The Role of Anticoagulant Therapy in the Prevention of Preeclampsia Pharmacokinetic and pharmacodynamic mechanisms

Turcan, Natalia; Bohiltea, Roxana; Neacsu, Adrian; Baros, Alexandru; Cirstoiu, Monica Mihaela

Natalia Turcan, Roxana Bohiltea, Adrian Neacsu, Alexandru Baros, Monica Mihaela Cirstoiu

The Role of Anticoagulant Therapy in the Prevention of Preeclampsia Pharmacokinetic and pharmacodynamic mechanisms

Abstract:

Pregnancies complicated with preeclampsia associate a high incidence of intrauterine fetal death, intrauterine growth restriction, premature ruptures of membranes, abruption placentae and prematurity. Understanding the pathogenesis of preeclampsia is mandatory for a correct approach and prevention management of high risk cases. Placental hypoperfusion seems to be a key factor in developing systemic resounding. By placental necrosis and apoptosis, cell-free DNA is released in maternal circulation in early pregnancy, respectively prior 17 weeks of gestation. There is no test, useful in early pregnancy, accurate enough to predict preeclampsia. Various screening test have been proposed in order to predict the development of preeclampsia, but most of them are not sufficiently accurate for general screening. There is a continuous debate regarding the algorithm of administration, doses and timing of low dose aspirin. The initiation moment is crucial, as the administration after the development symptoms and signs of preeclampsia do not interfere with the progression and the severity of the disease. Early initiation of therapy with low dose aspirin, prior the end of the first trimester is important since the pathogenesis mechanisms of preeclampsia take place in the first trimester. The action of acetylsalicylic acid consists in inhibition of COX-1 and COX-2 (cyclooxygenase isoenzymes), necessary for prostaglandin biosynthesis. Preferential inhibition of Thromboxane A2 by low dose aspirin, counterbalance the increased production of thromboxanes characteristic to preeclampsia and modulate the inflammatory process, amplified in pregnant women with preeclampsia.

Keywords:
preeclampsia; prevention; aspirin

Issue: 2019, Volume 70, Issue 4

Pages: 1424-1428

Publication date: 2019/5/15

https://doi.org/10.37358/RC.19.4.7142

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
TURCAN, N., BOHILTEA, R., NEACSU, A., BAROS, A., CIRSTOIU, M.M., The Role of Anticoagulant Therapy in the Prevention of Preeclampsia Pharmacokinetic and pharmacodynamic mechanisms, Rev. Chim., 70(4), 2019, 1424-1428.

Vancouver
Turcan N, Bohiltea R, Neacsu A, Baros A, Cirstoiu MM. The Role of Anticoagulant Therapy in the Prevention of Preeclampsia Pharmacokinetic and pharmacodynamic mechanisms. Rev. Chim.[internet]. 2019 Apr;70(4):1424-1428. Available from: https://doi.org/10.37358/RC.19.4.7142

APA 6th edition
Turcan, N., Bohiltea, R., Neacsu, A., Baros, A. & Cirstoiu, M.M. (2019). The Role of Anticoagulant Therapy in the Prevention of Preeclampsia Pharmacokinetic and pharmacodynamic mechanisms. Revista de Chimie, 70(4), 1424-1428. https://doi.org/10.37358/RC.19.4.7142

Harvard
Turcan, N., Bohiltea, R., Neacsu, A., Baros, A., Cirstoiu, M.M. (2019). 'The Role of Anticoagulant Therapy in the Prevention of Preeclampsia Pharmacokinetic and pharmacodynamic mechanisms', Revista de Chimie, 70(4), pp. 1424-1428. https://doi.org/10.37358/RC.19.4.7142

IEEE
N. Turcan, R. Bohiltea, A. Neacsu, A. Baros, M.M. Cirstoiu, "The Role of Anticoagulant Therapy in the Prevention of Preeclampsia Pharmacokinetic and pharmacodynamic mechanisms". Revista de Chimie, vol. 70, no. 4, pp. 1424-1428, 2019. [online]. https://doi.org/10.37358/RC.19.4.7142

Text
Natalia Turcan, Roxana Bohiltea, Adrian Neacsu, Alexandru Baros, Monica Mihaela Cirstoiu,
The Role of Anticoagulant Therapy in the Prevention of Preeclampsia Pharmacokinetic and pharmacodynamic mechanisms,
Revista de Chimie,
Volume 70, Issue 4,
2019,
Pages 1424-1428,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.4.7142.
(https://revistadechimie.ro/Articles.asp?ID=7142)
Keywords: preeclampsia; prevention; aspirin

RIS
TY - JOUR
T1 - The Role of Anticoagulant Therapy in the Prevention of Preeclampsia Pharmacokinetic and pharmacodynamic mechanisms
A1 - Turcan, Natalia
A2 - Bohiltea, Roxana
A3 - Neacsu, Adrian
A4 - Baros, Alexandru
A5 - Cirstoiu, Monica Mihaela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 4
SP - 1424
EP - 1428
UR - https://doi.org/10.37358/RC.19.4.7142
KW - preeclampsia
KW - prevention
KW - aspirin
ER -

BibTex
@article{RevCh2019P1424,
author = {Turcan Natalia and Bohiltea Roxana and Neacsu Adrian and Baros Alexandru and Cirstoiu Monica Mihaela},
title = {The Role of Anticoagulant Therapy in the Prevention of Preeclampsia Pharmacokinetic and pharmacodynamic mechanisms},
journal = {Revista de Chimie},
volume = {70},
number = {4},
pages = {1424-1428},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.4.7142},
url = {https://revistadechimie.ro/Articles.asp?ID=7142}
}

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