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Revista de Chimie (Rev. Chim.), Year 2016, Volume 67, Issue 12,





ADRIANA LEDETI, GABRIELA VLASE, DENISA CIRCIOBAN, IONUT LEDETI, LAVINIA STELEA, TITUS VLASE, ANGELA CAUNII
Comparative Stability of Levodopa Under Thermal Stress in both Oxidative and Inert Media

Abstract:

This study aims towards a comparative stability of an amino-acid under thermal stress in both oxidative and inert media, namely Levodopa, which is up to the date the primary antiparkinsonian medication. The identity and purity of the sample was firstly confirmed by UATR-FTIR spectroscopy, and later thermal analysis was employed as an investigational tool for a preliminary view over the stability of the compound. Thermal analysis indicate a similar thermal stability in both media, with no mass loss up to 250 °C, but HF data indicate different thermal events as contributions to degradation. Keywords: levodopa, thermal stability, inert atmosphere, oxidative atmosphere, FTIR


Issue: 2016, Volume 67, Issue 12
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