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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 1, 78-83

https://doi.org/10.37358/RC.19.1.6855

Alexandra Totan, Daniela Gabriela Balan, Daniela Miricescu, Radu Radulescu, Iulia Ioana Stanescu, Bogdana Virgolici, Maria Mohora, Maria Greabu

Nonalcoholic Fatty Liver Disease and Vitamin E - A Promising Relationship?

Abstract:

Oxidative stress (OS) plays an important role in NAFLD molecular mechanism. Nanoencapsulation represents a novel strategy to enhance therapeutic potential of conventional drugs. Our study analyses the encapsulated vitamin E effect on lipid metabolism and oxidative stress biomarkers in NAFLD rats. Animals were divided into 3 groups : G1 - the normal diet group; G2- the high caloric diet group ; G3 - high-caloric diet group receiving PLGA-vit E, 50 mg / kg. Serum advanced human oxidative protein (AOPP), total antioxidant capacity (TAC) and vitamin E were analysed using ELISA technique. Our results showed significant increase of G2 GPT, ALP, GGT, TG, glucose, TC and AOPP, versus G1 ( P [ 0.05) and a significant decrease of G2 serum TAC and vitamin E versus G1 results ( p = 0.01 and 0.01). Vitamin E nanoparticles (G3) caused a significant increase of TAC and significant decrease of serum AOPP, versus G2 (p [ 0.01). Results showed a significant reduction of GPT, GGT, ALP, TG and total cholesterol ( p [0.05) in G3 versus G2. PLGA nanoparticles should be considered an attractive and promising alternative to improve the bioavailability and biological activity of vitaminE.
Keywords:
nanoparticles; vitamin E; oxidative stress; liver disease

Issue: 2019, Volume 70, Issue 1
Pages: 78-83
Publication date: 15/02/2019
https://doi.org/10.37358/RC.19.1.6855
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
TOTAN, A., BALAN, D.G., MIRICESCU, D., RADULESCU, R., STANESCU, I.I., VIRGOLICI, B., MOHORA, M., GREABU, M., Nonalcoholic Fatty Liver Disease and Vitamin E - A Promising Relationship?, Rev. Chim., 70(1), 2019, 78-83.

Vancouver
Totan A, Balan DG, Miricescu D, Radulescu R, Stanescu II, Virgolici B, Mohora M, Greabu M. Nonalcoholic Fatty Liver Disease and Vitamin E - A Promising Relationship?. Rev. Chim.[internet]. 2019 Jan;70(1):78-83. Available from: https://doi.org/10.37358/RC.19.1.6855


APA 6th edition
Totan, A., Balan, D.G., Miricescu, D., Radulescu, R., Stanescu, I.I., Virgolici, B., Mohora, M. & Greabu, M. (2019). Nonalcoholic Fatty Liver Disease and Vitamin E - A Promising Relationship?. Revista de Chimie, 70(1), 78-83. https://doi.org/10.37358/RC.19.1.6855


Harvard
Totan, A., Balan, D.G., Miricescu, D., Radulescu, R., Stanescu, I.I., Virgolici, B., Mohora, M., Greabu, M. (2019). 'Nonalcoholic Fatty Liver Disease and Vitamin E - A Promising Relationship?', Revista de Chimie, 70(1), pp. 78-83. https://doi.org/10.37358/RC.19.1.6855


IEEE
A. Totan, D.G. Balan, D. Miricescu, R. Radulescu, I.I. Stanescu, B. Virgolici, M. Mohora, M. Greabu, "Nonalcoholic Fatty Liver Disease and Vitamin E - A Promising Relationship?". Revista de Chimie, vol. 70, no. 1, pp. 78-83, 2019. [online]. https://doi.org/10.37358/RC.19.1.6855


Text
Alexandra Totan, Daniela Gabriela Balan, Daniela Miricescu, Radu Radulescu, Iulia Ioana Stanescu, Bogdana Virgolici, Maria Mohora, Maria Greabu,
Nonalcoholic Fatty Liver Disease and Vitamin E - A Promising Relationship?,
Revista de Chimie,
Volume 70, Issue 1,
2019,
Pages 78-83,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.1.6855.
(https://revistadechimie.ro/Articles.asp?ID=6855)
Keywords: nanoparticles; vitamin E; oxidative stress; liver disease


RIS
TY - JOUR
T1 - Nonalcoholic Fatty Liver Disease and Vitamin E - A Promising Relationship?
A1 - Totan, Alexandra
A2 - Balan, Daniela Gabriela
A3 - Miricescu, Daniela
A4 - Radulescu, Radu
A5 - Stanescu, Iulia Ioana
A6 - Virgolici, Bogdana
A7 - Mohora, Maria
A8 - Greabu, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 1
SP - 78
EP - 83
UR - https://doi.org/10.37358/RC.19.1.6855
KW - nanoparticles
KW - vitamin E
KW - oxidative stress
KW - liver disease
ER -


BibTex
@article{RevCh2019P78,
author = {Totan Alexandra and Balan Daniela Gabriela and Miricescu Daniela and Radulescu Radu and Stanescu Iulia Ioana and Virgolici Bogdana and Mohora Maria and Greabu Maria},
title = {Nonalcoholic Fatty Liver Disease and Vitamin E - A Promising Relationship?},
journal = {Revista de Chimie},
volume = {70},
number = {1},
pages = {78-83},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.1.6855},
url = {https://revistadechimie.ro/Articles.asp?ID=6855}
}
 
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