The Influence of Nitric Oxid Donors Nebivolol and S-Nitrosoglutathion of the Oxidatives Stress and Liver Function in Rats

Buca, Beatrice Rozalina; Mititelu-Tartau, Liliana; Filip, Cristiana; Filip, Nina; Rezus, Ciprian; Iancu, Cristina; Rezus, Elena; Pinzariu, Alin Constantin; Pasca, Sorin Aurelian; Lupusoru, Catalina Elena; Lupusoru, Raoul Vasile

Beatrice Rozalina Buca, Liliana Mititelu-Tartau, Cristiana Filip, Nina Filip, Ciprian Rezus, Cristina Iancu, Elena Rezus, Alin Constantin Pinzariu, Sorin Aurelian Pasca, Catalina Elena Lupusoru, Raoul Vasile Lupusoru

The Influence of Nitric Oxid Donors Nebivolol and S-Nitrosoglutathion of the Oxidatives Stress and Liver Function in Rats

Abstract:

We aimed to investigate the influence of two nitric oxide donors on the oxidative stress and the liver function in rats with experimental-induced acute paw inflammation.The experiment was carried out on white male Wistar rats (200-250 g), randomly assigned into 4 groups of 5 animals each, which received the substances intraperitoneal, as follows: group 1 (Control) saline solution 0.1 ml/100 g body weight; group 2 (IND) indomethacin 150 mg/kg body weight (kbw); groups 3 (NEB) and 4 (GSNO) nebivolol 1 mg/kbw, respectively S-nitroso-glutathione 1 mg/kbw. Carrageenan-induced rat‘s paw edema test was used for the generation of acute inflammation. The activity of liver enzymes and of some antioxidant parameters was evaluated before the carrageenan injection, after 24 hours and 3 days. The experimental protocol was approved by the University‘s Ethic Committee on Research and Ethical Issues.The administration of indomethacin, nebivolol and S-nitroso-glutathione appears to decrease the oxidative stress after 24 h in rats with experimental-induced acute paw inflammation. The nitric oxide donors nebivolol and S-nitroso-glutathione produced moderate functional and structural liver disturbances in rats with acute inflammation.

Keywords:
Nebivolol; S-nitrosoglutathione; liver; oxidative stress; rats

Issue: 2019, Volume 70, Issue 4

Pages: 1360-1363

Publication date: 2019/5/15

https://doi.org/10.37358/RC.19.4.7127

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BUCA, B.R., MITITELU-TARTAU, L., FILIP, C., FILIP, N., REZUS, C., IANCU, C., REZUS, E., PINZARIU, A.C., PASCA, S.A., LUPUSORU, C.E., LUPUSORU, R.V., The Influence of Nitric Oxid Donors Nebivolol and S-Nitrosoglutathion of the Oxidatives Stress and Liver Function in Rats, Rev. Chim., 70(4), 2019, 1360-1363.

Vancouver
Buca BR, Mititelu-Tartau L, Filip C, Filip N, Rezus C, Iancu C, Rezus E, Pinzariu AC, Pasca SA, Lupusoru CE, Lupusoru RV. The Influence of Nitric Oxid Donors Nebivolol and S-Nitrosoglutathion of the Oxidatives Stress and Liver Function in Rats. Rev. Chim.[internet]. 2019 Apr;70(4):1360-1363. Available from: https://doi.org/10.37358/RC.19.4.7127

APA 6th edition
Buca, B.R., Mititelu-Tartau, L., Filip, C., Filip, N., Rezus, C., Iancu, C.,... Lupusoru, R.V. (2019). The Influence of Nitric Oxid Donors Nebivolol and S-Nitrosoglutathion of the Oxidatives Stress and Liver Function in Rats. Revista de Chimie, 70(4), 1360-1363. https://doi.org/10.37358/RC.19.4.7127

Harvard
Buca, B.R., Mititelu-Tartau, L., Filip, C., Filip, N., Rezus, C., Iancu, C., Rezus, E., Pinzariu, A.C., Pasca, S.A., Lupusoru, C.E., Lupusoru, R.V. (2019). 'The Influence of Nitric Oxid Donors Nebivolol and S-Nitrosoglutathion of the Oxidatives Stress and Liver Function in Rats', Revista de Chimie, 70(4), pp. 1360-1363. https://doi.org/10.37358/RC.19.4.7127

IEEE
B.R. Buca, L. Mititelu-Tartau, C. Filip, N. Filip, C. Rezus, C. Iancu, E. Rezus, A.C. Pinzariu, S.A. Pasca, C.E. Lupusoru, R.V. Lupusoru, "The Influence of Nitric Oxid Donors Nebivolol and S-Nitrosoglutathion of the Oxidatives Stress and Liver Function in Rats". Revista de Chimie, vol. 70, no. 4, pp. 1360-1363, 2019. [online]. https://doi.org/10.37358/RC.19.4.7127

Text
Beatrice Rozalina Buca, Liliana Mititelu-Tartau, Cristiana Filip, Nina Filip, Ciprian Rezus, Cristina Iancu, Elena Rezus, Alin Constantin Pinzariu, Sorin Aurelian Pasca, Catalina Elena Lupusoru, Raoul Vasile Lupusoru,
The Influence of Nitric Oxid Donors Nebivolol and S-Nitrosoglutathion of the Oxidatives Stress and Liver Function in Rats,
Revista de Chimie,
Volume 70, Issue 4,
2019,
Pages 1360-1363,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.4.7127.
(https://revistadechimie.ro/Articles.asp?ID=7127)
Keywords: Nebivolol; S-nitrosoglutathione; liver; oxidative stress; rats

RIS
TY - JOUR
T1 - The Influence of Nitric Oxid Donors Nebivolol and S-Nitrosoglutathion of the Oxidatives Stress and Liver Function in Rats
A1 - Buca, Beatrice Rozalina
A2 - Mititelu-Tartau, Liliana
A3 - Filip, Cristiana
A4 - Filip, Nina
A5 - Rezus, Ciprian
A6 - Iancu, Cristina
A7 - Rezus, Elena
A8 - Pinzariu, Alin Constantin
A9 - Pasca, Sorin Aurelian
A10 - Lupusoru, Catalina Elena
A11 - Lupusoru, Raoul Vasile
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 4
SP - 1360
EP - 1363
UR - https://doi.org/10.37358/RC.19.4.7127
KW - Nebivolol
KW - S-nitrosoglutathione
KW - liver
KW - oxidative stress
KW - rats
ER -

BibTex
@article{RevCh2019P1360,
author = {Buca Beatrice Rozalina and Mititelu-Tartau Liliana and Filip Cristiana and Filip Nina and Rezus Ciprian and Iancu Cristina and Rezus Elena and Pinzariu Alin Constantin and Pasca Sorin Aurelian and Lupusoru Catalina Elena and Lupusoru Raoul Vasile},
title = {The Influence of Nitric Oxid Donors Nebivolol and S-Nitrosoglutathion of the Oxidatives Stress and Liver Function in Rats},
journal = {Revista de Chimie},
volume = {70},
number = {4},
pages = {1360-1363},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.4.7127},
url = {https://revistadechimie.ro/Articles.asp?ID=7127}
}

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