Resistance and Virulence Features in Carbapenem-resistant Acinetobacter baumannii Community Acquired and Nosocomial Isolates in Romania

Gheorghe, Irina; Cristea, Violeta Corina; Marutescu, Luminita; Popa, Marcela; Murariu, Carmen; Trusca, Bianca Simona; Borcan, Elvira; Ghita, Mihaiela Camelia; Lazar, Veronica; Chifiriuc, Mariana Carmen

Irina Gheorghe, Violeta Corina Cristea, Luminita Marutescu, Marcela Popa, Carmen Murariu, Bianca Simona Trusca, Elvira Borcan, Mihaiela Camelia Ghita, Veronica Lazar, Mariana Carmen Chifiriuc

Resistance and Virulence Features in Carbapenem-resistant Acinetobacter baumannii Community Acquired and Nosocomial Isolates in Romania

Abstract:

We aimed to identify the virulence and antimicrobial resistance features in Carbapenem Resistant Acinetobacter baumannii (CRAB) strains isolated from hospital settings and compare them with those isolated in the same period of time from community acquired (CA) infections in Bucharest, south of Romania. A total number of 93 A. baumannii strains were isolated in majority from hospitalized patients and from CA infections. The resistance and virulence mechanisms of the strains were characterized by phenotypic and genotypic methods. The antibiotic resistance profiles in H and CA A. baumannii isolates revealed high percentages of carbapenem-resistance in both H and CA isolates. The ciprofloxacin resistance was found very closed in both types of isolates (84%/83.33%). CRAB H and CA isolates revealed the intrinsec carbapenemase OXA-51and the acquired carbapenemases OXA-23, OXA-24, IMP,and VIM-2. The blaOXA-23 gene was identified in different plasmid types (GR2-Aci1, GR6-pACICU2). rep135040, p3S18 and Aci6 in H A. baumannii isolates. The most frequently expressed virulence factor was lipase and DN-ase. OXA-51-like alleles corresponding to the two main sequence groups were identified as blaOXA66 (63.63% of the isolates) and respectively, blaOXA-69 (38.39%) and revealed the corresponding type of ompAand csuE sequence grouping. AphA6 (24%/16.6%), AphA1 (16%/16.6%) and aadB (9.3%/5.5%) genes were responsible for aminoglycosides resistance. Our survey revealed a high drug resistance in A. baumannii isolates. Different plasmid groups containing CRAB isolates may facilitate the blaOXA23 dissemination.

Keywords:
carbapenem resistance; virulence; community acquired; nosocomial infections

Issue: 2019, Volume 70, Issue 10

Pages: 3502-3507

Publication date: 2019/11/15

https://doi.org/10.37358/RC.19.10.7584

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GHEORGHE, I., CRISTEA, V.C., MARUTESCU, L., POPA, M., MURARIU, C., TRUSCA, B.S., BORCAN, E., GHITA, M.C., LAZAR, V., CHIFIRIUC, M.C., Resistance and Virulence Features in Carbapenem-resistant Acinetobacter baumannii Community Acquired and Nosocomial Isolates in Romania, Rev. Chim., 70(10), 2019, 3502-3507.

Vancouver
Gheorghe I, Cristea VC, Marutescu L, Popa M, Murariu C, Trusca BS, Borcan E, Ghita MC, Lazar V, Chifiriuc MC. Resistance and Virulence Features in Carbapenem-resistant Acinetobacter baumannii Community Acquired and Nosocomial Isolates in Romania. Rev. Chim.[internet]. 2019 Oct;70(10):3502-3507. Available from: https://doi.org/10.37358/RC.19.10.7584

APA 6th edition
Gheorghe, I., Cristea, V.C., Marutescu, L., Popa, M., Murariu, C., Trusca, B.S.,... Chifiriuc, M.C. (2019). Resistance and Virulence Features in Carbapenem-resistant Acinetobacter baumannii Community Acquired and Nosocomial Isolates in Romania. Revista de Chimie, 70(10), 3502-3507. https://doi.org/10.37358/RC.19.10.7584

Harvard
Gheorghe, I., Cristea, V.C., Marutescu, L., Popa, M., Murariu, C., Trusca, B.S., Borcan, E., Ghita, M.C., Lazar, V., Chifiriuc, M.C. (2019). 'Resistance and Virulence Features in Carbapenem-resistant Acinetobacter baumannii Community Acquired and Nosocomial Isolates in Romania', Revista de Chimie, 70(10), pp. 3502-3507. https://doi.org/10.37358/RC.19.10.7584

IEEE
I. Gheorghe, V.C. Cristea, L. Marutescu, M. Popa, C. Murariu, B.S. Trusca, E. Borcan, M.C. Ghita, V. Lazar, M.C. Chifiriuc, "Resistance and Virulence Features in Carbapenem-resistant Acinetobacter baumannii Community Acquired and Nosocomial Isolates in Romania". Revista de Chimie, vol. 70, no. 10, pp. 3502-3507, 2019. [online]. https://doi.org/10.37358/RC.19.10.7584

Text
Irina Gheorghe, Violeta Corina Cristea, Luminita Marutescu, Marcela Popa, Carmen Murariu, Bianca Simona Trusca, Elvira Borcan, Mihaiela Camelia Ghita, Veronica Lazar, Mariana Carmen Chifiriuc,
Resistance and Virulence Features in Carbapenem-resistant Acinetobacter baumannii Community Acquired and Nosocomial Isolates in Romania,
Revista de Chimie,
Volume 70, Issue 10,
2019,
Pages 3502-3507,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.10.7584.
(https://revistadechimie.ro/Articles.asp?ID=7584)
Keywords: carbapenem resistance; virulence; community acquired; nosocomial infections

RIS
TY - JOUR
T1 - Resistance and Virulence Features in Carbapenem-resistant Acinetobacter baumannii Community Acquired and Nosocomial Isolates in Romania
A1 - Gheorghe, Irina
A2 - Cristea, Violeta Corina
A3 - Marutescu, Luminita
A4 - Popa, Marcela
A5 - Murariu, Carmen
A6 - Trusca, Bianca Simona
A7 - Borcan, Elvira
A8 - Ghita, Mihaiela Camelia
A9 - Lazar, Veronica
A10 - Chifiriuc, Mariana Carmen
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 10
SP - 3502
EP - 3507
UR - https://doi.org/10.37358/RC.19.10.7584
KW - carbapenem resistance
KW - virulence
KW - community acquired
KW - nosocomial infections
ER -

BibTex
@article{RevCh2019P3502,
author = {Gheorghe Irina and Cristea Violeta Corina and Marutescu Luminita and Popa Marcela and Murariu Carmen and Trusca Bianca Simona and Borcan Elvira and Ghita Mihaiela Camelia and Lazar Veronica and Chifiriuc Mariana Carmen},
title = {Resistance and Virulence Features in Carbapenem-resistant Acinetobacter baumannii Community Acquired and Nosocomial Isolates in Romania},
journal = {Revista de Chimie},
volume = {70},
number = {10},
pages = {3502-3507},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.10.7584},
url = {https://revistadechimie.ro/Articles.asp?ID=7584}
}

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