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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 1, 112-117

https://doi.org/10.37358/RC.19.1.6862

Oana Alexandru, Ada Maria Georgescu, Alexandra Dragoi, Marius Eugen Ciurea, Citto Iulian Taisescu, Ligia Gabriela Tataranu, Corina Brindusa, Mihai Virgil Boldeanu, Stefana Oana Purcaru, Cristian Adrian Silosi, Alin Demetrian, Anica Dricu

In vitro Antineoplastic Activity of Dye Compounds on Human Glioblastoma Cells

Abstract:

Dyes are an important class of natural and synthetic compounds, recently studied as potential anticancer drugs. Among various natural dye molecules, Curcumin was extensively studied in treatment of malignant gliomas, a highly incurable disease. Curcumin was reported to induce cell death in malignant gliomas by induction autophagy and apoptosis. We have previously reported that Helianthin, a synthetic dye compound, also induced apoptotic cell death in high grade glioma cells. In this study we evaluated the antiproliferative and the apoptotic effect of Curcumin and Helianthin on a human low passage glioblastoma cell line. We found that both compounds displayed antiproliferative properties on glioblastoma cells, however, at equimolar concentrations, Helianthin induced more cytotoxic effect than Curcumin. IC50 value is considered a good indicator of drug efficacy. We found that Helianthin required a lower concentration to achieve IC50 (16.9.735 ±14.8 mM) than Curcumin (68.5 ±12.3 mM). We also found that Curcumin and Helianthin treatment induced caspase 3, 8 and 9 activation in glioblastoma cells. This study may lead to a widespread search for dye agents that may represent an untapped source of drugs for cancer treatment.
Keywords:
dye compounds; Curcumin; Helianthin; apoptosis; glioblastoma; therapy

Issue: 2019, Volume 70, Issue 1
Pages: 112-117
Publication date: 15/02/2019
https://doi.org/10.37358/RC.19.1.6862
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
ALEXANDRU, O., GEORGESCU, A.M., DRAGOI, A., CIUREA, M.E., TAISESCU, C.I., TATARANU, L.G., BRINDUSA, C., BOLDEANU, M.V., PURCARU, S.O., SILOSI, C.A., DEMETRIAN, A., DRICU, A., In vitro Antineoplastic Activity of Dye Compounds on Human Glioblastoma Cells, Rev. Chim., 70(1), 2019, 112-117.

Vancouver
Alexandru O, Georgescu AM, Dragoi A, Ciurea ME, Taisescu CI, Tataranu LG, Brindusa C, Boldeanu MV, Purcaru SO, Silosi CA, Demetrian A, Dricu A. In vitro Antineoplastic Activity of Dye Compounds on Human Glioblastoma Cells. Rev. Chim.[internet]. 2019 Jan;70(1):112-117. Available from: https://doi.org/10.37358/RC.19.1.6862


APA 6th edition
Alexandru, O., Georgescu, A.M., Dragoi, A., Ciurea, M.E., Taisescu, C.I., Tataranu, L.G.,... Dricu, A. (2019). In vitro Antineoplastic Activity of Dye Compounds on Human Glioblastoma Cells. Revista de Chimie, 70(1), 112-117. https://doi.org/10.37358/RC.19.1.6862


Harvard
Alexandru, O., Georgescu, A.M., Dragoi, A., Ciurea, M.E., Taisescu, C.I., Tataranu, L.G., Brindusa, C., Boldeanu, M.V., Purcaru, S.O., Silosi, C.A., Demetrian, A., Dricu, A. (2019). 'In vitro Antineoplastic Activity of Dye Compounds on Human Glioblastoma Cells', Revista de Chimie, 70(1), pp. 112-117. https://doi.org/10.37358/RC.19.1.6862


IEEE
O. Alexandru, A.M. Georgescu, A. Dragoi, M.E. Ciurea, C.I. Taisescu, L.G. Tataranu, C. Brindusa, M.V. Boldeanu, S.O. Purcaru, C.A. Silosi, A. Demetrian, A. Dricu, "In vitro Antineoplastic Activity of Dye Compounds on Human Glioblastoma Cells". Revista de Chimie, vol. 70, no. 1, pp. 112-117, 2019. [online]. https://doi.org/10.37358/RC.19.1.6862


Text
Oana Alexandru, Ada Maria Georgescu, Alexandra Dragoi, Marius Eugen Ciurea, Citto Iulian Taisescu, Ligia Gabriela Tataranu, Corina Brindusa, Mihai Virgil Boldeanu, Stefana Oana Purcaru, Cristian Adrian Silosi, Alin Demetrian, Anica Dricu,
In vitro Antineoplastic Activity of Dye Compounds on Human Glioblastoma Cells,
Revista de Chimie,
Volume 70, Issue 1,
2019,
Pages 112-117,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.1.6862.
(https://revistadechimie.ro/Articles.asp?ID=6862)
Keywords: dye compounds; Curcumin; Helianthin; apoptosis; glioblastoma; therapy


RIS
TY - JOUR
T1 - In vitro Antineoplastic Activity of Dye Compounds on Human Glioblastoma Cells
A1 - Alexandru, Oana
A2 - Georgescu, Ada Maria
A3 - Dragoi, Alexandra
A4 - Ciurea, Marius Eugen
A5 - Taisescu, Citto Iulian
A6 - Tataranu, Ligia Gabriela
A7 - Brindusa, Corina
A8 - Boldeanu, Mihai Virgil
A9 - Purcaru, Stefana Oana
A10 - Silosi, Cristian Adrian
A11 - Demetrian, Alin
A12 - Dricu, Anica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 1
SP - 112
EP - 117
UR - https://doi.org/10.37358/RC.19.1.6862
KW - dye compounds
KW - Curcumin
KW - Helianthin
KW - apoptosis
KW - glioblastoma
KW - therapy
ER -


BibTex
@article{RevCh2019P112,
author = {Alexandru Oana and Georgescu Ada Maria and Dragoi Alexandra and Ciurea Marius Eugen and Taisescu Citto Iulian and Tataranu Ligia Gabriela and Brindusa Corina and Boldeanu Mihai Virgil and Purcaru Stefana Oana and Silosi Cristian Adrian and Demetrian Alin and Dricu Anica},
title = {In vitro Antineoplastic Activity of Dye Compounds on Human Glioblastoma Cells},
journal = {Revista de Chimie},
volume = {70},
number = {1},
pages = {112-117},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.1.6862},
url = {https://revistadechimie.ro/Articles.asp?ID=6862}
}
 
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