DAN NAVOLAN, SIMONA VLADAREANU, IOANA CIOHAT, DANA STOIAN, DIANA BADIU, MARIUS CRAINA, MIROSLAV TOMOVIC, FLORIN BIRSASTEANU, MIHAELA CRACIUNESCU<br>A Preliminary Study over Second Trimester Biochemical<br> Markers and Their Clinical Utility

DAN NAVOLAN, SIMONA VLADAREANU, IOANA CIOHAT, DANA STOIAN, DIANA BADIU, MARIUS CRAINA, MIROSLAV TOMOVIC, FLORIN BIRSASTEANU, MIHAELA CRACIUNESCU
A Preliminary Study over Second Trimester Biochemical
Markers and Their Clinical Utility

Abstract:

Identification of early markers of pregnancy complications is a goal of materno-fetal medicine. The main purpose of the study was to see if changes in second trimester markers concentration are associated with IUGR and PIH complicated pregnancies. Was analyzed second trimester biochemical markers concentration in seven groups of pregnant women: with birth at term without pregnancy complications (BT) (Group A; n=1628), with SGA without PIH (Group B; n=39), with PIH without SGA (Group C; n=26), with PIH and SGA (Group D; n=6), with PIH or SGA (Group E; n=71), with PIH including SGA (Group F; n=32), and SGA including PIH (Group G; n=45). Second trimester hCG concentration is higher in BT group compared to group E (1.07±0.01 vs. 0.93±0.05, p=0.08) and group G (1.07±0.01 vs. 0.93±0.04, p=0.05), whereas uE3 concentration is lower in group A compared to group D (0.95±0.09 vs. 1.28±0.27; p=0.07), E (0.95±0.09 vs. 1.01±0.05; p=0.08) and group G (0.95±0.09 vs. 1.12±0.11; p=0.06). Our study showed that hCG value is higher while uE3 is lower in group A compared to group E and group G pregnant women. Keywords: second trimester, biochemical markers, prediction, SGA, PIH

Issue: 2016, Volume 67, Issue 6

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