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Revista de Chimie (Rev. Chim.), Year 2016, Volume 67, Issue 6,





Radu Florin Mocan Hognogi, Nicolae Costin, Andrei Malutan, Razvan Ciortea, Dan Mihu
Reaction and the Effectiveness of Injectable Oestrogen
Treatment, Initiated with Estradiol, Estradurin, Sintofolin

Abstract:

The purpose of this study has been to identify the reaction occurring at the level of the vulvovaginal epithelium in ovariectomised female rats, after the administration of injectable oestrogens. We have studied 30 female Wistar white rats, with control group. 15 days after surgery, the hormonal substitution therapy with injectable oestrogens was initiated (Estradiol, Estradurin, Sintofolin), with a dosage of 0.2 mg/rat/day, and after 14 days of treatment, all animals were sacrificed and biopsies at vaginal and vulvar levels were taken from all groups, the samples being then subjected to a histopathological examination. Our study has shown the prompt reaction and increased receptivity of the vulvovaginal epithelium to the administration of oestrogens, after bilateral ovariectomy. Moreover, we have demonstrated that Estradiol treatment yields the promptest response, compared to synthetic oestrogen therapy, such as Estradurin or Sintofolin. Keywords: menopause, oestrogenic receptors, reaction mechanism, atrophy, vulvovaginal hypertrophic, chemical structure


Issue: 2016, Volume 67, Issue 6
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