Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy

Rotaru, Andreea; Albu, Carmen Valeria; Tudorascu, Diana Rodica; Catalin, Bogdan; Gheonea, Mihaela; Udristoiu, Ion; Iancau, Maria

Andreea Rotaru, Carmen Valeria Albu, Diana Rodica Tudorascu, Bogdan Catalin, Mihaela Gheonea, Ion Udristoiu, Maria Iancau

Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy

Abstract:

Diabetic neuropathy is the most common cause of neuropathy worldwide and it is estimated to affect about half of people with diabetes. The goal of our study is to compare the effectiveness of thioctic acid treatment alone versus the efficacy of thioctic acid plus vitamin B complex in patients with diabetic peripheral polyneuropathy (DPN). We conducted a prospective, observational study staring from October 2017 to December 2018, in which we included 56 DPN patients. Depending on the Michigan neuropathic screening instrument (MNSI) we divided the patients into two subgroups: patients with MNSI [7 and patients whose MNSI did not decrease sufficiently during the therapeutic protocol. 36 patients (64.2%) of the total patients enrolled in the study had an MNSI [7 at one of the follow-up meetings. These patients were also divided according to the therapeutic protocol applied in a group of patients who were treated with only thioctic acid (TA group) and in a group of patients who were treated with thioctic acid plus vitamin B complex (TA + B group). We noticed a greater proportion of patients who had a MNSI [7 in the TA + B group. This study revealed that the treatment of peripheral diabetic neuropathy with thioctic acid plus Vitamin B complex compared to thioctic acid alone was superior in terms of improving clinical features.

Keywords:
diabetes mellitus; thioctic acid; Vitamin B complex; diabetic peripheral neuropathy

Issue: 2019, Volume 70, Issue 10

Pages: 3614-3617

Publication date: 2019/11/15

https://doi.org/10.37358/RC.19.10.7607

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ROTARU, A., ALBU, C.V., TUDORASCU, D.R., CATALIN, B., GHEONEA, M., UDRISTOIU, I., IANCAU, M., Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy, Rev. Chim., 70(10), 2019, 3614-3617.

Vancouver
Rotaru A, Albu CV, Tudorascu DR, Catalin B, Gheonea M, Udristoiu I, Iancau M. Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy. Rev. Chim.[internet]. 2019 Oct;70(10):3614-3617. Available from: https://doi.org/10.37358/RC.19.10.7607

APA 6th edition
Rotaru, A., Albu, C.V., Tudorascu, D.R., Catalin, B., Gheonea, M., Udristoiu, I. & Iancau, M. (2019). Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy. Revista de Chimie, 70(10), 3614-3617. https://doi.org/10.37358/RC.19.10.7607

Harvard
Rotaru, A., Albu, C.V., Tudorascu, D.R., Catalin, B., Gheonea, M., Udristoiu, I., Iancau, M. (2019). 'Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy', Revista de Chimie, 70(10), pp. 3614-3617. https://doi.org/10.37358/RC.19.10.7607

IEEE
A. Rotaru, C.V. Albu, D.R. Tudorascu, B. Catalin, M. Gheonea, I. Udristoiu, M. Iancau, "Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy". Revista de Chimie, vol. 70, no. 10, pp. 3614-3617, 2019. [online]. https://doi.org/10.37358/RC.19.10.7607

Text
Andreea Rotaru, Carmen Valeria Albu, Diana Rodica Tudorascu, Bogdan Catalin, Mihaela Gheonea, Ion Udristoiu, Maria Iancau,
Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy,
Revista de Chimie,
Volume 70, Issue 10,
2019,
Pages 3614-3617,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.10.7607.
(https://revistadechimie.ro/Articles.asp?ID=7607)
Keywords: diabetes mellitus; thioctic acid; Vitamin B complex; diabetic peripheral neuropathy

RIS
TY - JOUR
T1 - Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy
A1 - Rotaru, Andreea
A2 - Albu, Carmen Valeria
A3 - Tudorascu, Diana Rodica
A4 - Catalin, Bogdan
A5 - Gheonea, Mihaela
A6 - Udristoiu, Ion
A7 - Iancau, Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 10
SP - 3614
EP - 3617
UR - https://doi.org/10.37358/RC.19.10.7607
KW - diabetes mellitus
KW - thioctic acid
KW - Vitamin B complex
KW - diabetic peripheral neuropathy
ER -

BibTex
@article{RevCh2019P3614,
author = {Rotaru Andreea and Albu Carmen Valeria and Tudorascu Diana Rodica and Catalin Bogdan and Gheonea Mihaela and Udristoiu Ion and Iancau Maria},
title = {Thioctic Acid and Vitamin B Complex Improves Clinical Sings in Diabetic Peripheral Neuropathy},
journal = {Revista de Chimie},
volume = {70},
number = {10},
pages = {3614-3617},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.10.7607},
url = {https://revistadechimie.ro/Articles.asp?ID=7607}
}

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