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Revista de Chimie (Rev. Chim.), Year 2009, Volume 60, Issue 9,





Loredana Elena Vîjan
Interaction of Amphotericin B with Ricinoleic Acid and
12-(cholesteryloxicarbonyloxi)-9-Octadecenoic Acid

Abstract:

The interaction between amphotericin B and ricinoleic acid, respectively 12-(cholesteryloxicarbonyloxi)-9-octadecenoic acid has been studied by UV-Vis absorption spectroscopy, in order to determine of the binding parameters: the number of binding sites (n) and the binding constant (K). The results were rationalized in terms of several literature models: Benesi-Hildebrand, Scott and Scatchard, taking into account both 1:1 drug - sterol system and cooperativity effects. Keywords: amphotericin B, ricinoleic acid, 12-(cholesteryloxicarbonyloxi)-9-octadecenoic acid, UV-Vis absorption spectroscopy


Issue: 2009, Volume 60, Issue 9
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