu, Vicentiu

Claudiu Chitea, Gheorghe Tomoaia, Oana D. Toader, Claudia Milea, Octavian Trante, Kamel Earar, Vicentiu Saceleanu

Evaluation of the Biocompatibility and Graft Integration Following Ligamentoplasty or Augmentation. Experimental study on rabbits

Abstract:

Several techniques are used to reconstruct the anterior cruciate ligaments (ACL) by using different grafts in order to obtain a new ligament with properties closest to those of the healthy one. Our aim was a faster graft harvesting and the integration into the bone tissue; we have studied the efficiency of the techniques that preserve the torn ligament end vs. the techniques that used a graft harvested from the patient. The ligamentoplasty studies performed on rabbits reveal a satisfactorily cost-efficiency ratio, this being the main reason for choosing this model. We wanted to study the importance of preserving one edge of the torn ligament as a base of integration for the new graft and compare the appearance of the blood vessels and the neoformation tissue in the two study groups. For the first study group we performed an implantation technique that uses a complete new graft harvested from the same animal and for the second group we used the technique which preserves the torn ligament. All the surgical procedures were conducted on the NZW rabbits. All ligamentoplasty reconstruction surgical interventions were conducted on the left limb and the graft was harvested from the extensori digitorum longi located on the lateral side of the rabbit’s thigh. Twelve rabbits in each group were operated upon using the two techniques and the results were compared. No major complications were noted, the long term results were similar, and with no significant differences as far as the ligament integration was concerned. The study group in which the ligament end was preserved showed a more rapid integration. Our study suggests that keeping a longer ligament end correlates with early graft integration.

Keywords:
graft; ligamentoplasty; biocompatibility; rabbit; suture; polydioxanone

Issue: 2019, Volume 70, Issue 4

Pages: 1460-1465

Publication date: 2019/5/15

https://doi.org/10.37358/RC.19.4.7149

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CHITEA, C., TOMOAIA, G., TOADER, O.D., MILEA, C., TRANTE, O., EARAR, K., SACELEANU, V., Evaluation of the Biocompatibility and Graft Integration Following Ligamentoplasty or Augmentation. Experimental study on rabbits, Rev. Chim., 70(4), 2019, 1460-1465.

Vancouver
Chitea C, Tomoaia G, Toader OD, Milea C, Trante O, Earar K, Saceleanu V. Evaluation of the Biocompatibility and Graft Integration Following Ligamentoplasty or Augmentation. Experimental study on rabbits. Rev. Chim.[internet]. 2019 Apr;70(4):1460-1465. Available from: https://doi.org/10.37358/RC.19.4.7149

APA 6th edition
Chitea, C., Tomoaia, G., Toader, O.D., Milea, C., Trante, O., Earar, K. & Saceleanu, V. (2019). Evaluation of the Biocompatibility and Graft Integration Following Ligamentoplasty or Augmentation. Experimental study on rabbits. Revista de Chimie, 70(4), 1460-1465. https://doi.org/10.37358/RC.19.4.7149

Harvard
Chitea, C., Tomoaia, G., Toader, O.D., Milea, C., Trante, O., Earar, K., Saceleanu, V. (2019). 'Evaluation of the Biocompatibility and Graft Integration Following Ligamentoplasty or Augmentation. Experimental study on rabbits', Revista de Chimie, 70(4), pp. 1460-1465. https://doi.org/10.37358/RC.19.4.7149

IEEE
C. Chitea, G. Tomoaia, O.D. Toader, C. Milea, O. Trante, K. Earar, V. Saceleanu, "Evaluation of the Biocompatibility and Graft Integration Following Ligamentoplasty or Augmentation. Experimental study on rabbits". Revista de Chimie, vol. 70, no. 4, pp. 1460-1465, 2019. [online]. https://doi.org/10.37358/RC.19.4.7149

Text
Claudiu Chitea, Gheorghe Tomoaia, Oana D. Toader, Claudia Milea, Octavian Trante, Kamel Earar, Vicentiu Saceleanu,
Evaluation of the Biocompatibility and Graft Integration Following Ligamentoplasty or Augmentation. Experimental study on rabbits,
Revista de Chimie,
Volume 70, Issue 4,
2019,
Pages 1460-1465,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.4.7149.
(https://revistadechimie.ro/Articles.asp?ID=7149)
Keywords: graft; ligamentoplasty; biocompatibility; rabbit; suture; polydioxanone

RIS
TY - JOUR
T1 - Evaluation of the Biocompatibility and Graft Integration Following Ligamentoplasty or Augmentation. Experimental study on rabbits
A1 - Chitea, Claudiu
A2 - Tomoaia, Gheorghe
A3 - Toader, Oana D.
A4 - Milea, Claudia
A5 - Trante, Octavian
A6 - Earar, Kamel
A7 - Saceleanu, Vicentiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 4
SP - 1460
EP - 1465
UR - https://doi.org/10.37358/RC.19.4.7149
KW - graft
KW - ligamentoplasty
KW - biocompatibility
KW - rabbit
KW - suture
KW - polydioxanone
ER -

BibTex
@article{RevCh2019P1460,
author = {Chitea Claudiu and Tomoaia Gheorghe and Toader Oana D. and Milea Claudia and Trante Octavian and Earar Kamel and Saceleanu Vicentiu},
title = {Evaluation of the Biocompatibility and Graft Integration Following Ligamentoplasty or Augmentation. Experimental study on rabbits},
journal = {Revista de Chimie},
volume = {70},
number = {4},
pages = {1460-1465},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.4.7149},
url = {https://revistadechimie.ro/Articles.asp?ID=7149}
}

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