Comparative Study on the Psychoactive Effects of Nicotine and Cotinine

Vlasceanu, Ana Maria; Chirita, Cornel; Mihai, Dragos; Marineci, Cristina Daniela; Stan, Miriana; Balalau, Cristian; Gradinaru, Daniela; Baconi, Daniela

Ana Maria Vlasceanu, Cornel Chirita, Dragos Mihai, Cristina Daniela Marineci, Miriana Stan, Cristian Balalau, Daniela Gradinaru, Daniela Baconi

Comparative Study on the Psychoactive Effects of Nicotine and Cotinine

Abstract:

Nicotine and its main metabolite cotinine have been suggested to have psychoactive properties in humans and animals. The present study aims to investigate comparatively the psychoactive profile, as antidepressant and anxiolytic effects, of cotinine and nicotine in NMRI mice. The animalswere orally treated with nicotine (0.5mg/kg) and cotinine (5 mg/kg) for 14 days. Pharmacological tests (forced swimming test (FST) and tail suspension test (TST) for the antidepressant activity, as well as elevated maze test for the anxiolytic activity) were performed after 1, 7 and 14 days. Imipramine (25 mg/kg) was used as a control for the antidepressant activity. Imipramine and cotinine bothexerted comparable and statistically significant antidepressant effectsafter 7 days of treatment, while no effect was observedin the animals treated with nicotine. An important anxiogenic effect was revealed for imipramine after 14 days treatment. Nicotine was shown to have an axiolytic effect after 14 days treatment. The study highlighted some psychotropic effects of nicotine and cotinine in mice, depending on the treatment regimen.

Keywords:
nicotine; cotinine; antidepressant activity; anxiolytic effects

Issue: 2019, Volume 70, Issue 4

Pages: 1114-1117

Publication date: 2019/5/15

https://doi.org/10.37358/RC.19.4.7075

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
VLASCEANU, A.M., CHIRITA, C., MIHAI, D., MARINECI, C.D., STAN, M., BALALAU, C., GRADINARU, D., BACONI, D., Comparative Study on the Psychoactive Effects of Nicotine and Cotinine, Rev. Chim., 70(4), 2019, 1114-1117.

Vancouver
Vlasceanu AM, Chirita C, Mihai D, Marineci CD, Stan M, Balalau C, Gradinaru D, Baconi D. Comparative Study on the Psychoactive Effects of Nicotine and Cotinine. Rev. Chim.[internet]. 2019 Apr;70(4):1114-1117. Available from: https://doi.org/10.37358/RC.19.4.7075

APA 6th edition
Vlasceanu, A.M., Chirita, C., Mihai, D., Marineci, C.D., Stan, M., Balalau, C., Gradinaru, D. & Baconi, D. (2019). Comparative Study on the Psychoactive Effects of Nicotine and Cotinine. Revista de Chimie, 70(4), 1114-1117. https://doi.org/10.37358/RC.19.4.7075

Harvard
Vlasceanu, A.M., Chirita, C., Mihai, D., Marineci, C.D., Stan, M., Balalau, C., Gradinaru, D., Baconi, D. (2019). 'Comparative Study on the Psychoactive Effects of Nicotine and Cotinine', Revista de Chimie, 70(4), pp. 1114-1117. https://doi.org/10.37358/RC.19.4.7075

IEEE
A.M. Vlasceanu, C. Chirita, D. Mihai, C.D. Marineci, M. Stan, C. Balalau, D. Gradinaru, D. Baconi, "Comparative Study on the Psychoactive Effects of Nicotine and Cotinine". Revista de Chimie, vol. 70, no. 4, pp. 1114-1117, 2019. [online]. https://doi.org/10.37358/RC.19.4.7075

Text
Ana Maria Vlasceanu, Cornel Chirita, Dragos Mihai, Cristina Daniela Marineci, Miriana Stan, Cristian Balalau, Daniela Gradinaru, Daniela Baconi,
Comparative Study on the Psychoactive Effects of Nicotine and Cotinine,
Revista de Chimie,
Volume 70, Issue 4,
2019,
Pages 1114-1117,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.4.7075.
(https://revistadechimie.ro/Articles.asp?ID=7075)
Keywords: nicotine; cotinine; antidepressant activity; anxiolytic effects

RIS
TY - JOUR
T1 - Comparative Study on the Psychoactive Effects of Nicotine and Cotinine
A1 - Vlasceanu, Ana Maria
A2 - Chirita, Cornel
A3 - Mihai, Dragos
A4 - Marineci, Cristina Daniela
A5 - Stan, Miriana
A6 - Balalau, Cristian
A7 - Gradinaru, Daniela
A8 - Baconi, Daniela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 4
SP - 1114
EP - 1117
UR - https://doi.org/10.37358/RC.19.4.7075
KW - nicotine
KW - cotinine
KW - antidepressant activity
KW - anxiolytic effects
ER -

BibTex
@article{RevCh2019P1114,
author = {Vlasceanu Ana Maria and Chirita Cornel and Mihai Dragos and Marineci Cristina Daniela and Stan Miriana and Balalau Cristian and Gradinaru Daniela and Baconi Daniela},
title = {Comparative Study on the Psychoactive Effects of Nicotine and Cotinine},
journal = {Revista de Chimie},
volume = {70},
number = {4},
pages = {1114-1117},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.4.7075},
url = {https://revistadechimie.ro/Articles.asp?ID=7075}
}

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