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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 10, 3486-3489

https://doi.org/10.37358/RC.19.10.7581

Amelia Maria Gaman, Cornel Moisa, Camelia Cristina Diaconu, Mihnea Alexandru Gaman

Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential Thrombocythemia

Abstract:

Essential thrombocythemia (ET) is a Philadelphia-negative chronic myeloproliferative neoplasm characterized by acquired somatic mutations: JAK2, CALR or MPL. It is associated with low-grade chronic inflammation, oxidative stress, overproduction of reactive oxygen species (ROS) and antioxidant deficiency. In ET, chronic inflammation and oxidative stress contribute to the genomic instability, the clonal evolution to myelofibrosis and the leukemic transformation. We evaluated ROS levels and the total antioxidant capacity (TAC) in 62 ET patients and investigated the relationship between ROS, TAC, chronic inflammation, leukocytosis, JAK2V617F mutation, and disease progression to myelofibrosis or leukemic transformation. We observed increased levels of ROS and inflammation markers and a decreased TAC in ET patients vs. controls. The acute myeloid leukaemia transformation associated increased levels of oxidative stress and inflammation markers and increased leukocyte counts, while myelofibrosis progression associated an increase in ROS and serum ferritin.
Keywords:
essential thrombocythemia; reactive oxygen species; inflammation; JAK2V617F

Issue: 2019, Volume 70, Issue 10
Pages: 3486-3489
Publication date: 2019/11/15
https://doi.org/10.37358/RC.19.10.7581
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
GAMAN, A.M., MOISA, C., DIACONU, C.C., GAMAN, M.A., Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential Thrombocythemia, Rev. Chim., 70(10), 2019, 3486-3489.

Vancouver
Gaman AM, Moisa C, Diaconu CC, Gaman MA. Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential Thrombocythemia. Rev. Chim.[internet]. 2019 Oct;70(10):3486-3489. Available from: https://doi.org/10.37358/RC.19.10.7581


APA 6th edition
Gaman, A.M., Moisa, C., Diaconu, C.C. & Gaman, M.A. (2019). Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential Thrombocythemia. Revista de Chimie, 70(10), 3486-3489. https://doi.org/10.37358/RC.19.10.7581


Harvard
Gaman, A.M., Moisa, C., Diaconu, C.C., Gaman, M.A. (2019). 'Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential Thrombocythemia', Revista de Chimie, 70(10), pp. 3486-3489. https://doi.org/10.37358/RC.19.10.7581


IEEE
A.M. Gaman, C. Moisa, C.C. Diaconu, M.A. Gaman, "Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential Thrombocythemia". Revista de Chimie, vol. 70, no. 10, pp. 3486-3489, 2019. [online]. https://doi.org/10.37358/RC.19.10.7581


Text
Amelia Maria Gaman, Cornel Moisa, Camelia Cristina Diaconu, Mihnea Alexandru Gaman,
Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential Thrombocythemia,
Revista de Chimie,
Volume 70, Issue 10,
2019,
Pages 3486-3489,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.10.7581.
(https://revistadechimie.ro/Articles.asp?ID=7581)
Keywords: essential thrombocythemia; reactive oxygen species; inflammation; JAK2V617F


RIS
TY - JOUR
T1 - Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential Thrombocythemia
A1 - Gaman, Amelia Maria
A2 - Moisa, Cornel
A3 - Diaconu, Camelia Cristina
A4 - Gaman, Mihnea Alexandru
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 10
SP - 3486
EP - 3489
UR - https://doi.org/10.37358/RC.19.10.7581
KW - essential thrombocythemia
KW - reactive oxygen species
KW - inflammation
KW - JAK2V617F
ER -


BibTex
@article{RevCh2019P3486,
author = {Gaman Amelia Maria and Moisa Cornel and Diaconu Camelia Cristina and Gaman Mihnea Alexandru},
title = {Crosstalk between Oxidative Stress, Chronic Inflammation and Disease Progression in Essential Thrombocythemia},
journal = {Revista de Chimie},
volume = {70},
number = {10},
pages = {3486-3489},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.10.7581},
url = {https://revistadechimie.ro/Articles.asp?ID=7581}
}
 
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