Iodometric Quantitative Analysis Method of  Ascorbic Acid in Tablets

Georgescu, Costinela Valerica; Gavat, Cristian Catalin; Voinescu, Doina Carina

Costinela Valerica Georgescu, Cristian Catalin Gavat, Doina Carina Voinescu

Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets

Abstract:

Ascorbic acid is a water-soluble vitamin provided with strong antioxidant action, that fulfills an important immune protective role of the body against infections and prevents various cancers appearance. The main goal of this study was to exactly quantify pure ascorbic acid in tablets of two pharmaceuticals. Proposed objective consisted in improvement and application of a iodometric titration method in ascorbic acid quantitative analysis. Ascorbic acid content per tablet in both studied pharmaceuticals was 173.84 mg, very close to official stated amount of active substance (180 mg). Allowed percentage deviation from declared content of pure ascorbic acid was only 3.42 %, below maximum value of ± 5 % imposed by Romanian Pharmacopoeia 10-th Edition, according to European and International standards. Statistical analysis confirmed experimental obtained results and revealed low Standard Error value SE = 0.214476, which has fallen within normal limits. Confidence Level value (95.0 %) = 0.551328 and Standard Deviation SD = 0.525357. were within normal range of values. Relative Standard Deviation (Coefficient of variation or homogeneity) RSD = 26.268% was found below maximum range of accepted values (30-35%). P value = 7.44. 10-6 was located within normal limits, P [ 0.001, so the experimental obtained results has shown highest statistical significance. Thus, studied titration method can be successfully used in quantitative analysis of ascorbic acid from different samples.

Keywords:
ascorbic acid; antioxidant action; quantitative analysis; iodometric titration; statistic study

Issue: 2019, Volume 70, Issue 10

Pages: 3555-3560

Publication date: 2019/11/15

https://doi.org/10.37358/RC.19.10.7595

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GEORGESCU, C.V., GAVAT, C.C., VOINESCU, D.C., Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets, Rev. Chim., 70(10), 2019, 3555-3560.

Vancouver
Georgescu CV, Gavat CC, Voinescu DC. Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets. Rev. Chim.[internet]. 2019 Oct;70(10):3555-3560. Available from: https://doi.org/10.37358/RC.19.10.7595

APA 6th edition
Georgescu, C.V., Gavat, C.C. & Voinescu, D.C. (2019). Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets. Revista de Chimie, 70(10), 3555-3560. https://doi.org/10.37358/RC.19.10.7595

Harvard
Georgescu, C.V., Gavat, C.C., Voinescu, D.C. (2019). 'Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets', Revista de Chimie, 70(10), pp. 3555-3560. https://doi.org/10.37358/RC.19.10.7595

IEEE
C.V. Georgescu, C.C. Gavat, D.C. Voinescu, "Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets". Revista de Chimie, vol. 70, no. 10, pp. 3555-3560, 2019. [online]. https://doi.org/10.37358/RC.19.10.7595

Text
Costinela Valerica Georgescu, Cristian Catalin Gavat, Doina Carina Voinescu,
Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets,
Revista de Chimie,
Volume 70, Issue 10,
2019,
Pages 3555-3560,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.10.7595.
(https://revistadechimie.ro/Articles.asp?ID=7595)
Keywords: ascorbic acid; antioxidant action; quantitative analysis; iodometric titration; statistic study

RIS
TY - JOUR
T1 - Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets
A1 - Georgescu, Costinela Valerica
A2 - Gavat, Cristian Catalin
A3 - Voinescu, Doina Carina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 10
SP - 3555
EP - 3560
UR - https://doi.org/10.37358/RC.19.10.7595
KW - ascorbic acid
KW - antioxidant action
KW - quantitative analysis
KW - iodometric titration
KW - statistic study
ER -

BibTex
@article{RevCh2019P3555,
author = {Georgescu Costinela Valerica and Gavat Cristian Catalin and Voinescu Doina Carina},
title = {Iodometric Quantitative Analysis Method of Ascorbic Acid in Tablets},
journal = {Revista de Chimie},
volume = {70},
number = {10},
pages = {3555-3560},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.10.7595},
url = {https://revistadechimie.ro/Articles.asp?ID=7595}
}

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