The Effect of Aluminium on Bone Mineralization - changes in Some Trace Elements and Macroelements

Vermesan, Horia; Pup, Mihaela; Ahmadi, Mirela; Olariu, Lucia; Vermesan, Dinu; Prejbeanu, Radu

Horia Vermesan, Mihaela Pup, Mirela Ahmadi, Lucia Olariu, Dinu Vermesan, Radu Prejbeanu

The Effect of Aluminium on Bone Mineralization - changes in Some Trace Elements and Macroelements

Abstract:

The aim of this study was to determine how mineral composition of bone is modified after administration of AlCl3 solution, alone or in association with citrate. The experiment was made on biological systems - domestic rabbits. We had three working groups. One control group (C - we administrated NaCl 0.9% solution) and two experimental groups (E1 - we administrated 50 mg AlCl3/kg b.w. and E2 - we administrated 50 mg AlCl3/kg b.w. associated with 2% m/v citrate from sodium citrate). The quantitative analyses for Na, K, Mg, Ca, and Al were made on Atomic Absorption Spectroscopy after a wet digestion using a Microwave System. The results showed that the most important changes were in bone mineralization after aluminum chloride administration (for E1), excepting of aluminum concentration in bone after aluminum administration in association with citrate (for E2). So, aluminum enhances the concentration of some biometals in bone (Na, K, Ca and Mg) with 15-32%, but after administration of aluminum with citrate the aluminum concentration in bone increased with 76%. The results demonstrate that bone is a target tissue for aluminum accumulation.

Keywords:
aluminum chloride; citrate; biological systems; bone

Issue: 2008, Volume 59, Issue 8

Pages:

Publication date: 2008/9/9

https://doi.org/10.37358/RC.08.8.1913

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This article is published under the Creative Commons Attribution 4.0 International License

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