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Revista de Chimie (Rev. Chim.), Year 2014, Volume 65, Issue 12,





GABRIELA MARINESCU, DANIELA C. CULITA, LUMINITA PATRON, SULTANA NITA, LUMINITA MARUTESCU, OVIDIU OPREA
Novel Complexes of La(III), Pr(III), Nd(III) with Piroxicam Synthesis, characterization and antimicrobial studies

Abstract:

This article reports the synthesis of novel rare-earth coordination complexes with piroxicam. Microanalytical data, magnetic susceptibility, conductivity data, IR, UV-Vis spectroscopy and termogravimetric analysis were used to confirm their compositions and structure. The molecular formula proposed for these complexes is the following Ln2(HPir)2(CH3COO)4ยท2H2O (Ln = La(III), Pr(III), Nd(III)). All complexes and piroxicam were screened for their antimicrobial activity against 7 microbial strains: Enterococcus faecium E5, Escherichia coli ATCC 25922, Candida albicans 1760, Pseudomonas aeruginosa ATCC 27857, Bacillus subtillis ATCC 6683, Staphylococcus aureus ATCC 6538, Klebsiella pneumoniae IC 13420. The ability of the compounds to inhibit the microbial adherence to the inert substrata was also evaluated. The results demonstrated that the tested compounds exhibit moderate antimicrobial and antibiofim activity. Keywords: piroxicam, lanthanides, coordination compounds, antimicrobial activity


Issue: 2014, Volume 65, Issue 12
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