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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 10, 3603-3610

https://doi.org/10.37358/RC.19.10.7605

Madalina Mihalache, Cornelia Guran, Aurelia Meghea, Vasile Bercu, Ludmila Motelica, Alina Maria Holban

Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity

Abstract:

The three copper complexes having a-ketoglutaric acid (H2A) and 1- (o-tolyl) biguanide (TB) ligands have been synthesized and characterized. The proposed formulas for these complexes are: [Cu(TB)(HA)]Cl (C1), [Cu(TB)(HA)CH3COO]•H2O (C2) and [Cu(TB)(HA)](NO3) (C3) where HA represents deprotonated H2A. The complexes obtained were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, antifungal activity on Candida albicans ATCC 10231 and antitumor activity on HeLa tumor cells. Due to the antitumor, antifungal, antimicrobial activity and inhibition of inert substrate adhesion, complexes synthesized could be used for potential therapeutic applications.
Keywords:
1-(o-tolyl)biguanide; a-ketoglutaric acid; copper complexes; antibacterial activity; celule HeLa; antifungal activity

Issue: 2019, Volume 70, Issue 10
Pages: 3603-3610
Publication date: 2019/11/15
https://doi.org/10.37358/RC.19.10.7605
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MIHALACHE, M., GURAN, C., MEGHEA, A., BERCU, V., MOTELICA, L., HOLBAN, A.M., Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity, Rev. Chim., 70(10), 2019, 3603-3610.

Vancouver
Mihalache M, Guran C, Meghea A, Bercu V, Motelica L, Holban AM. Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity. Rev. Chim.[internet]. 2019 Oct;70(10):3603-3610. Available from: https://doi.org/10.37358/RC.19.10.7605


APA 6th edition
Mihalache, M., Guran, C., Meghea, A., Bercu, V., Motelica, L. & Holban, A.M. (2019). Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity. Revista de Chimie, 70(10), 3603-3610. https://doi.org/10.37358/RC.19.10.7605


Harvard
Mihalache, M., Guran, C., Meghea, A., Bercu, V., Motelica, L., Holban, A.M. (2019). 'Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity', Revista de Chimie, 70(10), pp. 3603-3610. https://doi.org/10.37358/RC.19.10.7605


IEEE
M. Mihalache, C. Guran, A. Meghea, V. Bercu, L. Motelica, A.M. Holban, "Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity". Revista de Chimie, vol. 70, no. 10, pp. 3603-3610, 2019. [online]. https://doi.org/10.37358/RC.19.10.7605


Text
Madalina Mihalache, Cornelia Guran, Aurelia Meghea, Vasile Bercu, Ludmila Motelica, Alina Maria Holban,
Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity,
Revista de Chimie,
Volume 70, Issue 10,
2019,
Pages 3603-3610,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.10.7605.
(https://revistadechimie.ro/Articles.asp?ID=7605)
Keywords: 1-(o-tolyl)biguanide; a-ketoglutaric acid; copper complexes; antibacterial activity; celule HeLa; antifungal activity


RIS
TY - JOUR
T1 - Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity
A1 - Mihalache, Madalina
A2 - Guran, Cornelia
A3 - Meghea, Aurelia
A4 - Bercu, Vasile
A5 - Motelica, Ludmila
A6 - Holban, Alina Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 10
SP - 3603
EP - 3610
UR - https://doi.org/10.37358/RC.19.10.7605
KW - 1-(o-tolyl)biguanide
KW - a-ketoglutaric acid
KW - copper complexes
KW - antibacterial activity
KW - celule HeLa
KW - antifungal activity
ER -


BibTex
@article{RevCh2019P3603,
author = {Mihalache Madalina and Guran Cornelia and Meghea Aurelia and Bercu Vasile and Motelica Ludmila and Holban Alina Maria},
title = {Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity},
journal = {Revista de Chimie},
volume = {70},
number = {10},
pages = {3603-3610},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.10.7605},
url = {https://revistadechimie.ro/Articles.asp?ID=7605}
}
 
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