The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis

Chis, Irina C.; Baltaru, Doina; Clichici, Simona; Oniga, Ovidiu; Cojocaru, Ileana; Nastasa, Cristina

Irina C. Chis, Doina Baltaru, Simona Clichici, Ovidiu Oniga, Ileana Cojocaru, Cristina Nastasa

The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis

Abstract:

Rheumatoid arthritis (RA) is a chronic inflammatory disease that reduces life quality and requires long-life therapy. Quercetin (Que) is a natural flavonoid with antioxidant and anti-inflammatory effects. (3-(2-(4-Chlorophenyl)-2-oxoethyl)-5-((6-methyl-4-oxo-4H-chromen-3-yl)methylene) thiazolidine-2,4-dione (TZD) is a thiazolidinedione derivative synthesized in our laboratory. This study was designed to investigate the antioxidant effects of the Que and TZD derivative administration in adjuvant-induced arthritic (AIA) rats. AIA was induced in Wistar rats by the intraplantar injection of Freund’s complete adjuvant (FCA), unilaterally in the right hind paw. The control non-arthritic rats and the arthritic rats were treated with Que (30 mg/kg/day) or TZD derivative (12 mg/kg/day) for 21 days. The antioxidant effects of 5-chromen-yl- thiazolidinedione were compared to Que. The serum levels of malondialdehyde (MDA) and protein carbonyl (PC) groups, the superoxide dismutase (SOD) and catalase (CAT) activity were assessed. AIA rats showed significatly increased oxidative stress parameter levels in the blood. The results indicated that the TZD derivative decreased the blood oxidative stress parameters in the treated arthritic rats, compared to Que. The antioxidant effects of 5-chromen-yl-thiazolidinedione in AIA suggest its therapeutic properties for the clinical treatment of RA.

Keywords:
oxidative stress; adjuvant-induced arthritis; quercetin; 5-chromenyl-thiazolidinedione

Issue: 2018, Volume 69, Issue 9

Pages: 2361-2365

Publication date: 2018/10/15

https://doi.org/10.37358/RC.18.9.6534

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Citation Styles

Cite this article as:
CHIS, I.C., BALTARU, D., CLICHICI, S., ONIGA, O., COJOCARU, I., NASTASA, C., The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis, Rev. Chim., 69(9), 2018, 2361-2365.

Vancouver
Chis IC, Baltaru D, Clichici S, Oniga O, Cojocaru I, Nastasa C. The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis. Rev. Chim.[internet]. 2018 Sep;69(9):2361-2365. Available from: https://doi.org/10.37358/RC.18.9.6534

APA 6th edition
Chis, I.C., Baltaru, D., Clichici, S., Oniga, O., Cojocaru, I. & Nastasa, C. (2018). The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis. Revista de Chimie, 69(9), 2361-2365. https://doi.org/10.37358/RC.18.9.6534

Harvard
Chis, I.C., Baltaru, D., Clichici, S., Oniga, O., Cojocaru, I., Nastasa, C. (2018). 'The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis', Revista de Chimie, 69(9), pp. 2361-2365. https://doi.org/10.37358/RC.18.9.6534

IEEE
I.C. Chis, D. Baltaru, S. Clichici, O. Oniga, I. Cojocaru, C. Nastasa, "The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis". Revista de Chimie, vol. 69, no. 9, pp. 2361-2365, 2018. [online]. https://doi.org/10.37358/RC.18.9.6534

Text
Irina C. Chis, Doina Baltaru, Simona Clichici, Ovidiu Oniga, Ileana Cojocaru, Cristina Nastasa,
The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis,
Revista de Chimie,
Volume 69, Issue 9,
2018,
Pages 2361-2365,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.9.6534.
(https://revistadechimie.ro/Articles.asp?ID=6534)
Keywords: oxidative stress; adjuvant-induced arthritis; quercetin; 5-chromenyl-thiazolidinedione

RIS
TY - JOUR
T1 - The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis
A1 - Chis, Irina C.
A2 - Baltaru, Doina
A3 - Clichici, Simona
A4 - Oniga, Ovidiu
A5 - Cojocaru, Ileana
A6 - Nastasa, Cristina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 9
SP - 2361
EP - 2365
UR - https://doi.org/10.37358/RC.18.9.6534
KW - oxidative stress; adjuvant-induced arthritis; quercetin
KW - 5-chromenyl-thiazolidinedione
ER -

BibTex
@article{RevCh2018P2361,
author = {Chis Irina C. and Baltaru Doina and Clichici Simona and Oniga Ovidiu and Cojocaru Ileana and Nastasa Cristina},
title = {The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis},
journal = {Revista de Chimie},
volume = {69},
number = {9},
pages = {2361-2365},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.9.6534},
url = {https://revistadechimie.ro/Articles.asp?ID=6534}
}

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