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Revista de Chimie (Rev. Chim.), Year 2015, Volume 66, Issue 8,





Tunde Jurca, Eleonora Marian, Bogdan Tita, Gheza Bandur, Dumitru Tita, Narcis Duteanu
Comparative Studies of Pentoxifylline - Active Substance and Tablets

Abstract:

Pentoxifylline, 1-(5-oxohexyl)-3,7-dimethylxanthine, is an active haemorheological drug which is widely used for treatment of intermittent claudication and other circulatory disorders.The scanning electron microscope (SEM) is one of the most versatile instruments available for the nondestructive examination and analysis of the microstructure, morphology and chemical composition characterizations of pharmaceuticals. Scanning electron microscopy provides visual information about the organic and inorganic submicron particles (size, shape, and morphology), and also chemical identification based on the X-ray energy lines. FT-IR spectroscopy, DSC (differential scanning calorimetry) and X-ray powder diffraction (XRPD) were used as complementary techniques to adequately implement and assist in interpretation of the SEM results. Based on all this data we can say that the commercial product was observed to have physical interactions between the active compound and used excipients. Keywords: pentoxifylline, SEM, FT-IR, XRD, DSC


Issue: 2015, Volume 66, Issue 8
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