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Revista de Chimie (Rev. Chim.), Year 2016, Volume 67, Issue 6,





Diana S. Antal, Iulia Pinzaru, Florin Borcan, TEODORA DANIELA MARTI, Ionut Ledeti, Dorina Coricovac, Stefan Schwaiger, Hermann Stuppner, Cristina A. Dehelean, Evelyne Ollivier, Codruta Soica
Inclusion Complexes of the Aurone Sulfuretin and the Chalcone
Butein from Cotinus coggygria Wood in Two Cyclodextrin Types
First data on physico-chemical properties

Abstract:

The quest for new drug leads derived from natural products is a mainstay of today’s pharmaceutical research. Aurones and chalcones are flavonoid subclasses with high therapeutic potential but disadvantaged by poor water solubility. Cyclodextrins (CDs) are recognized drug carriers, able to accommodate hydrophobic drugs and enhance pharmacokinetic properties. The current research presents, as a first step, the extraction of two highly bioactive flavonoids, the aurone sulfuretin and the chalcone butein, from the wood of the European smoke tree (Cotinus coggygria Scop.). Subsequently, each of the flavonoids was included, for the first time, in two cyclodextrin types, resulting four types of complexes. Hydroxypropyl-b-CD and randomely methylated-b-CD were employed at a ratio of 1:2 = guest: host. Complex formation, stability and particle size were assessed, providing first physico-chemical data on these novel sulfuretin-CD and butein-CD entities. Keywords: Sulfuretin, Butein, cyclodextrin complexation


Issue: 2016, Volume 67, Issue 6
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