VASILICA TOMA, DANIEL PETRU CIOLOCA, DORIANA AGOP FORNA, LOREDANA HURJUI, GINA IOSEFINA BOTNARIU, IRINA ELENA NECHIFOR, MARIA BOGDAN, MARCEL COSTULEANU, LAURENTIU SIMION, CATALINA HOLBAN<br>IL 18 as an Important Gingival Inflammatory Biochemical Marker in Children and Adolescents with Insulin-Dependent Diabetes Mellitus

VASILICA TOMA, DANIEL PETRU CIOLOCA, DORIANA AGOP FORNA, LOREDANA HURJUI, GINA IOSEFINA BOTNARIU, IRINA ELENA NECHIFOR, MARIA BOGDAN, MARCEL COSTULEANU, LAURENTIU SIMION, CATALINA HOLBAN
IL 18 as an Important Gingival Inflammatory Biochemical Marker in Children and Adolescents with Insulin-Dependent Diabetes Mellitus

Abstract:

Interleukin 18 (IL-18) might mediate the gingival inflammation with increased potency in patients with diabetes. To establish possible positive correlations between the degree of gingival inflammation and IL-18 amounts in gingival crevicular fluid (GCF) of children and adolescents with insulin-dependent diabetes. Clinical and GCF IL-18 assessment were performed on 30 children and adolescents with diabetes and 30 healthy subjects. GCF samples were collected from mesial sites of incisors and first permanent molars for all subjects, the level of IL-18 being determined by ELISA. The highest concentrations of IL 18 were recorded in IDD children with severe gingivitis. In all studied groups, the IL 18 values were higher at the level of the incisors. Based on clinical indices, no cases of chronic marginal or aggressive periodontitis were diagnosed. The IL 18 concentration in the GCF increases proportionally with progression toward periodontal inflammation and is strongly associated with the presence of diabetes. The results suggest that the periodontal impairment can start very early in children with diabetes. The inflammation monitored with the IL 18 levels in the GCF was much more obvious and earlier detected than by clinical indices. Moreover, IL 18 can be a prognostic marker of the periodontal inflammation in patients with diabetes where the clinical alterations are not yet evident. Keywords: interleukin 18, biomarker, gingival crevicular fluid, insulinodependent diabetes mellitus, periodontitis, children, adolescents

Issue: 2016, Volume 67, Issue 12

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