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Revista de Chimie (Rev. Chim.), Year 2016, Volume 67, Issue 6,





LAURENTIA N. GALES, RODICA ANGHEL, MARIA IULIANA GRUIA, ION GRUIA, ADRIAN BIRLOIU, ALEXANDRA RALUCA MIRON
A Study Regarding Boron Metabolism at Experimental Animals
in Order to Achieve Neutron Irradiation in Boron Capture

Abstract:

In order to obtain a first experimental model of BNCT irradiation on experimental animals in Romania we made some experiments in order to characterize boron metabolism. After the first laboratory study regarding BPA use in cancer radiotherapy via neutron capture were assessed the following issues: BPA is a substance with a limited degree of solubility in aqueous solvents. Our results allow the selection of conditioned aqueous systems which provides an increased BPA solubility degree, ranging between 30-40 mg / mL allowing the saturation with BPA in the tumor cell in order that neutron capture reaction to take place and release a particles with high linear energy transfer, effective in the therapy; BPA is a molecule with affinity for HRS1 type tumor cells being captured and accumulated at maximum values in the range 3-5 h after intravenous injection; the BPA internalization degree in HUH-7-17 type tumor cells depends on BPA concentration, a concentration of 20-40 mg BPA for about 105-106 tumor cells ensures a maximum internalization degree. Keywords:boron metabolism, liver cancer, experimental animals, irradiation


Issue: 2016, Volume 67, Issue 6
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