MADALINA MOCANU, MAGDA BADESCU, MARIA-MAGDALENA LEON CONSTANTIN, IULIAN-COSTIN LUPU, OANA-VIOLA BADULESCU<br>Assessment of Haematological Toxicity of Inhaled <br>4-methylethcathinone and 1-pentyl-3-(1-naphthoyl) Indole

MADALINA MOCANU, MAGDA BADESCU, MARIA-MAGDALENA LEON CONSTANTIN, IULIAN-COSTIN LUPU, OANA-VIOLA BADULESCU
Assessment of Haematological Toxicity of Inhaled
4-methylethcathinone and 1-pentyl-3-(1-naphthoyl) Indole

Abstract:

The consumption of new substances with psychoactive properties, known under the name of Ethno-botanicals, has drawn attention, in the latest years, with their negative effects on the life of children and teenagers who consumed them but also with the rapid and visible development of the phenomenon among the population, in general. Haematological toxicity of some chemical substances contained in these products is more often met in medical practice. Limited information regarding the real content, and also the diversity of the substances incorporated in these chemicals, hinder the strict analysis of the toxicity of each constituent separately. The purpose of this article is to highlight the involvement of 4-methylethcathinone (4-MEC) and 1-pentyl-3-(1-naphthoyl) indole in the occurring of severe thrombocytopenia, at a young person of 21 years old, a chronic consumer of hallucinogenic combinations that contain these two substances preponderantly. The young man says that he has inhaled these substances. Thrombocytopenic purpura may be primary or secondary to other associated pathologies. Also, secondary purpura may be induced by the consumption of some toxic, medicine-related or hallucinogenic substances. It is a haematological disorder, characterized by a low number of platelets in peripheral blood (below 100.000/mm3, the normal value being =150.000-400.000/mmc). From the clinical point of view, thrombocytopenia manifests by cutaneous-mucous haemorrhage syndrome: petechiae, ecchymoses, gingivorragia, epistaxis, haemorrhages at the level of various organs, some of them having vital risk. Keywords: thrombocytopenia, 4-methylethcathinone, 1-penthyl-3-(1-naphthoyl) indole, haematological toxicity

Issue: 2015, Volume 66, Issue 8

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