Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors

Oniga, Smaranda; Araniciu, Catalin; Marc, Gabriel; Uncu, Livia; Palage, Mariana; Oniga, Ovidiu

Smaranda Oniga, Catalin Araniciu, Gabriel Marc, Livia Uncu, Mariana Palage, Ovidiu Oniga

Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors

Abstract:

Considering the well-established antifungal activity of azole compounds, a new series of thiazolyl-methylen-1,3,4-oxadiazolines derivatives were designed and synthesized as lanosterol-demethylase inhibitors. The final compounds were screened for antifungal activity against the Candida albicans ATCC 90028 strain. Molecular docking studies were performed to investigate the interaction modes between the compounds and the active site of lanosterol 14a-demethylase, which is a target enzyme for anticandidal azoles. Theoretical ADME predictions were also calculated for the final compounds 5a-h.

Keywords:
Thiazolyl-methylen-1;3;4-oxadiazolines; Candida albicans; lanosterol 14a-demethylase

Issue: 2019, Volume 70, Issue 10

Pages: 3522-3526

Publication date: 2019/11/15

https://doi.org/10.37358/RC.19.10.7589

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ONIGA, S., ARANICIU, C., MARC, G., UNCU, L., PALAGE, M., ONIGA, O., Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors, Rev. Chim., 70(10), 2019, 3522-3526.

Vancouver
Oniga S, Araniciu C, Marc G, Uncu L, Palage M, Oniga O. Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors. Rev. Chim.[internet]. 2019 Oct;70(10):3522-3526. Available from: https://doi.org/10.37358/RC.19.10.7589

APA 6th edition
Oniga, S., Araniciu, C., Marc, G., Uncu, L., Palage, M. & Oniga, O. (2019). Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors. Revista de Chimie, 70(10), 3522-3526. https://doi.org/10.37358/RC.19.10.7589

Harvard
Oniga, S., Araniciu, C., Marc, G., Uncu, L., Palage, M., Oniga, O. (2019). 'Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors', Revista de Chimie, 70(10), pp. 3522-3526. https://doi.org/10.37358/RC.19.10.7589

IEEE
S. Oniga, C. Araniciu, G. Marc, L. Uncu, M. Palage, O. Oniga, "Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors". Revista de Chimie, vol. 70, no. 10, pp. 3522-3526, 2019. [online]. https://doi.org/10.37358/RC.19.10.7589

Text
Smaranda Oniga, Catalin Araniciu, Gabriel Marc, Livia Uncu, Mariana Palage, Ovidiu Oniga,
Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors,
Revista de Chimie,
Volume 70, Issue 10,
2019,
Pages 3522-3526,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.10.7589.
(https://revistadechimie.ro/Articles.asp?ID=7589)
Keywords: Thiazolyl-methylen-1;3;4-oxadiazolines; Candida albicans; lanosterol 14a-demethylase

RIS
TY - JOUR
T1 - Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors
A1 - Oniga, Smaranda
A2 - Araniciu, Catalin
A3 - Marc, Gabriel
A4 - Uncu, Livia
A5 - Palage, Mariana
A6 - Oniga, Ovidiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 10
SP - 3522
EP - 3526
UR - https://doi.org/10.37358/RC.19.10.7589
KW - Thiazolyl-methylen-1
KW - 3
KW - 4-oxadiazolines
KW - Candida albicans
KW - lanosterol 14a-demethylase
ER -

BibTex
@article{RevCh2019P3522,
author = {Oniga Smaranda and Araniciu Catalin and Marc Gabriel and Uncu Livia and Palage Mariana and Oniga Ovidiu},
title = {Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors},
journal = {Revista de Chimie},
volume = {70},
number = {10},
pages = {3522-3526},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.10.7589},
url = {https://revistadechimie.ro/Articles.asp?ID=7589}
}

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