OANA VIOLA BADULESCU, MADALINA MOCANU, CRISTINA  ELENA IANCU, MARIA MAGDALENA  LEON CONSTNTIN,  MAGDA BADESCU<br>Assessment of Hematological Toxicity in Case of Oral Administration of Metronidazole

OANA VIOLA BADULESCU, MADALINA MOCANU, CRISTINA ELENA IANCU, MARIA MAGDALENA LEON CONSTNTIN, MAGDA BADESCU
Assessment of Hematological Toxicity in Case of Oral Administration of Metronidazole

Abstract:

Metronidazole is an antibacterial agent, which is part of nitroimidazole class. It is used, particularly, in the treatment of infections caused by anaerobic bacteria and protozoa. Metronidazole, orally administered, is recommended for the treatment of infections with anaerobic germs, specifically in the genitalia area (bacterial vaginitis) and in the abdominal area (Crohn’s disease, necrotising pancreatitis, gastritis) and it is a treatment prescribed in infection with Clostridium difficile (pseudomembranous colitis). Metronidazole is also frequently prescribed in the treatment of infection with Helicobacter pylori. Severe adverse effects induced by the intake of Metronidazole are known, such as: convulsive crises, encephalopathy, peripheral neuropathy, reversible neutropenia. The aim of this paper is to present the involvement of Metronidazole in the alteration of platelet function, pathology occurred in form of severe peripheral thrombocytopenia. We present the case of a 59-year old woman, diagnosed with gastritis with Helicobacter pylori, who, after having taken Metronidazole in order to fight the infection, presents severe hemorrhagic syndrome. Thrombocytopenia induced by Metronidazole is a rare adverse reaction, induced by immune mechanism. It is characterised by hemorrhagipar syndrome which occurs after primary haemostasis and clinically manifests at cutaneous-mucous level. Keywords: toxicity, Metronidazole, thrombocytopenia, anti-platelet antibodies, haemostasis

Issue: 2016, Volume 67, Issue 6

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