Role of the Biomimetic Scaffolds in the Regeneration of Articular Tissue in Deep Osteochondral Defects in a Rabbit Model

Fodor, Pal; Solyon, Arpad; Fodor, Raluca; Catoi, Cornel; Tabaran, Flaviu; Lacatus, Radu; Trambitas, Cristian; Bataga, Tiberiu

Pal Fodor, Arpad Solyon, Raluca Fodor, Cornel Catoi, Flaviu Tabaran, Radu Lacatus, Cristian Trambitas, Tiberiu Bataga

Role of the Biomimetic Scaffolds in the Regeneration of Articular Tissue in Deep Osteochondral Defects in a Rabbit Model

Abstract:

The ability of damaged articular cartilage to recover with normal hyaline cartilage is limited. Our aim was to study the mechanism of in vivo cartilage repair in case of severe osteochondral lesions using a three-dimensional matrix implanted without any preseeded cells in the osteochondral defect in a rabbit model. According to the ICRS scores from macroscopic observations of the femoral condyles, the average scores in the scaffold groups were higher than those in the control groups at every time (P[0.001). Histological examination of the ostheochondral defects, revealed regeneration of new tissue with hyaline-like cartilage features only in matrix groups. At twelve weeks from implantation, complete filling of the defect with hyaline cartilage with a tendency of mineralization and the absence of implant material is observed. The superficial area of the defect is completely covered with hyaline-like cartilage. The scaffold used leaded to the regeneration of articular tissue with an ordered histoarchitecture.

Keywords:
osteochondral defect; scaffold; hyaline cartilage; mineralization

Issue: 2018, Volume 69, Issue 1

Pages: 201-207

Publication date: 2018/2/15

https://doi.org/10.37358/RC.18.1.6074

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
FODOR, P., SOLYON, A., FODOR, R., CATOI, C., TABARAN, F., LACATUS, R., TRAMBITAS, C., BATAGA, T., Role of the Biomimetic Scaffolds in the Regeneration of Articular Tissue in Deep Osteochondral Defects in a Rabbit Model, Rev. Chim., 69(1), 2018, 201-207.

Vancouver
Fodor P, Solyon A, Fodor R, Catoi C, Tabaran F, Lacatus R, Trambitas C, Bataga T. Role of the Biomimetic Scaffolds in the Regeneration of Articular Tissue in Deep Osteochondral Defects in a Rabbit Model. Rev. Chim.[internet]. 2018 Jan;69(1):201-207. Available from: https://doi.org/10.37358/RC.18.1.6074

APA 6th edition
Fodor, P., Solyon, A., Fodor, R., Catoi, C., Tabaran, F., Lacatus, R., Trambitas, C. & Bataga, T. (2018). Role of the Biomimetic Scaffolds in the Regeneration of Articular Tissue in Deep Osteochondral Defects in a Rabbit Model. Revista de Chimie, 69(1), 201-207. https://doi.org/10.37358/RC.18.1.6074

Harvard
Fodor, P., Solyon, A., Fodor, R., Catoi, C., Tabaran, F., Lacatus, R., Trambitas, C., Bataga, T. (2018). 'Role of the Biomimetic Scaffolds in the Regeneration of Articular Tissue in Deep Osteochondral Defects in a Rabbit Model', Revista de Chimie, 69(1), pp. 201-207. https://doi.org/10.37358/RC.18.1.6074

IEEE
P. Fodor, A. Solyon, R. Fodor, C. Catoi, F. Tabaran, R. Lacatus, C. Trambitas, T. Bataga, "Role of the Biomimetic Scaffolds in the Regeneration of Articular Tissue in Deep Osteochondral Defects in a Rabbit Model". Revista de Chimie, vol. 69, no. 1, pp. 201-207, 2018. [online]. https://doi.org/10.37358/RC.18.1.6074

Text
Pal Fodor, Arpad Solyon, Raluca Fodor, Cornel Catoi, Flaviu Tabaran, Radu Lacatus, Cristian Trambitas, Tiberiu Bataga,
Role of the Biomimetic Scaffolds in the Regeneration of Articular Tissue in Deep Osteochondral Defects in a Rabbit Model,
Revista de Chimie,
Volume 69, Issue 1,
2018,
Pages 201-207,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.1.6074.
(https://revistadechimie.ro/Articles.asp?ID=6074)
Keywords: osteochondral defect; scaffold; hyaline cartilage; mineralization

RIS
TY - JOUR
T1 - Role of the Biomimetic Scaffolds in the Regeneration of Articular Tissue in Deep Osteochondral Defects in a Rabbit Model
A1 - Fodor, Pal
A2 - Solyon, Arpad
A3 - Fodor, Raluca
A4 - Catoi, Cornel
A5 - Tabaran, Flaviu
A6 - Lacatus, Radu
A7 - Trambitas, Cristian
A8 - Bataga, Tiberiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 1
SP - 201
EP - 207
UR - https://doi.org/10.37358/RC.18.1.6074
KW - osteochondral defect
KW - scaffold
KW - hyaline cartilage
KW - mineralization
ER -

BibTex
@article{RevCh2018P201,
author = {Fodor Pal and Solyon Arpad and Fodor Raluca and Catoi Cornel and Tabaran Flaviu and Lacatus Radu and Trambitas Cristian and Bataga Tiberiu},
title = {Role of the Biomimetic Scaffolds in the Regeneration of Articular Tissue in Deep Osteochondral Defects in a Rabbit Model},
journal = {Revista de Chimie},
volume = {69},
number = {1},
pages = {201-207},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.1.6074},
url = {https://revistadechimie.ro/Articles.asp?ID=6074}
}

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