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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 10, 3564-3569

https://doi.org/10.37358/RC.19.10.7597

Rahila Huma, Tariq Mahmud, Liviu Mitu, Muhammad Ashraf, Ambar Iqbal, Kiran Iftikhar, Anum Hayat

Synthesis, Characterization, Molecular Docking and Enzyme Inhibition Studies of Some Novel Enaminone Derivatives and Their Complexes with Cu(II), Cd(II) and Co(II) Ions

Abstract:

Two new enaminone ligands, 3-chloro-4-{(4-chlorophenyl)amino}pent-3-en-2-one (Ac-PCA), 4-(benzylamino)-3-chloropent-3-en-2-one (Ac-BA) and their metal complexes with transition metal ions [Cu(II), Cd(II) and Co(II)] were prepared and subsequently characterized by FTIR, ICP-AES, UV-Vis, TGA, 1H NMR, 13C NMR and FAB-MS. These newly synthesized compounds were further investigated for anti-acetylcholinesterase (AChE) and anti-urease activities. The (Ac-BA)Cu(II) complex exhibited good anti-AChE while (Ac-BA)2Co(II) complex was potent against anti-urease activities. Other ligands and complexes showed poor to no enzyme inhibitory activities. The synthesized compounds were docked inside acetylcholinesterase enzymes to determine their putative binding mode.
Keywords:
Antiureas activity; enaminone; metal complexes; acetylcholinesterase inhibition studies

Issue: 2019, Volume 70, Issue 10
Pages: 3564-3569
Publication date: 2019/11/15
https://doi.org/10.37358/RC.19.10.7597
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This article is published under the Creative Commons Attribution 4.0 International License
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Cite this article as:
HUMA, R., MAHMUD, T., MITU, L., ASHRAF, M., IQBAL, A., IFTIKHAR, K., HAYAT, A., Synthesis, Characterization, Molecular Docking and Enzyme Inhibition Studies of Some Novel Enaminone Derivatives and Their Complexes with Cu(II), Cd(II) and Co(II) Ions, Rev. Chim., 70(10), 2019, 3564-3569.

Vancouver
Huma R, Mahmud T, Mitu L, Ashraf M, Iqbal A, Iftikhar K, Hayat A. Synthesis, Characterization, Molecular Docking and Enzyme Inhibition Studies of Some Novel Enaminone Derivatives and Their Complexes with Cu(II), Cd(II) and Co(II) Ions. Rev. Chim.[internet]. 2019 Oct;70(10):3564-3569. Available from: https://doi.org/10.37358/RC.19.10.7597


APA 6th edition
Huma, R., Mahmud, T., Mitu, L., Ashraf, M., Iqbal, A., Iftikhar, K. & Hayat, A. (2019). Synthesis, Characterization, Molecular Docking and Enzyme Inhibition Studies of Some Novel Enaminone Derivatives and Their Complexes with Cu(II), Cd(II) and Co(II) Ions. Revista de Chimie, 70(10), 3564-3569. https://doi.org/10.37358/RC.19.10.7597


Harvard
Huma, R., Mahmud, T., Mitu, L., Ashraf, M., Iqbal, A., Iftikhar, K., Hayat, A. (2019). 'Synthesis, Characterization, Molecular Docking and Enzyme Inhibition Studies of Some Novel Enaminone Derivatives and Their Complexes with Cu(II), Cd(II) and Co(II) Ions', Revista de Chimie, 70(10), pp. 3564-3569. https://doi.org/10.37358/RC.19.10.7597


IEEE
R. Huma, T. Mahmud, L. Mitu, M. Ashraf, A. Iqbal, K. Iftikhar, A. Hayat, "Synthesis, Characterization, Molecular Docking and Enzyme Inhibition Studies of Some Novel Enaminone Derivatives and Their Complexes with Cu(II), Cd(II) and Co(II) Ions". Revista de Chimie, vol. 70, no. 10, pp. 3564-3569, 2019. [online]. https://doi.org/10.37358/RC.19.10.7597


Text
Rahila Huma, Tariq Mahmud, Liviu Mitu, Muhammad Ashraf, Ambar Iqbal, Kiran Iftikhar, Anum Hayat,
Synthesis, Characterization, Molecular Docking and Enzyme Inhibition Studies of Some Novel Enaminone Derivatives and Their Complexes with Cu(II), Cd(II) and Co(II) Ions,
Revista de Chimie,
Volume 70, Issue 10,
2019,
Pages 3564-3569,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.10.7597.
(https://revistadechimie.ro/Articles.asp?ID=7597)
Keywords: Antiureas activity; enaminone; metal complexes; acetylcholinesterase inhibition studies


RIS
TY - JOUR
T1 - Synthesis, Characterization, Molecular Docking and Enzyme Inhibition Studies of Some Novel Enaminone Derivatives and Their Complexes with Cu(II), Cd(II) and Co(II) Ions
A1 - Huma, Rahila
A2 - Mahmud, Tariq
A3 - Mitu, Liviu
A4 - Ashraf, Muhammad
A5 - Iqbal, Ambar
A6 - Iftikhar, Kiran
A7 - Hayat, Anum
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 10
SP - 3564
EP - 3569
UR - https://doi.org/10.37358/RC.19.10.7597
KW - Antiureas activity
KW - enaminone
KW - metal complexes
KW - acetylcholinesterase inhibition studies
ER -


BibTex
@article{RevCh2019P3564,
author = {Huma Rahila and Mahmud Tariq and Mitu Liviu and Ashraf Muhammad and Iqbal Ambar and Iftikhar Kiran and Hayat Anum},
title = {Synthesis, Characterization, Molecular Docking and Enzyme Inhibition Studies of Some Novel Enaminone Derivatives and Their Complexes with Cu(II), Cd(II) and Co(II) Ions},
journal = {Revista de Chimie},
volume = {70},
number = {10},
pages = {3564-3569},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.10.7597},
url = {https://revistadechimie.ro/Articles.asp?ID=7597}
}
 
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